Imperial College London

ProfessorJimmyBell

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 3506 4608jimmy.bell Website

 
 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

340 results found

Mackenzie AM, Smith HE, Mould RR, Bell JD, Nunn AVW, Botchway SWet al., 2024, Rooting out ultraweak photon emission a-mung bean sprouts, Journal of Photochemistry and Photobiology, Vol: 19, Pages: 100224-100224, ISSN: 2666-4690

Journal article

Heymsfield S, Bell JD, Heber D, 2024, Phenotyping, Body Composition, and Precision Nutrition, Precision Nutrition, Publisher: Elsevier, Pages: 143-152, ISBN: 9780443153150

Book chapter

Aguida B, Chabi M-M, Baouz S, Mould R, Bell JD, Pooam M, André S, Archambault D, Ahmad M, Jourdan Net al., 2023, Near-Infrared Light Exposure Triggers ROS to Downregulate Inflammatory Cytokines Induced by SARS-CoV-2 Spike Protein in Human Cell Culture., Antioxidants (Basel), Vol: 12, ISSN: 2076-3921

The leading cause of mortality from SARS-CoV-2 is an exaggerated host immune response, triggering cytokine storms, multiple organ failure and death. Current drug- and vaccine-based therapies are of limited efficacy against novel viral variants. Infrared therapy is a non-invasive and safe method that has proven effective against inflammatory conditions for over 100 years. However, its mechanism of action is poorly understood and has not received widespread acceptance. We herein investigate whether near-infrared (NIR) light exposure in human primary alveolar and macrophage cells could downregulate inflammatory cytokines triggered by the SARS-CoV-2 spike (S) protein or lipopolysaccharide (LPS), and via what underlying mechanism. Our results showed a dramatic reduction in pro-inflammatory cytokines within days of NIR light treatment, while anti-inflammatory cytokines were upregulated. Mechanistically, NIR light stimulated mitochondrial metabolism, induced transient bursts in reactive oxygen species (ROS) and activated antioxidant gene transcription. These, in turn, downregulated ROS and inflammatory cytokines. A causal relationship was shown between the induction of cellular ROS by NIR light exposure and the downregulation of inflammatory cytokines triggered by SARS-CoV-2 S. If confirmed by clinical trials, this method would provide an immediate defense against novel SARS-CoV-2 variants and other inflammatory infectious diseases.

Journal article

Rundle M, Fiamoncini J, Thomas EL, Wopereis S, Afman LA, Brennan L, Drevon CA, Gundersen TE, Daniel H, Perez IG, Posma JM, Ivanova DG, Bell JD, van Ommen B, Frost Get al., 2023, Diet-induced Weight Loss and Phenotypic Flexibility Among Healthy Overweight Adults: A Randomized Trial, AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol: 118, Pages: 591-604, ISSN: 0002-9165

Journal article

Nunn AVW, Guy GW, Bell JD, 2023, Informing the Cannabis Conjecture: From Life's Beginnings to Mitochondria, Membranes and the Electrome-A Review, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol: 24, ISSN: 1661-6596

