Imperial College London
Alternate

ProfessorJesusGil

Faculty of Medicine, Institute of Clinical Sciences

Professor of Cell Proliferation
 
 
 
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Contact

 

+44 (0)20 3313 8263jesus.gil

 
 
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Location

 

ICTEM room 230ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{McHugh:2017:10.1083/jcb.201708092,
author = {McHugh, D and Gil, J},
doi = {10.1083/jcb.201708092},
journal = {Journal of Cell Biology},
pages = {65--77},
title = {Senescence and aging – causes, consequences, and therapeutic avenues},
url = {http://dx.doi.org/10.1083/jcb.201708092},
volume = {217},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Aging is the major risk factor for cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. Although we are far from understanding the biological basis of aging, research suggests that targeting the aging process itself could ameliorate many age-related pathologies. Senescence is a cellular response characterized by a stable growth arrest and other phenotypic alterations that include a proinflammatory secretome. Senescence plays roles in normal development, maintains tissue homeostasis, and limits tumor progression. However, senescence has also been implicated as a major cause of age-related disease. In this regard, recent experimental evidence has shown that the genetic or pharmacological ablation of senescent cells extends life span and improves health span. Here, we review the cellular and molecular links between cellular senescence and aging and discuss the novel therapeutic avenues that this connection opens.
AU  - McHugh,D
AU  - Gil,J
DO  - 10.1083/jcb.201708092
EP  - 77
PY  - 2017///
SN  - 0021-9525
SP  - 65
TI  - Senescence and aging – causes, consequences, and therapeutic avenues
T2  - Journal of Cell Biology
UR  - http://dx.doi.org/10.1083/jcb.201708092
UR  - http://hdl.handle.net/10044/1/52021
VL  - 217
ER  -
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