DrJiaGuo

Faculty of Medicine, Department of Infectious Disease

Research Associate

Contact

Location

Chelsea and Westminster HospitalChelsea and Westminster Campus

Summary

I am a postdoctoral research associate at the new Centre for Immunology and Vaccinology (CIV). I joined the group of Prof. Xiao-Ning Xu in September 2014. My current research work focuses on investigating B cell responses to HIV and HCV co-infection.

Before I come to Imperial College London, I have just completed my PhD study in AIDS Institute at the University of Hong Kong. This research group is at the leading edge in the field of AIDS research, education and prevention in China. During the five years of research there, I have been working on the function of humoral immunity against HIV/SIV infection. In particular, I have contributed significantly to revealing the distinct antigenic determinants targeted by the vaccine-induced antibodies tested in macaque models, which indicated the significant role of specific antibody responses in controlling SIV replication. In addition, I have developed a modified bispecific neutralizing antibodies against HIV-1 infection, which is a novel construct and promising for passive immunization as a PrEP candidate.

Publications

Journals

Rijal P, Elias SC, Machado SR, et al.Rijal P, Elias SC, Machado SR, Xiao J, Schimanski L, O'Dowd V, Baker T, Barry E, Mendelsohn SC, Cherry CJ, Jin J, Labbé GM, Donnellan FR, Rampling T, Dowall S, Rayner E, Findlay-Wilson S, Carroll M, Guo J, Xu XN, Huang KYA, Takada A, Burgess G, McMillan D, Popplewell A, Lightwood DJ, Draper SJ, Townsend AR close, 2019, Therapeutic monoclonal antibodies for Ebola virus infection derived from vaccinated humans, Cell Reports, Vol:27, ISSN:2211-1247, Pages:172-186.e7

Wu X, Guo J, Niu M, et al.Wu X, Guo J, Niu M, An M, Liu L, Wang H, Jin X, Zhang Q, Lam KS, Wu T, Wang H, Wang Q, Du Y, Li J, Cheng L, Tang HY, Shang H, Zhang L, Zhou P, Chen Z close, 2018, Tandem bispecific neutralizing antibody eliminates HIV-1 infection in humanized mice, Journal of Clinical Investigation, Vol:128, ISSN:0021-9738, Pages:2239-2251

Tang X, Guo J, Cheng L, et al.Tang X, Guo J, Cheng L, Sun C, Liu L, Zuo T, Wang H, Chen L, Zhang L, Chen Z close, 2017, Single N277A substitution in C2 of simian immunodeficiency virus envelope influences vaccine-elicited CD4i neutralizing and anti-V2 antibody responses, Vaccine, Vol:35, ISSN:0264-410X, Pages:2582-2591

Cheng L, Tang X, Liu L, et al.Cheng L, Tang X, Liu L, Peng J, Nishiura K, Cheung AKL, Guo J, Wu X, Tang HY, An M, Zhou J, Cheung KW, Wang H, Guan X, Wu Z, Chen Z close, 2015, Monoclonal antibodies specific to human Δ42PD1: A novel immunoregulator potentially involved in HIV-1 and tumor pathogenesis, Mabs, Vol:7, ISSN:1942-0862, Pages:620-629

Conference

McFaul K, Guo J, Atkins E, et al.McFaul K, Guo J, Atkins E, Xu X-N, Kelleher P close, 2016, A novel method to assess the functional of the anti-HIV gp-41 antibody in acute HIV-1 infection, 22nd Annual Conference of the British HIV Association (BHIVA), Wiley, Pages:27-27, ISSN:1464-2662

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