Journal article

Brown AA, Fernandez-Tajes JJ, Hong M-G, Brorsson CA, Koivula RW, Davtian D, Dupuis T, Sartori A, Michalettou T-D, Forgie IM, Adam J, Allin KH, Caiazzo R, Cederberg H, De Masi F, Elders PJM, Giordano GN, Haid M, Hansen T, Hansen TH, Hattersley AT, Heggie AJ, Howald C, Jones AG, Kokkola T, Laakso M, Mahajan A, Mari A, Mcdonald TJ, Mcevoy D, Mourby M, Musholt PB, Nilsson B, Pattou F, Penet D, Raverdy V, Ridderstrale M, Romano L, Rutters F, Sharma S, Teare H, 't Hart L, Tsirigos KD, Vangipurapu J, Vestergaard H, Brunak S, Franks PW, Frost G, Grallert H, Jablonka B, Mccarthy MI, Pavo I, Pedersen O, Ruetten H, Walker M, Adragni K, Allesoe RLL, Artati AA, Arumugam M, Atabaki-Pasdar N, Baltauss T, Banasik K, Barnett AL, Baum P, Bell JD, Beulens JW, Bianzano SB, Bizzotto R, Bonnefond A, Cabrelli L, Dale M, Dawed AY, de Preville N, Dekkers KF, Deshmukh HA, Dings C, Donnelly L, Dutta A, Ehrhardt B, Engelbrechtsen L, Eriksen R, Fan Y, Ferrer J, Fitipaldi H, Forman A, Fritsche A, Froguel P, Gassenhuber J, Gough S, Graefe-Mody U, Grempler R, Groeneveld L, Groop L, Gudmundsdottir V, Gupta R, Hennige AMH, Hill AV, Holl RW, Hudson M, Jacobsen UP, Jennison C, Johansen J, Jonsson A, Karaderi T, Kaye J, Kennedy G, Klintenberg M, Kuulasmaa T, Lehr T, Loftus H, Lundgaard ATT, Mazzoni G, Mcrobert N, Mcvittie I, Nice R, Nicolay C, Nijpels G, Palmer CN, Pedersen HK, Perry MH, Pomares-Millan H, Prehn CP, Ramisch A, Rasmussen S, Robertson N, Rodriquez M, Sackett P, Scherer N, Shah N, Sihinevich I, Slieker RC, Sondertoft NB, Steckel-Hamann B, Thomas MK, Thomas CEE, Thomas ELL, Thorand B, Thorne CE, Tillner J, Tura A, Uhlen M, van Leeuwen N, van Oort S, Verkindt H, Vogt J, Wad Sackett PW, Wesolowska-Andersen A, Whitcher B, White MW, Adamski J, Schwenk JM, Pearson ER, Dermitzakis ET, Vinuela Aet al., 2023, Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits, NATURE COMMUNICATIONS, Vol: 14

Journal article

Basty ND, Sorokin E, Thanaj M, Srinivasan R, Whitcher B, Bell J, Cule M, Thomas ELet al., 2023, Abdominal imaging associates body composition with COVID-19 severity, PLOS ONE, Vol: 18, ISSN: 1932-6203

Journal article

Mould RR, Kalampouka I, Thomas EL, Guy GW, Nunn AVW, Bell JDet al., 2023, Non-chemical signalling between mitochondria., Front Physiol, Vol: 14, ISSN: 1664-042X

A wide variety of studies have reported some form of non-chemical or non-aqueous communication between physically isolated organisms, eliciting changes in cellular proliferation, morphology, and/or metabolism. The sources and mechanisms of such signalling pathways are still unknown, but have been postulated to involve vibration, volatile transmission, or light through the phenomenon of ultraweak photon emission. Here, we report non-chemical communication between isolated mitochondria from MCF7 (cancer) and MCF10A (non-cancer) cell lines. We found that mitochondria in one cuvette stressed by an electron transport chain inhibitor, antimycin, alters the respiration of mitochondria in an adjacent, but chemically and physically separate cuvette, significantly decreasing the rate of oxygen consumption compared to a control (p = <0.0001 in MCF7 and MCF10A mitochondria). Moreover, the changes in O2-consumption were dependent on the origin of mitochondria (cancer vs. non-cancer) as well as the presence of "ambient" light. Our results support the existence of non-chemical signalling between isolated mitochondria. The experimental design suggests that the non-chemical communication is light-based, although further work is needed to fully elucidate its nature.

