Publications
136 results found
Seyfried F, Li JV, Miras AD, et al., 2013, Urinary phenotyping indicates weight loss independent metabolic effects of Roux-en-Y Gastric Bypass in mice, Journal of Proteome Research
Li JV, Saric J, Yap IKS, et al., 2013, Metabonomic investigations of age- and batch-related variations in female NMRI mice using proton nuclear magnetic resonance spectroscopy, MOLECULAR BIOSYSTEMS, Vol: 9, Pages: 3155-3165, ISSN: 1742-206X
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- Citations: 8
Holmes E, Li JV, Marchesi JR, et al., 2012, Gut Microbiota Composition and Activity in Relation to Host Metabolic Phenotype and Disease Risk, CELL METABOLISM, Vol: 16, Pages: 559-564, ISSN: 1550-4131
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- Citations: 334
Holmes E, Li JV, Marchesi JR, et al., 2012, Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk, Cell Metabolism, Vol: 5, Pages: 559-564
Li JV, Marchesi JR, 2012, Gut microbe-host metabolic interactions in health and disease: Exploring host and gut microbiota connections could uncover the mechanisms of various diseases along with targets for drugs with which to treat them, Microbe, Vol: 7, ISSN: 1558-7452
Complex host-microbial interactions are essential for health and, when disrupted, can give rise to a wide variety of diseases. Microbial functions might help to account for host metabolic disorders such as obesity and diabetes. Bariatric surgery to control obesity may work, in part, by perturbing the gut microbiota, changing metabolic dynamics, and leading to long-term weight loss. Accruing evidence suggests that gut microbes can affect brain development and behavior. © 2009 American Society for Microbiology.
Zhao L, Nicholson JK, Lu A, et al., 2012, Targeting the Human Genome-Microbiome Axis for Drug Discovery: Inspirations from Global Systems Biology and Traditional Chinese Medicine, JOURNAL OF PROTEOME RESEARCH, Vol: 11, Pages: 3509-3519, ISSN: 1535-3893
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- Citations: 49
LI JV, Marchesi JR, 2012, Gut Microbial-Host Metabolic Interactions in Health and Disease
Wu Q, Li JV, Seyfried F, et al., 2012, Bariatric surgery profoundly changes circulating MicroRNA profile in the rat, CANCER RESEARCH, Vol: 72, ISSN: 0008-5472
Marchesi JR, Li J, Holmes E, et al., 2012, Reply, Gastroenterology, Vol: 142, Pages: 401-402, ISSN: 0016-5085
Li JV, Ashrafian H, Bueter M, et al., 2012, Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk, Gut, Vol: 60, Pages: 1214-1223
Alves AC, Li JV, Garcia-Perez I, et al., 2012, Characterization of data analysis methods for information recovery from metabolic 1H NMR spectra using artificial complex mixtures, Metabolomics, Vol: 8, Pages: 1170-1180
Veselkov KA, Vingara LK, Masson P, et al., 2011, Response to Comment on "Optimized Preprocessing of Ultra-Performance Liquid Chromatography/Mass Spectrometry Urinary Metabolic Profiles for Improved Information Recovery", ANALYTICAL CHEMISTRY, Vol: 83, Pages: 9721-9722, ISSN: 0003-2700
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- Citations: 2
Hawkes GE, de Wet H, Li J, 2011, Polar Compounds Isolated from the Leaves of <i>Albertisia delagoensis</i> (Menispermaceae), MOLECULES, Vol: 16, Pages: 9153-9160
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- Citations: 2
Li JV, Saric J, Wang Y, et al., 2011, Chemometric analysis of biofluids from mice experimentally infected with <i>Schistosoma mansoni</i>, PARASITES & VECTORS, Vol: 4, ISSN: 1756-3305
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- Citations: 23
LI JV, Reshat R, Wu Q, et al., 2011, Experimental bariatric surgery in rats generates a cytotoxic chemical environment in the gut contents, Frontiers in Microbiology, Vol: 2, Pages: 1-9
Nicholson G, Rantalainen M, Li JV, et al., 2011, A Genome-Wide Metabolic QTL Analysis in Europeans Implicates Two Loci Shaped by Recent Positive Selection, PLOS GENETICS, Vol: 7, ISSN: 1553-7404
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- Citations: 99
Veselkov KA, Vingara LK, Masson P, et al., 2011, Optimized Preprocessing of Ultra-Performance Liquid Chromatography/Mass Spectrometry Urinary Metabolic Profiles for Improved Information Recovery, ANALYTICAL CHEMISTRY, Vol: 83, Pages: 5864-5872, ISSN: 0003-2700
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- Citations: 211
Ashrafian H, Li JV, Bueter M, et al., 2011, Metabolic Surgery Modulates the Systemic Metabolic Profile and Gut Microbial Ecology, 16th Congress of the International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO), Publisher: SPRINGER, Pages: 1098-1098, ISSN: 0960-8923
Nicholson G, Rantalainen M, Maher AD, et al., 2011, Human metabolic profiles are stably controlled by genetic and environmental variation, MOLECULAR SYSTEMS BIOLOGY, Vol: 7, ISSN: 1744-4292
