Imperial College London
Portrait Picture

Professor James Seddon

Faculty of Medicine, Department of Infectious Disease

Professor of Global Child Health
 
 
 
//

Contact

 

+44 (0)20 7594 3179james.seddon

 
 
//

Location

 

235Norfolk PlaceSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{van:2022:10.2196/40009,
author = {van, wyk S and Nliwasa, M and Seddon, J and Hoddinott, G and Nepolo, E and Gunther, G and Lin, H and Niemann, S and Gandhi, N and Shah, S and Claassens, M},
doi = {10.2196/40009},
journal = {JMIR Research Protocols},
pages = {1--7},
title = {Drug-resistant tuberculosis case-finding strategies: a scoping review protocol},
url = {http://dx.doi.org/10.2196/40009},
volume = {11},
year = {2022}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background:Transmission of drug-resistant tuberculosis (DR-TB) is ongoing. Finding individuals with DR-TB and initiating treatment as early as possible is important to improve patient clinical outcomes and to break the chain of transmission to control the pandemic. To our knowledge systematic reviews assessing effectiveness, cost-effectiveness, acceptability, and feasibility of different case-finding strategies for DR-TB to inform research, policy, and practice have not been conducted, and it is unknown whether enough research exists to conduct such reviews. It is unknown whether case-finding strategies are similar for DR-TB and drug-susceptible TB and whether we can draw on findings from drug-susceptible reviews to inform decisions on case-finding strategies for DR-TB.Objective:This protocol aims to describe the available literature on case-finding for DR-TB and to describe case-finding strategies.Methods:We will screen systematic reviews, trials, qualitative studies, diagnostic test accuracy studies, and other primary research that specifically sought to improve DR-TB case detection. We will exclude studies that invited individuals seeking care for TB symptoms, those including individuals already diagnosed with TB, or laboratory-based studies. We will search the academic databases including MEDLINE, Embase, The Cochrane Library, Africa-Wide Information, CINAHL, Epistemonikos, and PROSPERO with no language or date restrictions. We will screen titles, abstracts, and full-text articles in duplicate. Data extraction and analyses will be performed using Excel (Microsoft Corp).Results:We will provide a narrative report with supporting figures or tables to summarize the data. A systems-based logic model, developed from a synthesis of case-finding strategies for drug-susceptible TB, will be used as a framework to describe different strategies, resulting pathways, and enhancements of pathways. The search will be conducted at the end of 2021. Title and abstract screening, f
AU  - van,wyk S
AU  - Nliwasa,M
AU  - Seddon,J
AU  - Hoddinott,G
AU  - Nepolo,E
AU  - Gunther,G
AU  - Lin,H
AU  - Niemann,S
AU  - Gandhi,N
AU  - Shah,S
AU  - Claassens,M
DO  - 10.2196/40009
EP  - 7
PY  - 2022///
SN  - 1929-0748
SP  - 1
TI  - Drug-resistant tuberculosis case-finding strategies: a scoping review protocol
T2  - JMIR Research Protocols
UR  - http://dx.doi.org/10.2196/40009
UR  - https://www.researchprotocols.org/2022/12/e40009
UR  - http://hdl.handle.net/10044/1/101196
VL  - 11
ER  -
Download