Publications
348 results found
Barnard ML, Schwieso JE, Thomas EL, et al., 1996, Development of a rapid and efficient magnetic resonance imaging technique for analysis of body fat distribution, NMR IN BIOMEDICINE, Vol: 9, Pages: 156-164, ISSN: 0952-3480
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- Citations: 22
Tate AR, Watson D, Eglen S, et al., 1996, Automated feature extraction for the classification of human in vivo C-13 NMR spectra using statistical pattern recognition and wavelets, MAGNETIC RESONANCE IN MEDICINE, Vol: 35, Pages: 834-840, ISSN: 0740-3194
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- Citations: 15
AlaKorpela M, Hiltunen Y, Bell JD, 1996, Artificial neural network analysis of H-1 nuclear magnetic resonance spectroscopic data from human plasma, ANTICANCER RESEARCH, Vol: 16, Pages: 1473-1477, ISSN: 0250-7005
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- Citations: 13
Hanrahan JD, Sargentoni J, Azzopardi D, et al., 1996, Cerebral metabolism within 18 hours of birth asphyxia: A proton magnetic resonance spectroscopy study, PEDIATRIC RESEARCH, Vol: 39, Pages: 584-590, ISSN: 0031-3998
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- Citations: 90
Thomas EL, Frost G, Barnard ML, et al., 1996, An in vivo C-13 magnetic resonance spectroscopic study of the relationship between diet and adipose tissue composition, LIPIDS, Vol: 31, Pages: 145-151, ISSN: 0024-4201
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- Citations: 24
Hanrahan JD, Sargentoni J, Azzopardi D, et al., 1996, Cerebral metabolism within 18 hours of birth asphyxia: A proton magnetic resonance spectroscopy study, Pediatric Research, Vol: 39, Pages: 584-590, ISSN: 0031-3998
Proton magnetic resonance spectroscopy (1H MRS) was performed within 18 h of birth (median 13, range 4-18 h) on 16 term infants with clinical features of birth asphyxia. Ten infants with no evidence of birth asphyxia were studied as controls at 5-18 (median 8) h after birth. To detect delayed impairments in cerebral energy metabolism, 15 infants suspected of asphyxia underwent 31P MRS at 33-106 (median 62) h of age. Choline, creatine, and N-acetylaspartate (NAA) were detected in spectra located to the basal ganglia in all infants. Lactate was detected in 15 of the 16 infants suspected of asphyxia, but in only 4 of the 10 controls (p < 0.05, χ2). Glutamine and glutamate (Glx) was detected in 11 infants suspected of asphyxia and in three controls, but this difference was not significant at the 5% level. The spectra revealed no other significant differences between asphyxiated infants and controls. In the asphyxiated infants, there was a negative correlation between the ratio of lactate to creatine in the first 18 h of life and phosphocreatine/inorganic phosphate (PCr/P(i)) at 33-106 h (p < 0.001). Five severely asphyxiated infants had PCr/P(i) < 0.75 (median 0.53, range 0.14-0.65), indicating a poor neurodevelopmental prognosis, and a further infant died before PCr/P(i) could be measured. Ten infants had PCr/P(i) > 0.75 (1.03, 0.76-1.49). Median lactate/creatine was 1.47 (range 0.67-3.81) in the six severely affected subjects, 0.38 (0-1.51) in the latter group, and 0 (0-0.6) in controls (p < 0.0005, Kruskall-Wallis). These results suggest that, after birth asphyxia, cerebral energy metabolism is abnormal during the period when 31P MRS characteristically gives normal results. 1H MRS might be of value in predicting which infants are likely to suffer a decline in cerebral high energy phosphate concentrations and subsequent neurodevelopmental impairment.
TAYLORROBINSON SD, THOMAS EL, SARGENTONI J, et al., 1995, CIRRHOSIS OF THE HUMAN LIVER - AN IN-VITRO P-31 NUCLEAR-MAGNETIC-RESONANCE STUDY, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, Vol: 1272, Pages: 113-118, ISSN: 0925-4439
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- Citations: 35
AlaKorpela M, Hiltunen Y, Bell JD, 1995, Quantification of biomedical NMR data using artificial neural network analysis: Lipoprotein lipid profiles from H-1 NMR data of human plasma, NMR IN BIOMEDICINE, Vol: 8, Pages: 235-244, ISSN: 0952-3480
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- Citations: 37
CHUNG YL, WILLIAMS A, BEECH JS, et al., 1995, MRI ASSESSMENT OF THE BLOOD-BRAIN-BARRIER IN A HAMSTER MODEL OF SCRAPIE, NEURODEGENERATION, Vol: 4, Pages: 203-207, ISSN: 1055-8330
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- Citations: 21
MENON DK, SARGENTONI J, TAYLORROBINSON SD, et al., 1995, EFFECT OF FUNCTIONAL GRADE AND ETIOLOGY ON IN-VIVO HEPATIC P-31 MAGNETIC-RESONANCE SPECTROSCOPY IN CIRRHOSIS - BIOCHEMICAL BASIS OF SPECTRAL APPEARANCES, HEPATOLOGY, Vol: 21, Pages: 417-427, ISSN: 0270-9139
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- Citations: 90
Taylor-Robinson SD, Bell JD, Sargentoni J, et al., 1994, Cerebral 31P MRS in patients with chronic hepatic encephalopathy., Advances in Hepatic Encephalopathy and Metabolic Nitrogen Exchange, Editors: Capocaccia, Merli, Riggio, Boca Raton, Publisher: CRC Press, Pages: 372-377, ISBN: 084938964X
This is a comprehensive reference covering the advances in hepatic encephalopathy (HE) and metabolic nitrogen exchange.