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- Citations: 120
Ashrafian H, LI JV, Bueter M, et al., 2011, Metabolic Surgery Modulates the Systemic Metabolic Profile and Gut Microbial Ecology, 16th Congress of the International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO)
Holmes E, Li JV, Athanasiou T, et al., 2011, Understanding the role of gut microbiome-host metabolic signal disruption in health and disease, TRENDS IN MICROBIOLOGY, Vol: 19, Pages: 349-359, ISSN: 0966-842X
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- Citations: 369
Holmes E, Li JV, Athanasiou T, et al., 2011, Understanding the role of gut microbiome-host metabolic signal disruption in health and disease, Trends in Microbiology, Pages: 349-359
Li J, 2011, Jia Li, BIOANALYSIS, Vol: 3, Pages: 1077-1078, ISSN: 1757-6180
Li JV, Ashrafian H, 2011, Host-microbial interactions post Roux-en-Y gastric bypass, International Human Microbiome Congress
Li JV, Saric J, Wang Y, et al., 2011, Metabonomic Investigation of Single and Multiple Strain Trypanosoma brucei brucei Infections, American Journal of Tropical Medicine and Hygiene, Vol: 84, Pages: 91-98, ISSN: 1476-1645
Although co-infections are common and can have important epidemiologic and evolutionary consequences, studies exploring biochemical effects of multiple-strain infections remain scarce. We studied metabolic responses of NMRI mice to Trypanosoma brucei brucei single (STIB777AE-Green1 or STIB246BA-Red1) and co-infections using a 1H nuclear magnetic resonance (NMR) spectroscopy-based metabolic profiling strategy. All T. b. brucei infections caused an alteration in urinary biochemical composition by day 4 postinfection, characterized by increased concentrations of 2-oxoisocaproate, D-3-hydroxybutyrate, lactate, 4-hydroxyphenylacetate, phenylpyruvate, and 4-hydroxyphenylpyruvate, and decreased levels of hippurate. Although there were no marked differences in metabolic signatures observed in the mouse infected with a single or dual strain of T. b. brucei, there was a slower metabolic response in mice infected with T. b. brucei green strain compared with mice infected with either the red strain or both strains concurrently. Pyruvate, phenylpyruvate, and hippurate were correlated with parasitemia, which might be useful in monitoring responses to therapeutic interventions.
LI JV, Ashrafian H, Bueter M, et al., 2011, Metabolic Surgery Regulates the Crosstalk between Mammalian Metabolism and the Microbiome, Keystone Symposia: Obesity (J2)
Gavaghan CL, Li JV, Hadfield ST, et al., 2010, Application of NMR-based Metabolomics to the Investigation of Salt Stress in Maize (Zea mays), PHYTOCHEMICAL ANALYSIS, Vol: 22, Pages: 214-224, ISSN: 0958-0344
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- Citations: 78
Ashrafian H, Athanasiou T, JV L, et al., 2010, Diabetes resolution and hyperinsulinaemia after metabolic Roux-en-Y gastric bypass, Obes Rev
Saric J, Li JV, Utzinger J, et al., 2010, Systems parasitology: effects of Fasciola hepatica on the neurochemical profile in the rat brain., Mol Syst Biol, Vol: 6
We characterize the integrated response of a rat host to the liver fluke Fasciola hepatica using a combination of (1)H nuclear magnetic resonance spectroscopic profiles (liver, kidney, intestine, brain, spleen, plasma, urine, feces) and multiplex cytokine markers of systemic inflammation. Multivariate mathematical models were built to describe the main features of the infection at the systems level. In addition to the expected modulation of hepatic choline and energy metabolism, we found significant perturbations of the nucleotide balance in the brain, together with increased plasma IL-13, suggesting a shift toward modulation of immune reactions to minimize inflammatory damage, which may favor the co-existence of the parasite in the host. Subsequent analysis of brain extracts from other trematode infection models (i.e. Schistosoma mansoni, and Echinostoma caproni) did not elicit a change in neural nucleotide levels, indicating that the neural effects of F. hepatica infection are specific. We propose that the topographically extended response to invasion of the host as characterized by the modulated global metabolic phenotype is stratified across several bio-organizational levels and reflects the direct manipulation of host-nucleotide balance.
Saric J, Li JV, Swann JR, et al., 2010, Integrated Cytokine and Metabolic Analysis of Pathological Responses to Parasite Exposure in Rodents, JOURNAL OF PROTEOME RESEARCH, Vol: 9, Pages: 2255-2264, ISSN: 1535-3893
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- Citations: 33
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