Publications
136 results found
Wang Y, Li JV, Saric J, et al., 2010, Advances in metabolic profiling of experimental nematode and trematode infections., Advances in Parasitology, Vol: 73, Pages: 373-404
Saric J, Li JV, Wang Y, et al., 2009, Panorganismal Metabolic Response Modeling of an Experimental <i>Echinostoma caproni</i> Infection in the Mouse, JOURNAL OF PROTEOME RESEARCH, Vol: 8, Pages: 3899-3911, ISSN: 1535-3893
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- Citations: 29
Li JV, Holmes E, Saric J, et al., 2009, Metabolic profiling of a <i>Schistosoma mansoni</i> infection in mouse tissues using magic angle spinning-nuclear magnetic resonance spectroscopy, INTERNATIONAL JOURNAL FOR PARASITOLOGY, Vol: 39, Pages: 547-558, ISSN: 0020-7519
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- Citations: 49
LI JIA, 2009, Metabonomic Characterisation of Host-Parasite Interactions in vivo
Garcia-Perez I, Couto Alves A, Angulo S, et al., 2009, Bidirectional correlation of NMR and capillary electrophoresis fingerprints: a new approach to investigating Schistosoma mansoni infection in a mouse model, Analytical chemistry, Vol: 82, Pages: 203-210
Li J, Saric J, Wang Y, et al., 2008, METABOLIC PROFILING OF CO-INFECTION OF <i>TRYPANOSOMA BRUCEI BRUCEI</i> STRAINS IN MICE, 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene, Publisher: AMER SOC TROP MED & HYGIENE, Pages: 104-104, ISSN: 0002-9637
Saric J, Li J, Keiser J, et al., 2008, TREMATODE INDUCED CHANGES IN THE BRAIN METABOLIC PROFILE, 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene, Publisher: AMER SOC TROP MED & HYGIENE, Pages: 106-107, ISSN: 0002-9637
Li JV, Wang Y, Saric J, et al., 2008, Global metabolic responses of NMRI mice to an experimental <i>Plasmodium berghei</i> infection, JOURNAL OF PROTEOME RESEARCH, Vol: 7, Pages: 3948-3956, ISSN: 1535-3893
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- Citations: 61
Saric J, Li JV, Wang Y, et al., 2008, Metabolic profiling of an Echinostoma caproni infection in the mouse for biomarker discovery., PLoS Neglected Tropical Diseases, Vol: 2, Pages: 1-15, ISSN: 1935-2727
BackgroundMetabolic profiling holds promise with regard to deepening our understanding of infection biology and disease states. The objectives of our study were to assess the global metabolic responses to an Echinostoma caproni infection in the mouse, and to compare the biomarkers extracted from different biofluids (plasma, stool, and urine) in terms of characterizing acute and chronic stages of this intestinal fluke infection.Methodology/Principal FindingsTwelve female NMRI mice were infected with 30 E. caproni metacercariae each. Plasma, stool, and urine samples were collected at 7 time points up to day 33 post-infection. Samples were also obtained from non-infected control mice at the same time points and measured using 1H nuclear magnetic resonance (NMR) spectroscopy. Spectral data were subjected to multivariate statistical analyses. In plasma and urine, an altered metabolic profile was already evident 1 day post-infection, characterized by reduced levels of plasma choline, acetate, formate, and lactate, coupled with increased levels of plasma glucose, and relatively lower concentrations of urinary creatine. The main changes in the urine metabolic profile started at day 8 post-infection, characterized by increased relative concentrations of trimethylamine and phenylacetylglycine and lower levels of 2-ketoisocaproate and showed differentiation over the course of the infection.Conclusion/SignificanceThe current investigation is part of a broader NMR-based metabonomics profiling strategy and confirms the utility of this approach for biomarker discovery. In the case of E. caproni, a diagnosis based on all three biofluids would deliver the most comprehensive fingerprint of an infection. For practical purposes, however, future diagnosis might aim at a single biofluid, in which case urine would be chosen for further investigation, based on quantity of biomarkers, ease of sampling, and the degree of differentiation from the non-infected control group.
Li JV, Saric J, Wang Y, et al., 2008, Metabolic profiling of co-infection of Trypanosoma brucei brucei strains in mice, Gordon Research Conferences: Host-Parasite Interactions
Wang Y, Utzinger J, Saric J, et al., 2008, Global metabolic responses of mice to Trypanosoma brucei brucei infection, Proceedings of the National Academy of Sciences USA, Vol: 105, Pages: 6127-6132
Saric J, Li JV, Wang Y, et al., 2008, Use of Echinostoma spp. in studies on chemotherapy and metabolic profiling
Yap IKS, Li JV, Saric J, et al., 2008, Metabonomic and microbiological analysis of the dynamic effect of vancomycin-induced gut microbiota modification in the mouse, Journal of Proteome Research, Vol: 7, Pages: 3718-3728
Saric J, Wang Y, Li JV, et al., 2007, Species variation in the fecal metabolome gives insight into differential gastrointestinal function, Journal of Proteome Research, Vol: 7, Pages: 352-360
Li J, Wang Y, Fenwick A, et al., 2007, A high-performance liquid chromatography and nuclear magnetic resonance spectroscopy-based analysis of commercially available praziquantel tablets, Journal of Pharmaceutical and Biomedical Analysis, Vol: 45, Pages: 263-267
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