Imperial College London
Alternate

ProfessorJesusGil

Faculty of Medicine, Institute of Clinical Sciences

Professor of Cell Proliferation
 
 
 
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Contact

 

+44 (0)20 3313 8263jesus.gil

 
 
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Location

 

ICTEM room 230ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Martínez-Zamudio:2020:10.1038/s41556-020-0529-5,
author = {Martínez-Zamudio, RI and Roux, P-F and Américo, NLF de Freitas J and Robinson, L and Doré, G and Sun, B and Belenki, D and Milanovic, M and Herbig, U and Schmitt, CA and Gil, J and Bischof, O},
doi = {10.1038/s41556-020-0529-5},
journal = {Nature Cell Biology},
pages = {842--855},
title = {AP-1 imprints a reversible transcriptional program of senescent cells},
url = {http://dx.doi.org/10.1038/s41556-020-0529-5},
volume = {22},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Senescent cells affect many physiological and pathophysiological processes. While select genetic and epigenetic elements for senescence induction have been identified, the dynamics, epigenetic mechanisms and regulatory networks defining senescence competence, induction and maintenance remain poorly understood, precluding the deliberate therapeutic targeting of senescence for health benefits. Here, we examined the possibility that the epigenetic state of enhancers determines senescent cell fate. We explored this by generating time-resolved transcriptomes and epigenome profiles during oncogenic RAS-induced senescence and validating central findings in different cell biology and disease models of senescence. Through integrative analysis and functional validation, we reveal links between enhancer chromatin, transcription factor recruitment and senescence competence. We demonstrate that activator protein 1 (AP-1) ‘pioneers’ the senescence enhancer landscape and defines the organizational principles of the transcription factor network that drives the transcriptional programme of senescent cells. Together, our findings enabled us to manipulate the senescence phenotype with potential therapeutic implications.
AU  - Martínez-Zamudio,RI
AU  - Roux,P-F
AU  - Américo,NLF de Freitas J
AU  - Robinson,L
AU  - Doré,G
AU  - Sun,B
AU  - Belenki,D
AU  - Milanovic,M
AU  - Herbig,U
AU  - Schmitt,CA
AU  - Gil,J
AU  - Bischof,O
DO  - 10.1038/s41556-020-0529-5
EP  - 855
PY  - 2020///
SN  - 1465-7392
SP  - 842
TI  - AP-1 imprints a reversible transcriptional program of senescent cells
T2  - Nature Cell Biology
UR  - http://dx.doi.org/10.1038/s41556-020-0529-5
UR  - https://www.nature.com/articles/s41556-020-0529-5
UR  - http://hdl.handle.net/10044/1/79846
VL  - 22
ER  -
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