Journal article

Nunn AVW, Guy GW, Bell JD, 2022, Bioelectric fields at the beginnings of life, Bioelectricity, Vol: 4, Pages: 237-247, ISSN: 2576-3105

The consensus on the origins of life is that it involved organization of prebiotic chemicals according to the underlying principles of thermodynamics to dissipate energy derived from photochemical and/or geochemical sources. Leading theories tend to be chemistry-centric, revolving around either metabolism or information-containing polymers first. However, experimental data also suggest that bioelectricity and quantum effects play an important role in biology, which might suggest that a further factor is required to explain how life began. Intriguingly, in the early part of 20th century, the concept of the “morphogenetic field” was proposed by Gurwitsch to explain how the shape of an organism was determined, while a role for quantum mechanics in biology was suggested by Bohr and Schrödinger, among others. This raises the question as to the potential of these phenomena, especially bioelectric fields, to have been involved in the origin of life. It points to the possibility that as bioelectricity is universally prevalent in biological systems today, it represents a more complex echo of an electromagnetic skeleton which helped shape life into being. It could be argued that as a flow of ions creates an electric field, this could have been pivotal in the formation of an energy dissipating structure, for instance, in deep sea thermal vents. Moreover, a field theory might also hint at the potential involvement of nontrivial quantum effects in life. Not only might this perspective help indicate the origins of morphogenetic fields, but also perhaps suggest where life may have started, and whether metabolism or information came first. It might also help to provide an insight into aging, cancer, consciousness, and, perhaps, how we might identify life beyond our planet. In short, when thinking about life, not only do we have to consider the accepted chemistry, but also the fields that must also shape it. In effect, to fully understand life, as well as the yin of

Journal article

Woodley S, Butt J, Mould R, Kalampouka I, Booker A, Bell Jet al., 2022, Licorice Root Ameliorates Drug Induced Mitochondrial Stress in MCF7 and MCF10A Cells, Publisher: GEORG THIEME VERLAG KG, Pages: 1513-1513, ISSN: 0032-0943

Conference paper

Nunn AVW, Guy GW, Brysch W, Bell JDet al., 2022, Understanding Long COVID; Mitochondrial Health and Adaptation-Old Pathways, New Problems, BIOMEDICINES, Vol: 10

Journal article

O'Donovan SD, Erdos B, Jacobs DM, Wanders AJ, Thomas EL, Bell JD, Rundle M, Frost G, Arts ICW, Afman LA, van Riel NAWet al., 2022, Quantifying the contribution of triglycerides to metabolic resilience through the mixed meal model, ISCIENCE, Vol: 25

Journal article

Asaturyan HA, Basty N, Thanaj M, Whitcher B, Thomas EL, Bell JDet al., 2022, Improving the accuracy of fatty liver index to reflect liver fat content with predictive regression modelling, PLOS ONE, Vol: 17, ISSN: 1932-6203

Journal article

Thanaj M, Basty N, Cule M, Sorokin EP, Whitcher B, Bell JD, Thomas ELet al., 2022, Liver Shape Analysis using Statistical Parametric Maps at Population Scale

<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Morphometric image analysis enables the quantification of differences in the shape and size of organs between individuals.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Here we have applied morphometric methods to the study of the liver by constructing surface meshes from liver segmentations from abdominal MRI images in 33,434 participants in the UK Biobank. Based on these three dimensional mesh vertices, we evaluated local shape variations and modelled their association with anthropometric, phenotypic and clinical conditions, including liver disease and type-2 diabetes.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>We found that age, body mass index, hepatic fat and iron content, as well as, health traits were significantly associated with regional liver shape and size. Interaction models in groups with specific clinical conditions showed that the presence of type-2 diabetes accelerates age-related changes in the liver, while presence of liver fat further increased shape variations in both type-2 diabetes and liver disease.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The results suggest that this novel approach may greatly benefit studies aiming at better categorisation of pathologies associated with acute and chronic clinical conditions.</jats:p></jats:sec>

Journal article

Basty N, Sorokin EP, Thanaj M, Whitcher B, Liu Y, Bell JD, Thomas EL, Cule Met al., 2022, Cardiovascular measures from abdominal MRI provide insights into abdominal vessel genetic architecture

