Imperial College London
Alternate

ProfessorJesusGil

Faculty of Medicine, Institute of Clinical Sciences

Professor of Cell Proliferation
 
 
 
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Contact

 

+44 (0)20 3313 8263jesus.gil

 
 
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Location

 

ICTEM room 230ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gonzalez-Meljem:2017:10.1038/s41467-017-01992-5,
author = {Gonzalez-Meljem, JM and Haston, S and Carreno, G and Apps, J and Pozzi, S and Stache, C and Kaushal, G and Virasami, A and Panousopoulos, L and Mousavy-Gharavy, SN and Guerrero, A and Rashid, M and Jani, N and Goding, CR and Jacques, TS and Adams, DJ and Gil, J and Andoniadou, CL and Martinez-Barbera, JP},
doi = {10.1038/s41467-017-01992-5},
journal = {Nature Communications},
title = {Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma},
url = {http://dx.doi.org/10.1038/s41467-017-01992-5},
volume = {8},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Senescent cells may promote tumour progression through the activation of a senescence-associated secretory phenotype (SASP), whether these cells are capable of initiating tumourigenesis in vivo is not known. Expression of oncogenic β-catenin in Sox2+ young adult pituitary stem cells leads to formation of clusters of stem cells and induction of tumours resembling human adamantinomatous craniopharyngioma (ACP), derived from Sox2− cells in a paracrine manner. Here, we uncover the mechanisms underlying this paracrine tumourigenesis. We show that expression of oncogenic β-catenin in Hesx1+ embryonic precursors also results in stem cell clusters and paracrine tumours. We reveal that human and mouse clusters are analogous and share a common signature of senescence and SASP. Finally, we show that mice with reduced senescence and SASP responses exhibit decreased tumour-inducing potential. Together, we provide evidence that senescence and a stem cell-associated SASP drive cell transformation and tumour initiation in vivo in an age-dependent fashion.
AU  - Gonzalez-Meljem,JM
AU  - Haston,S
AU  - Carreno,G
AU  - Apps,J
AU  - Pozzi,S
AU  - Stache,C
AU  - Kaushal,G
AU  - Virasami,A
AU  - Panousopoulos,L
AU  - Mousavy-Gharavy,SN
AU  - Guerrero,A
AU  - Rashid,M
AU  - Jani,N
AU  - Goding,CR
AU  - Jacques,TS
AU  - Adams,DJ
AU  - Gil,J
AU  - Andoniadou,CL
AU  - Martinez-Barbera,JP
DO  - 10.1038/s41467-017-01992-5
PY  - 2017///
SN  - 2041-1723
TI  - Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-017-01992-5
UR  - http://hdl.handle.net/10044/1/52828
VL  - 8
ER  -
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