Publications
169 results found
Cai X, Heng J, 2014, Particle Science and Engineering, Publisher: Royal Society of Chemistry, ISBN: 9781849739573
Discussing the state of the art research in particle science and technology and their roles in the environment, this book will contain a selection of high quality papers from the UK-China International Particle Technology Forum IV held in ...
Lee K-Y, Blaker JJ, Murakami R, et al., 2014, Phase Behavior of Medium and High Internal Phase Water-in-Oil Emulsions Stabilized Solely by Hydrophobized Bacterial Cellulose Nanofibrils, LANGMUIR, Vol: 30, Pages: 452-460, ISSN: 0743-7463
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- Citations: 91
Parambil JV, Poornachary SK, Tan RBH, et al., 2014, Template-induced polymorphic selectivity: the effects of surface chemistry and solute concentration on carbamazepine crystallisation, Crystengcomm, Vol: 16, Pages: 4927-4930, ISSN: 1466-8033
Cooling crystallisation of carbamazepine solution in glass vials functionalised with different silane molecules resulted in preferential nucleation of metastable form II or stable form III polymorphs within a definite range of supersaturation. In contrast, the two crystal forms nucleated concomitantly on a control substrate under similar solution conditions.
Hedberg S, Quigley A, Heng JYY, et al., 2014, Self-interaction chromatography (SIC) of mabs: New methods for estimating the dead volume in SIC and using sic to predict mab stability, Pages: 897-907
Protein-protein molecular interactions are known to be involved in protein solution aggregation behaviour; however the mechanisms leading to protein aggregation are still not fully understood. The osmotic second virial coefficient (B22) is a fundamental physiochemical property that describes proteinprotein interactions in solution, which can be a useful tool to predict aggregation propensity of proteins. This work includes two experimental SIC studies on both model proteins and therapeutic mAbs of different sizes. The first study is an evaluation of two different experimental techniques used to determine SIC dead volumes and the second study uses SIC results for mAb to predict stability. Accurate dead retention volumes are essential for the accurate determinations of B22. The traditional method of estimating dead volume for SIC includes the use of a dead column (without protein immobilised) where the retention volume for proteins can be established. For this technique the dead volume was established for the proteins over a wide range of solution conditions (pH and salt concentrations), and then compared with a new method, where a number of non-interacting dextrans of different molecular weights (MW) (including the MW's of the protein) were employed to find the dead retention volume. The results for the traditional technique with a dead column changed depending on the protein used; only certain model proteins kept a constant dead retention volume when the pH was changing under a constant high salt concentration to minimise protein-surface interactions. Several proteins, including the mAb, exhibited an increased dead retention volume especially when exposed to lower pH. From this it can be concluded that there is no absolute dead volume that can be determined by this technique which are independent of solution conditions. The new technique involving dextrans gives a better overall result for the dead volume for proteins such as mAbs. The second study shows that the SI
Quigley A, Heng JYY, Liddell JM, et al., 2013, The accurate measurement of second virial coefficients using self-interaction chromatography: Experimental considerations, EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, Vol: 85, Pages: 1103-1111, ISSN: 0939-6411
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- Citations: 11
Ali SSM, Heng JYY, Nikolaev AA, et al., 2013, Introducing inverse gas chromatography as a method of determining the surface heterogeneity of minerals for flotation, POWDER TECHNOLOGY, Vol: 249, Pages: 373-377, ISSN: 0032-5910
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- Citations: 38
Kwek JW, Heng D, Lee SH, et al., 2013, High speed imaging with electrostatic charge monitoring to track powder deagglomeration upon impact, JOURNAL OF AEROSOL SCIENCE, Vol: 65, Pages: 77-87, ISSN: 0021-8502
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- Citations: 12
Al-Hashmi AR, Luckham PF, Heng JYY, et al., 2013, Adsorption of High-Molecular-Weight EOR Polymers on Glass Surfaces Using AFM and QCM-D, ENERGY & FUELS, Vol: 27, Pages: 2437-2444, ISSN: 0887-0624
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- Citations: 19
Poornachary SK, Parambil JV, Chow PS, et al., 2013, Nucleation of Elusive Crystal Polymorphs at the Solution-Substrate Contact Line, CRYSTAL GROWTH & DESIGN, Vol: 13, Pages: 1180-1186, ISSN: 1528-7483
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- Citations: 29
Delmas T, Shah UV, Roberts MM, et al., 2013, Crystallisation of the orthorhombic form of acetaminophen: Combined effect of surface topography and chemistry, POWDER TECHNOLOGY, Vol: 236, Pages: 24-29, ISSN: 0032-5910
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- Citations: 16
Khoo JY, Shah UV, Schaepertoens M, et al., 2013, Process-induced phase transformation of carbamazepine dihydrate to its polymorphic anhydrates, POWDER TECHNOLOGY, Vol: 236, Pages: 114-121, ISSN: 0032-5910
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- Citations: 21
Wang GD, Heng JYY, Williams DR, 2013, Dilatometry of powder compacts - Characterizing amorphous-crystalline transformations, POWDER TECHNOLOGY, Vol: 236, Pages: 12-16, ISSN: 0032-5910
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- Citations: 4
Ho R, Heng JYY, 2013, A Review of Inverse Gas Chromatography and its Development as a Tool to Characterize Anisotropic Surface Properties of Pharmaceutical Solids, KONA POWDER AND PARTICLE JOURNAL, Pages: 164-180, ISSN: 0288-4534
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- Citations: 78
Kwek JW, Heng D, Lee SH, et al., 2013, Visualizing Powder De-agglomeration upon Impact with Simultaneous Flowing Charge Behaviour, POWDERS AND GRAINS 2013, Vol: 1542, Pages: 1003-1006, ISSN: 0094-243X
Kwek JW, Jeyabalasingam M, Ng WK, et al., 2012, Comparative Study of the Triboelectric Charging Behavior of Powders Using a Nonintrusive Approach, INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, Vol: 51, Pages: 16488-16494, ISSN: 0888-5885
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- Citations: 10
Burnett DJ, Khoo J, Naderi M, et al., 2012, Effect of Processing Route on the Surface Properties of Amorphous Indomethacin Measured by Inverse Gas Chromatography, AAPS PHARMSCITECH, Vol: 13, Pages: 1511-1517, ISSN: 1530-9932
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- Citations: 18
Ho R, Naderi M, Heng JYY, et al., 2012, Effect of Milling on Particle Shape and Surface Energy Heterogeneity of Needle-Shaped Crystals, PHARMACEUTICAL RESEARCH, Vol: 29, Pages: 2806-2816, ISSN: 0724-8741
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- Citations: 88
Tsekova DS, Williams DR, Heng JYY, 2012, Effect of surface chemistry of novel templates on crystallization of proteins, CHEMICAL ENGINEERING SCIENCE, Vol: 77, Pages: 201-206, ISSN: 0009-2509
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- Citations: 29
Shah UV, Allenby MC, Williams DR, et al., 2012, Crystallization of Proteins at Ultralow Supersaturations Using Novel Three-Dimensional Nanotemplates, CRYSTAL GROWTH & DESIGN, Vol: 12, Pages: 1772-1777, ISSN: 1528-7483
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- Citations: 31
Shah UV, Williams DR, Heng JYY, 2012, Selective Crystallization of Proteins Using Engineered Nanonucleants, CRYSTAL GROWTH & DESIGN, Vol: 12, Pages: 1362-1369, ISSN: 1528-7483
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- Citations: 48
Wang GD, Mallet FP, Ricard F, et al., 2012, Pharmaceutical nanocrystals, Current Opinion in Chemical Engineering, Vol: 1, Pages: 102-107
Parambil JV, Schaepertoens M, Williams DR, et al., 2011, Effects of Oscillatory Flow on the Nucleation and Crystallization of Insulin, CRYSTAL GROWTH & DESIGN, Vol: 11, Pages: 4353-4359, ISSN: 1528-7483
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- Citations: 38
Ho R, Dilworth SE, Williams DR, et al., 2011, Role of Surface Chemistry and Energetics in High Shear Wet Granulation, INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, Vol: 50, Pages: 9642-9649, ISSN: 0888-5885
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- Citations: 31
Kwek JW, Vakarelski IU, Ng WK, et al., 2011, Novel parallel plate condenser for single particle electrostatic force measurements in atomic force microscope, COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, Vol: 385, Pages: 206-212, ISSN: 0927-7757
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- Citations: 14
Burnett DJ, Heng JYY, Thielmann F, et al., 2011, Measuring Surface Roughness of Pharmaceutical Powders Using Vapor Sorption Methods, AAPS PHARMSCITECH, Vol: 12, Pages: 56-61, ISSN: 1530-9932
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- Citations: 9
Heng JYY, Williams DR, 2011, Vapour Sorption and Surface Analysis, Solid State Characterization of Pharmaceuticals, Editors: Storey, Ymén, Publisher: Wiley-Blackwell, ISBN: 9780470659359
This book provides an up-to-date review of the current techniques used to characterize pharmaceutical solids.
Jefferson AE, Williams DR, Heng JYY, 2011, Computing the Surface Energy Distributions of Heterogeneous Crystalline Powders, JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY, Vol: 25, Pages: 339-355, ISSN: 0169-4243
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- Citations: 24
Delmas T, Roberts MM, Heng JYY, 2011, Nucleation and Crystallization of Lysozyme: Role of Substrate Surface Chemistry and Topography, JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY, Vol: 25, Pages: 357-366, ISSN: 0169-4243
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- Citations: 20
Seevaratnam GK, Ding H, Michel O, et al., 2010, Laminar flow deformation of a droplet adhering to a wall in a channel, CHEMICAL ENGINEERING SCIENCE, Vol: 65, Pages: 4523-4534, ISSN: 0009-2509
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- Citations: 32
Rasool N, Yasin T, Heng JYY, et al., 2010, Synthesis and characterization of novel pH-, ionic strength and temperature- sensitive hydrogel for insulin delivery, POLYMER, Vol: 51, Pages: 1687-1693, ISSN: 0032-3861
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- Citations: 124
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