<jats:title>Abstract</jats:title><jats:p>Features extracted from cardiac MRI (CMR) are correlated with cardiovascular disease outcomes such as aneurysm, and have a substantial heritable component. To determine whether disease-relevant measurements are feasible in non-cardiac specific MRI, and to explore their associations with disease outcomes, and genetic and environmental risk factors. We segmented the heart, aorta, and vena cava from abdominal MRI scans using deep learning, and generated six image-derived phenotypes (IDP): heart volume, four aortic and one vena cava cross-sectional areas (CSA), from 44,541 UK Biobank participants. We performed genome- and phenome-wide association studies, and constructed a polygenic risk score for each phenotype. We demonstrated concordance between our IDPs and related IDPs from CMR, the current gold standard. We replicated previous findings related to sex differences and age-related changes in heart and vessel dimensions. We identified a significant association between infrarenal descending aorta CSA and incident abdominal aortic aneurysm, and between heart volume and several cardiovascular disorders. In a GWAS, we identified 72 associations at 59 loci (15 novel). We derived a polygenic risk score for each trait and demonstrated an association with TAA diagnosis, pointing to a potential screening method for individuals at high-risk of this condition. We demonstrated substantial genetic correlation with cardiovascular traits including aneurysms, varicose veins, dysrhythmia, and cardiac failure. Finally, heritability enrichment analysis implicated vascular tissue in the heritability of these traits. Our work highlights the value of non-specific MRI for exploring cardiovascular disease risk in cohort studies.</jats:p>

Journal article

Fiamoncini J, Donado-Pestana CM, Duarte GBS, Rundle M, Thomas EL, Kiselova-Kaneva Y, Gundersen TE, Bunzel D, Trezzi J-P, Kulling SE, Hiller K, Sonntag D, Ivanova D, Brennan L, Wopereis S, van Ommen B, Frost G, Bell J, Drevon CA, Daniel Het al., 2022, Plasma Metabolic Signatures of Healthy Overweight Subjects Challenged With an Oral Glucose Tolerance Test, FRONTIERS IN NUTRITION, Vol: 9, ISSN: 2296-861X

Journal article

Sorokin E, Basty N, Whitcher B, Liu Y, Bell JD, Cohen R, Cule M, Thomas Let al., 2022, Analysis of MRI-derived spleen iron in the UK Biobank identifies genetic variation linked to iron homeostasis and erythrocyte morphology, American Journal of Human Genetics, Vol: 109, Pages: 1092-1104, ISSN: 0002-9297

The spleen plays a key role in iron homeostasis. It is the largest filter of the blood and performs iron reuptake from old or damaged erythrocytes. Despite this role, spleen iron concentration has not been measured in a large, population-based cohort. In this study, we quantify spleen iron in 41,764 participants of the UK Biobank using magnetic resonance imaging, and provide the first reference range for spleen iron in an unselected population. Through genome-wide association study, we identify associations between spleen iron and regulatory variation at two hereditary spherocytosis genes, ANK1 and SPTA1 . Spherocytosis-causing coding mutations in these genes are associated with lower reticulocyte volume and increased reticulocyte percentage, while these novel common alleles are associated with increased expression of ANK1 and SPTA1 in blood and with larger reticulocyte volume and reduced reticulocyte percentage. As genetic modifiers, these common alleles may explain mild spherocytosis phenotypes that have been observed clinically. Our genetic study also identifies a signal which co-localizes with a splicing quantitative trait locus for MS4A7 , and we show this gene is abundantly expressed in the spleen and in macrophages. The combination of deep learning and efficient image processing enables non-invasive measurement of spleen iron and, in turn, characterization of genetic factors related to iron recycling and erythrocyte morphology.

