Imperial College London


Faculty of MedicineInstitute of Clinical Sciences

Professor of Cell Proliferation



+44 (0)20 3313 8263jesus.gil




CRB room 5005CRB (Clinical Research Building)Hammersmith Campus





Jesús was born in Zaragoza, Spain. He obtained his PhD, on the elucidation of how the dsRNA-dependent protein kinase induces apoptosis and activates NF-kB, in 2000 at the Universidad Autónoma in Madrid.

From 2000 to 2003 he worked with David Beach at the Wolfson Institute for Biomedical Research, University College London, where he screened for genes bypassing senescence, identifying CBX7. In January 2004, he joined Gordon Peters' group at the CRUK London Research Institute, investigating how CBX7 regulates the INK4/ARF locus.

During 2005 he worked in Scott Lowe's laboratory at Cold Spring Harbor, New York, developing models to study CBX7 function in vivo. Since Nov. 2005 he leads the Cell Proliferation Group at the MRC Clinical Sciences Centre, investigating the genetic and epigenetic regulation of the INK4a/ARF locus by PcG complexes and screening for agents controlling senescence. In November 2008, Jesús was named an EMBO Young Investigator.

More information about Jesus Gil's lab can be found at the following sites:



Gil J, PTBP1-mediated alternative splicing regulates the inflammatory secretome and the pro-tumorigenic effects of senescent cells, Cancer Cell, ISSN:1535-6108

Bowling S, Di Gregorio A, Sancho M, et al., 2018, P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development, Nature Communications, Vol:9, ISSN:2041-1723

Apps JR, Carreno G, Mario Gonzalez-Meljem J, et al., 2018, Tumour compartment transcriptomics demonstrates the activation of inflammatory and odontogenic programmes in human adamantinomatous craniopharyngioma and identifies the MAPK/ERK pathway as a novel therapeutic target, Acta Neuropathologica, Vol:135, ISSN:0001-6322, Pages:757-777

Herranz N, Gil J, 2018, Mechanisms and functions of cellular senescence., J Clin Invest, Vol:128, Pages:1238-1246

Wagner V, Gil J, 2018, An Epigenetic Switch: From Senescent Melanocytes to Malignant Melanoma (and Back)., Cancer Cell, Vol:33, Pages:162-163

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