Imperial College London
Portrait Picture

Dr. Jia Li

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Reader in Biological Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 3230jia.li

 
 
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Location

 

10.N2ACommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@inbook{Li:2018:10.1039/9781782627937-00264,
author = {Li, JV and Saric, J and Sabrina, D},
booktitle = {NMR-based Metabolomics},
doi = {10.1039/9781782627937-00264},
editor = {Keun},
publisher = {Royal Society of Chemistry},
title = {1H NMR-based Metabolic Profiling in Infectious Disease Research},
url = {http://dx.doi.org/10.1039/9781782627937-00264},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - CHAP
AB  - This chapter highlights the application of 1H NMR spectroscopy-based metabolic profiling in infection research, specifically on HIV/AIDS, tuberculosis, malaria and the neglected tropical diseases, such as Schistosomiasis. We describe the use of this approach to investigate the metabolic responses of the host to infectious agents in both in vivo and in vitro models, as well in natural human infections. These metabolic signatures hold significant promise in leading to early and robust diagnosis of a range infectious diseases, including parasitic infections, where often a unique set of metabolites has been found to be associated with infection. In addition, metabolic profiling, together with measures of immune responses and gut microbial composition, provides mechanistic insight into the pathogen–host interactions through the immune–gut microbiota–metabolic axis.
AU  - Li,JV
AU  - Saric,J
AU  - Sabrina,D
DO  - 10.1039/9781782627937-00264
PB  - Royal Society of Chemistry
PY  - 2018///
SN  - 9781849736435
TI  - 1H NMR-based Metabolic Profiling in Infectious Disease Research
T1  - NMR-based Metabolomics
UR  - http://dx.doi.org/10.1039/9781782627937-00264
ER  -
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