Journal article

Martin S, Tyrrell J, Thomas EL, Bown MJ, Wood AR, Beaumont RN, Tsoi LC, Stuart PE, Elder JT, Law P, Houlston R, Kabrhel C, Papadimitriou N, Gunter M, Bull C, Bell JA, Vincent EE, Sattar N, Dunlop MG, Tomlinson IPM, Lindström S, INVENT consortium, Bell JD, Frayling T, Yaghootkar Het al., 2022, Correction: Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation., Elife, Vol: 11

Journal article

Whitcher B, Thanaj M, Cule M, Liu Y, Basty N, Sorokin E, Bell JD, Thomas Let al., 2022, Precision MRI phenotyping enables detection of small changes in body composition for longitudinal cohorts, Scientific Reports, Vol: 12, ISSN: 2045-2322

Longitudinal studies provide unique insights into the impact of environmental factors and lifespan issues on health and disease. Here we investigate changes in body composition in 3088 free-living participants, part of the UK Biobank in-depth imaging study. All participants underwent neck-to-knee MRI scans at the first imaging visit and after approximately two years (second imaging visit). Image-derived phenotypes for each participant were extracted using a fully-automated image processing pipeline, including volumes of several tissues and organs: liver, pancreas, spleen, kidneys, total skeletal muscle, iliopsoas muscle, visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue, as well as fat and iron content in liver, pancreas and spleen. Overall, no significant changes were observed in BMI, body weight, or waist circumference over the scanning interval, despite some large individual changes. A significant decrease in grip strength was observed, coupled to small, but statistically significant, decrease in all skeletal muscle measurements. Significant increases in VAT and intermuscular fat in the thighs were also detected in the absence of changes in BMI, waist circumference and ectopic-fat deposition. Adjusting for disease status at the first imaging visit did not have an additional impact on the changes observed. In summary, we show that even after a relatively short period of time significant changes in body composition can take place, probably reflecting the obesogenic environment currently inhabited by most of the general population in the United Kingdom.

Journal article

Basty N, Sorokin EP, Thanaj M, Srinivasan R, Whitcher B, Bell JD, Cule M, Thomas ELet al., 2022, Abdominal Imaging Associates Body Composition with COVID-19 Severity

<jats:title>Abstract</jats:title><jats:p>The main drivers of COVID-19 disease severity and the impact of COVID-19 on long-term health after recovery are yet to be fully understood. Medical imaging studies investigating COVID-19 to date have mostly been limited to small datasets and post-hoc analyses of severe cases. The UK Biobank recruited recovered SARS-CoV-2 positive individuals (n=967) and matched controls (n=913) who were extensively imaged prior to the pandemic and underwent follow-up scanning. In this study, we investigated longitudinal changes in body composition, as well as the associations of pre-pandemic image-derived phenotypes with COVID-19 severity. Our longitudinal analysis, in a population of mostly mild cases, associated a decrease in lung volume with SARS-CoV-2 positivity. We also observed that increased visceral adipose tissue and liver fat, and reduced muscle volume, prior to COVID-19, were associated with COVID-19 disease severity. Finally, we trained a machine classifier with demographic, anthropometric and imaging traits, and showed that visceral fat, liver fat and muscle volume have prognostic value for COVID-19 disease severity beyond the standard demographic and anthropometric measurements. This combination of image-derived phenotypes from abdominal MRI scans and ensemble learning to predict risk may have future clinical utility in identifying populations at-risk for a severe COVID-19 outcome.</jats:p>

Journal article

Nunn AVW, Guy GW, Bell JD, 2022, Thermodynamics and inflammation: insights into quantum biology and ageing, Quantum Reports, Vol: 4, Pages: 47-74, ISSN: 2624-960X

