Imperial College London
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Dr. Jia Li

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Reader in Biological Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 3230jia.li

 
 
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Location

 

10.N2ACommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Guo:2020:ageing/afz132,
author = {Guo, Y and Li, Y and Zhang, Y and Fang, S and Xu, X and Zhao, A and Zhang, J and Li, J and Ma, D and Jia, W and Jiang, W},
doi = {ageing/afz132},
journal = {Age and Ageing},
pages = {88--95},
title = {Post-operative delirium associated with metabolic alterations following hemi-arthroplasty in older patients},
url = {http://dx.doi.org/10.1093/ageing/afz132},
volume = {49},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Backgroundpost-operative delirium (POD) is a common complication in older patients, though a possible link between metabolic changes and POD development has yet to be investigated.Methodsolder patients with hip fracture who underwent hemi-arthroplasty were recruited, and delirious states were assessed for 3 days after surgery using the confusion assessment method-Chinese revision. Simultaneously, fasting blood samples were collected on the morning of surgery and on the first post-operative day. Ultimately, 244 older patients who met the inclusion and exclusion criteria were assessed. Blood samples from 60 patients with POD and 60 matched controls were analysed using metabolomics platforms.Resultssixty patients (24.6%) developed POD. Principal component analysis scores plot and cross-validated scores plots from orthogonal partial least squares-discriminant analysis were implemented to visualise the differences in metabolites between the two groups before and after surgery (P < 0.05). Our data indicate that levels of ω3 and ω6 fatty acids were lower in the POD group than in the NPOD (non-POD) group both before and after surgery; tricarboxylic cycle intermediate levels were lower in the POD group than in the NPOD group, but glycolysis products were higher in the POD group than in the NPOD group after surgery. Furthermore, the branched-chain amino acid (BCAA)/aromatic amino acid ratio was lower in the POD group than in the NPOD group after surgery.Conclusionsmetabolic abnormalities, including deficiencies in ω3 and ω6 fatty acids, perturbations in tricarboxylic cycle and oxidative stress and metabolic imbalances in BCAA and AAA might contribute to POD development.
AU  - Guo,Y
AU  - Li,Y
AU  - Zhang,Y
AU  - Fang,S
AU  - Xu,X
AU  - Zhao,A
AU  - Zhang,J
AU  - Li,J
AU  - Ma,D
AU  - Jia,W
AU  - Jiang,W
DO  - ageing/afz132
EP  - 95
PY  - 2020///
SN  - 0002-0729
SP  - 88
TI  - Post-operative delirium associated with metabolic alterations following hemi-arthroplasty in older patients
T2  - Age and Ageing
UR  - http://dx.doi.org/10.1093/ageing/afz132
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000518555200017&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://academic.oup.com/ageing/article/49/1/88/5618815
UR  - http://hdl.handle.net/10044/1/82940
VL  - 49
ER  -
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