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@article{Birch:2020:10.1101/gad.343129.120,
author = {Birch, J and Gil, J},
doi = {10.1101/gad.343129.120},
journal = {Genes and Development},
pages = {1565--1576},
title = {Senescence and the SASP: many therapeutic avenues},
url = {http://dx.doi.org/10.1101/gad.343129.120},
volume = {34},
year = {2020}
}

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TY  - JOUR
AB  - Cellular senescence is a stress response that elicits a permanent cell cycle arrest and triggers profound phenotypic changes such as the production of a  bioactive secretome, referred to as the senescence-associated secretory phenotype (SASP). Acute senescence induction protects against cancer and limits fibrosis, but lingering senescent cells drive age-related disorders. Thus, targeting senescent cells to delay ageing and limit dysfunction, known as ‘senotherapy’, is gaining momentum. While drugs that selectively kill senescent cells,  termed  ‘senolytics’,  are a  major focus, SASP-centered approaches are emerging as alternatives to target senescence-associated diseases. Here, we summarise the regulation and functions of the SASP and highlight the therapeutic potential of SASP modulation as complimentary, or an alternative to, current senolytic approaches.
AU  - Birch,J
AU  - Gil,J
DO  - 10.1101/gad.343129.120
EP  - 1576
PY  - 2020///
SN  - 0890-9369
SP  - 1565
TI  - Senescence and the SASP: many therapeutic avenues
T2  - Genes and Development
UR  - http://dx.doi.org/10.1101/gad.343129.120
UR  - http://genesdev.cshlp.org/content/34/23-24/1565
UR  - http://hdl.handle.net/10044/1/84265
VL  - 34
ER  -

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