Inflammation as a biological concept has been around a long time and derives from the Latin “to set on fire” and refers to the redness and heat, and usually swelling, which accompanies injury and infection. Chronic inflammation is also associated with ageing and is described by the term “inflammaging”. Likewise, the biological concept of hormesis, in the guise of what “does not kill you, makes you stronger”, has long been recognized, but in contrast, seems to have anti-inflammatory and age-slowing characteristics. As both phenomena act to restore homeostasis, they may share some common underlying principles. Thermodynamics describes the relationship between heat and energy, but is also intimately related to quantum mechanics. Life can be viewed as a series of self-renewing dissipative structures existing far from equilibrium as vortexes of “negentropy” that ages and dies; but, through reproduction and speciation, new robust structures are created, enabling life to adapt and continue in response to ever changing environments. In short, life can be viewed as a natural consequence of thermodynamics to dissipate energy to restore equilibrium; each component of this system is replaceable. However, at the molecular level, there is perhaps a deeper question: is life dependent on, or has it enhanced, quantum effects in space and time beyond those normally expected at the atomistic scale and temperatures that life operates at? There is some evidence it has. Certainly, the dissipative adaptive mechanism described by thermodynamics is now being extended into the quantum realm. Fascinating though this topic is, does exploring the relationship between quantum mechanics, thermodynamics, and biology give us a greater insight into ageing and, thus, medicine? It could be said that hormesis and inflammation are expressions of thermodynamic and quantum principles that control ageing via natural selection that could operate at all scales

Journal article

Martin S, Tyrrell J, Thomas EL, Bown MJ, Wood AR, Beaumont RN, Tsoi LC, Stuart PE, Elder JT, Law P, Houlston R, Kabrhel C, Papadimitriou N, Gunter MJ, Bull CJ, Bell JA, Vincent EE, Sattar N, Dunlop MG, Tomlinson IPM, Bell JD, Frayling TM, Yaghootkar Het al., 2022, Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation, ELIFE, Vol: 11, ISSN: 2050-084X

Journal article

Wesolowska-Andersen A, Brorsson CA, Bizzotto R, Mari A, Tura A, Koivula R, Mahajan A, Vinuela A, Tajes JF, Sharma S, Haid M, Prehn C, Artati A, Hong M-G, Musholt PB, Kurbasic A, De Masi F, Tsirigos K, Pedersen HK, Gudmundsdottir V, Thomas CE, Banasik K, Jennison C, Jones A, Kennedy G, Bell J, Thomas L, Frost G, Thomsen H, Allin K, Hansen TH, Vestergaard H, Hansen T, Rutters F, Elders P, T'Hart L, Bonnefond A, Canouil M, Brage S, Kokkola T, Heggie A, McEvoy D, Hattersley A, McDonald T, Teare H, Ridderstrale M, Walker M, Forgie I, Giordano GN, Froguel P, Pavo I, Ruetten H, Pedersen O, Dermitzakis E, Franks PW, Schwenk JM, Adamski J, Pearson E, McCarthy M, Brunak Set al., 2022, Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study, CELL REPORTS MEDICINE, Vol: 3, ISSN: 2666-3791

Journal article

Mould RR, Thomas EL, Guy G, Nunn AVW, Bell JDet al., 2022, Cell-cell death communication by signals passing through non-aqueous environments: A reply, RESULTS IN CHEMISTRY, Vol: 4, ISSN: 2211-7156

Journal article

Whitcher B, Thanaj M, Cule M, Liu Y, Basty N, Sorokin EP, Bell JD, Thomas ELet al., 2021, Precision MRI Phenotyping Enables Detection of Small Changes in Body Composition for Longitudinal Cohorts