TAYLORROBINSON SD, SARGENTONI J, MALLALIEU RJ, et al., 1994, CEREBRAL P-31 MAGNETIC-RESONANCE SPECTROSCOPY IN PATIENTS WITH CHRONIC HEPATIC-ENCEPHALOPATHY, HEPATOLOGY, Vol: 20, Pages: 1173-1178, ISSN: 0270-9139
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- Citations: 51
Cunnane SC, Williams SC, Bell JD, et al., 1994, Utilization of uniformly labeled 13C-polyunsaturated fatty acids in the synthesis of long-chain fatty acids and cholesterol accumulating in the neonatal rat brain., J Neurochem, Vol: 62, Pages: 2429-2436, ISSN: 0022-3042
Polyunsaturated fatty acids are needed for normal neonatal brain development, but the degree of conversion of the 18-carbon polyunsaturated fatty acid precursors consumed in the diet to their respective 20- and 22-carbon polyunsaturates accumulating in the brain is not well known. In the present study, in vivo 13C nuclear magnetic resonance spectroscopy was used to monitor noninvasively the brain uptake and metabolism of a mixture of uniformly 13C-enriched 16- and 18-carbon polyunsaturated fatty acid methyl esters injected intragastrically into neonatal rats. In vivo NMR spectra of the rat brain at postnatal days 10 and 17 had larger fatty acid signals than in uninjected controls, but changes in levels of individual fatty acids could not be distinguished. One day after injection of the U-13C-polyunsaturated fatty acid mixture, 13C enrichment (measured by isotope ratio mass spectrometry) was similar in brain phospholipids, free fatty acids, free cholesterol, and brain aqueous extract; 13C enrichment remained high in the phospholipids and cholesterol for 15 days. 13C enrichment was similar in the main fatty acids of the brain within 1 day of injection but 15 days later had declined in all except arachidonic acid while continuing to increase in docosahexaenoic acid. These changes in 13C enrichment in brain fatty acids paralleled the developmental changes in brain fatty acid composition. We conclude that, in the neonatal rat brain, dietary 16- and 18-carbon polyunsaturates are not only elongated and desaturated but are also utilized for de novo synthesis of long-chain saturated and monounsaturated fatty acids and cholesterol.
DAGNELIE PC, BELL JD, WILLIAMS SCR, et al., 1994, EFFECT OF FISH-OIL ON CANCER CACHEXIA AND HOST LIVER-METABOLISM IN RATS WITH PROSTATE TUMORS, LIPIDS, Vol: 29, Pages: 195-203, ISSN: 0024-4201
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- Citations: 28
MENON DK, LOCKWOOD GG, PEDEN CJ, et al., 1993, IN-VIVO F-19 MAGNETIC-RESONANCE SPECTROSCOPY OF CEREBRAL HALOTHANE IN POSTOPERATIVE-PATIENTS - PRELIMINARY-RESULTS, MAGNETIC RESONANCE IN MEDICINE, Vol: 30, Pages: 680-684, ISSN: 0740-3194
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- Citations: 13
Bell JD, Jane Cox I, Sargentoni J, et al., 1993, A <sup>31</sup>P and <sup>1</sup>H-NMR investigation in vitro of normal and abnormal human liver, BBA - Molecular Basis of Disease, Vol: 1225, Pages: 71-77, ISSN: 0925-4439
Spectral changes in human hepatic tumours and possible systemic effects of tumour on host liver were assessed by 31P amnd 1H in vitro NMR spectroscopy. The 1H and 31P spectra from liver tumour biopsies showed significant elevation in phosphoethanolamine, phosphocholine, taurine, citrate, alanine, lactate and glycine, and significant reduction in GPE (glycerophosphoethanolamine), GPC (glycerophosphocholine), creatine and threonine compared to histologically normal tissue. 31P-NMR spectra obtained from histologically normal tissue within tumour-bearing livers showed significant elevation in phosphoethanolamine and phosphocholine compared to data from liver biopsies from nontumour-bearing patients (pancreatitis). These results suggest that alterations in membrane metabolism in host liver can be detected by 31P-NMR. © 1993.
BELL JD, COX IJ, SARGENTONI J, et al., 1993, A P-31 AND H-1-NMR INVESTIGATION IN-VITRO OF NORMAL AND ABNORMAL HUMAN LIVER, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 1225, Pages: 71-77, ISSN: 0006-3002
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- Citations: 90
BELL JD, SADLER PJ, 1993, NMR - A CLINICAL APPROACH, CHEMISTRY IN BRITAIN, Vol: 29, Pages: 597-600, ISSN: 0009-3106
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- