Imperial College London
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Professor Jerry Heng

Faculty of Engineering, Department of Chemical Engineering

Professor in Particle Technology
 
 
 
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Contact

 

+44 (0)20 7594 0784jerry.heng

 
 
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Location

 

208ACE ExtensionSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ouyang:2021:10.1039/d0ce01357a,
author = {Ouyang, J and Chen, J and Rosbottom, I and Chen, W and Guo, M and Heng, JYY},
doi = {10.1039/d0ce01357a},
journal = {CrystEngComm},
pages = {813--823},
title = {Supersaturation and solvent dependent nucleation of carbamazepine polymorphs during rapid cooling crystallization},
url = {http://dx.doi.org/10.1039/d0ce01357a},
volume = {23},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Polymorphic nucleation behavior of carbamazepine (CBZ) was investigated in terms of supersaturation in several solvents: nitromethane, acetonitrile, acetone, ethanol, 2-propanol and toluene. The solubility was measured and the effects of interaction between the solvent and CBZ on solubility and polymorphic nucleation were discussed. It was found that the polymorphic forms of CBZ largely depended on the solvent type and supersaturation ratio. The carbonyl group in acetone blocked the NHO interaction between the dimer in form II by mimicking the same interaction with CBZ, then favored the nucleation of form III. The aromatic–aromatic interaction between CBZ and the solvent like toluene decreased the solute–solute interaction and favored the formation of form II. The nucleation domains of CBZ polymorphs (forms II and III) were separated as a function of supersaturation ratio range in each solvent, and the effects of solvents and supersaturation ratios on the induction time and transformation process were also explored. The interfacial energies of forms II and III in different solvents were calculated, and it was found that, at all investigated supersaturation ratios, the interfacial energy of form II in all solvents except acetone was always lower than that of form III, indicating that nucleation kinetics preferably favored the formation of form II. However, at lower supersaturation ratios, thermodynamics was critical and form III was obtained.
AU  - Ouyang,J
AU  - Chen,J
AU  - Rosbottom,I
AU  - Chen,W
AU  - Guo,M
AU  - Heng,JYY
DO  - 10.1039/d0ce01357a
EP  - 823
PY  - 2021///
SN  - 1466-8033
SP  - 813
TI  - Supersaturation and solvent dependent nucleation of carbamazepine polymorphs during rapid cooling crystallization
T2  - CrystEngComm
UR  - http://dx.doi.org/10.1039/d0ce01357a
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000613496600007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://pubs.rsc.org/en/content/articlelanding/2021/CE/D0CE01357A#!divAbstract
UR  - http://hdl.handle.net/10044/1/87002
VL  - 23
ER  -
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