Imperial College London
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Dr. Jia Li

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Reader in Biological Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 3230jia.li

 
 
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Location

 

10.N2ACommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Amin:2021:10.1111/dom.14204,
author = {Amin, A and Frampton, J and Liu, Z and Franco-Becker, G and Norton, M and Alaa, A and Li, JV and Murphy, KG},
doi = {10.1111/dom.14204},
journal = {Diabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics},
pages = {147--157},
title = {Differential effects of L- and D-phenylalanine on pancreatic and gastrointestinal hormone release in humans: a randomised crossover study.},
url = {http://dx.doi.org/10.1111/dom.14204},
volume = {23},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - AIMS: High-protein meals stimulate pancreatic hormone release, and high-protein diets improve glucose homeostasis and decrease energy intake. These effects are partly mediated by gastrointestinal sensing of the amino acid products of protein digestion, including L-phenylalanine. Animal models suggest the calcium-sensing receptor mediates the glycaemic and anorectic effects of L-phenylalanine. However, there is conflicting evidence regarding L-phenylalanine on appetite, and the specificity of its effects on hormone release. MATERIALS & METHODS: Dose-finding study: non-randomised, unblinded, crossover study conducted October 2017 to December 2017 at the NIHR Imperial Clinical Research Facility in 5 participants. Assessed the tolerability of escalating doses of oral L-phenylalanine (0g, 3g, 6g, 10g). Acute study: randomised, double-blind, placebo-controlled crossover study conducted from January to May 2018 at the NIHR Imperial Clinical Research Facility in 11 participants. Investigated the effects of oral 10g L-phenylalanine relative to D-phenylalanine and placebo on gastroenteropancreatic hormone (insulin, glucagon, GIP, PYY, GLP-1) and glucose concentrations, visual analogue scales for subjective appetite and energy intake at an ad libitum meal served 70 minutes post-ingestion. RESULTS: L-phenylalanine was well-tolerated and increased insulin and glucagon concentrations prior to meal ingestion at several timepoints relative to placebo and D-phenylalanine (P<0.05). L-phenylalanine also increased GIP concentrations relative to D-phenylalanine (P=0.0420) and placebo (P=0.0249) 70 minutes following ingestion. L-phenylalanine reduced postprandial glucose AUC70-150mins relative to placebo (P=0.0317) but did not affect subjective appetite or energy intake (P>0.05). D-phenylalanine increased postprandial PYY AUC70-150mins concentrations relative to placebo (P=0.0002). CONCLUSIONS: Ingestion of L-phenylalanine, but not D-phenylalanine, increases insulin, glucagon a
AU  - Amin,A
AU  - Frampton,J
AU  - Liu,Z
AU  - Franco-Becker,G
AU  - Norton,M
AU  - Alaa,A
AU  - Li,JV
AU  - Murphy,KG
DO  - 10.1111/dom.14204
EP  - 157
PY  - 2021///
SN  - 1462-8902
SP  - 147
TI  - Differential effects of L- and D-phenylalanine on pancreatic and gastrointestinal hormone release in humans: a randomised crossover study.
T2  - Diabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics
UR  - http://dx.doi.org/10.1111/dom.14204
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32991046
UR  - https://dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.14204
UR  - http://hdl.handle.net/10044/1/83072
VL  - 23
ER  -
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