Imperial College London
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Professor Jerry Heng

Faculty of Engineering, Department of Chemical Engineering

Professor in Particle Technology
 
 
 
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Contact

 

+44 (0)20 7594 0784jerry.heng

 
 
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Location

 

208ACE ExtensionSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ouyang:2021:10.1021/acs.iecr.0c04906,
author = {Ouyang, J and Chen, J and Chen, W and Rosbottom, I and Guo, M and Heng, JYY},
doi = {10.1021/acs.iecr.0c04906},
journal = {Industrial and Engineering Chemistry Research},
pages = {939--946},
title = {Application of phenyl-functionalized porous silica for the selective crystallization of carbamazepine metastable form II},
url = {http://dx.doi.org/10.1021/acs.iecr.0c04906},
volume = {60},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Polymorphic nucleation of carbamazepine (CBZ) in several solvents (ethanol, 2-propanol, acetone, acetonitrile, toluene, and nitromethane) was investigated with different functionalized porous silica templates. It was found that the introduction of silica templates with different surface chemistries such as −OH, −NH2, and −phenyl affected the polymorphic outcomes. At a low supersaturation ratio, stable form III of CBZ was prone to nucleate as expected. However, the results in this work confirmed that a phenyl-functionalized porous silica template could crystallize and maintain metastable form II of CBZ at a low supersaturation ratio for a long time. In terms of the underlying mechanism, the aromatic–aromatic interaction between the surface of phenyl-functionalized silica and the CBZ molecule played an important role in stabilizing metastable form II. The influence of the amount of silica templates on the polymorph formation was also investigated. Our results will help to crystallize and maintain metastable materials, even at a low supersaturation ratio.
AU  - Ouyang,J
AU  - Chen,J
AU  - Chen,W
AU  - Rosbottom,I
AU  - Guo,M
AU  - Heng,JYY
DO  - 10.1021/acs.iecr.0c04906
EP  - 946
PY  - 2021///
SN  - 0888-5885
SP  - 939
TI  - Application of phenyl-functionalized porous silica for the selective crystallization of carbamazepine metastable form II
T2  - Industrial and Engineering Chemistry Research
UR  - http://dx.doi.org/10.1021/acs.iecr.0c04906
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000612558700012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://pubs.acs.org/doi/10.1021/acs.iecr.0c04906
UR  - http://hdl.handle.net/10044/1/87001
VL  - 60
ER  -
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