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@article{de:2020:10.1038/s41568-020-0267-9,
author = {de, Bono JS and Guo, C and Gurel, B and De, Marzo AM and Sfanos, KS and Mani, RS and Gil, J and Drake, CG and Alimonti, A},
doi = {10.1038/s41568-020-0267-9},
journal = {Nature Reviews Cancer},
pages = {455--469},
title = {Prostate carcinogenesis: inflammatory storms},
url = {http://dx.doi.org/10.1038/s41568-020-0267-9},
volume = {20},
year = {2020}
}

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TY  - JOUR
AB  - Prostate cancer is a major cause of cancer morbidity and mortality. Intra-prostatic inflammation is a risk factor for prostate carcinogenesis, with diet, chemical injury and an altered microbiome being causally implicated. Intra-prostatic inflammatory cell recruitment and expansion can ultimately promote DNA double-strand breaks and androgen receptor activation in prostate epithelial cells. The activation of the senescence-associated secretory phenotype fuels further 'inflammatory storms', with free radicals leading to further DNA damage. This drives the overexpression of DNA repair and tumour suppressor genes, rendering these genes susceptible to mutagenic insults, with carcinogenesis accelerated by germline DNA repair gene defects. We provide updates on recent advances in elucidating prostate carcinogenesis and explore novel therapeutic and prevention strategies harnessing these discoveries.
AU  - de,Bono JS
AU  - Guo,C
AU  - Gurel,B
AU  - De,Marzo AM
AU  - Sfanos,KS
AU  - Mani,RS
AU  - Gil,J
AU  - Drake,CG
AU  - Alimonti,A
DO  - 10.1038/s41568-020-0267-9
EP  - 469
PY  - 2020///
SN  - 1474-175X
SP  - 455
TI  - Prostate carcinogenesis: inflammatory storms
T2  - Nature Reviews Cancer
UR  - http://dx.doi.org/10.1038/s41568-020-0267-9
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32546840
UR  - https://www.nature.com/articles/s41568-020-0267-9
UR  - http://hdl.handle.net/10044/1/80469
VL  - 20
ER  -

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