<jats:title>ABSTRACT</jats:title><jats:p>Longitudinal studies provide unique insights into the impact of environmental factors and lifespan issues on health and disease. Here we investigate changes in body composition in 3,088 free-living participants, part of the UK Biobank in-depth imaging study. All participants underwent neck-to-knee MRI scans at the first imaging visit and after approximately two years (second imaging visit). Image-derived phenotypes for each participant were extracted using a fully-automated image processing pipeline, including volumes of several tissues and organs: liver, pancreas, spleen, kidneys, total skeletal muscle, iliopsoas muscle, visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue (ASAT), as well as fat and iron content in liver, pancreas and spleen. Overall, no significant changes were observed in BMI, body weight, or waist circumference over the scanning interval, despite some large individual changes. A significant decrease in grip strength was observed, coupled to small, but statistically significant, decrease in all skeletal muscle measurements. Significant increases in VAT and intermuscular fat in the thighs were also detected in the absence of changes in BMI, waist circumference and ectopic-fat deposition. Adjusting for disease status at the first imaging visit did not have an additional impact on the changes observed. In summary, we show that even after a relatively short period of time significant changes in body composition can take place, probably reflecting the obesogenic environment currently inhabited by most of the general population in the United Kingdom.</jats:p>

Working paper

Liu Y, Basty N, Whitcher B, Bell JD, Sorokin EP, van Bruggen N, Thomas EL, Cule Met al., 2021, Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning, eLife, Vol: 10, ISSN: 2050-084X

Cardiometabolic diseases are an increasing global health burden. While socioeconomic, environmental, behavioural, and genetic risk factors have been identified, a better understanding of the underlying mechanisms is required to develop more effective interventions. Magnetic resonance imaging (MRI) has been used to assess organ health, but biobank-scale studies are still in their infancy. Using over 38,000 abdominal MRI scans in the UK Biobank, we used deep learning to quantify volume, fat, and iron in seven organs and tissues, and demonstrate that imaging-derived phenotypes reflect health status. We show that these traits have a substantial heritable component (8–44%) and identify 93 independent genome-wide significant associations, including four associations with liver traits that have not previously been reported. Our work demonstrates the tractability of deep learning to systematically quantify health parameters from high-throughput MRI across a range of organs and tissues, and use the largest-ever study of its kind to generate new insights into the genetic architecture of these traits.

Journal article

Woodley SB, Mould RR, Sahuri-Arisoylu M, Kalampouka I, Booker A, Bell JDet al., 2021, Mitochondrial Function as a Potential Tool for Assessing Function, Quality and Adulteration in Medicinal Herbal Teas, FRONTIERS IN PHARMACOLOGY, Vol: 12

Journal article

Bizzotto R, Jennison C, Jones AG, Kurbasic A, Tura A, Kennedy G, Bell JD, Thomas EL, Frost G, Eriksen R, Koivula RW, Brage S, Kaye J, Hattersley AT, Heggie A, McEvoy D, 't Hart LM, Beulens JW, Elders P, Musholt PB, Ridderstrale M, Hansen TH, Allin KH, Hansen T, Vestergaard H, Lundgaard AT, Thomsen HS, De Masi F, Tsirigos KD, Brunak S, Vinuela A, Mahajan A, McDonald TJ, Kokkola T, Forgie IM, Giordano GN, Pavo I, Ruetten H, Dermitzakis E, McCarthy MI, Pedersen O, Schwenk JM, Adamski J, Franks PW, Walker M, Pearson ER, Mari Aet al., 2021, Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study, DIABETES CARE, Vol: 44, Pages: 511-518, ISSN: 0149-5992

Journal article

Villarini B, Asaturyan H, Kurugol S, Afacan O, Bell JD, Thomas ELet al., 2021, 3D Deep Learning for Anatomical Structure Segmentation in Multiple Imaging Modalities, 34th IEEE International Symposium on Computer-Based Medical Systems (IEEE CBMS), Publisher: IEEE, Pages: 166-171, ISSN: 2372-9198

Conference paper

Fitzpatrick JA, Basty N, Cule M, Liu Y, Bell JD, Thomas EL, Whitcher Bet al., 2020, Large-scale analysis of iliopsoas muscle volumes in the UK Biobank, SCIENTIFIC REPORTS, Vol: 10, ISSN: 2045-2322

Journal article

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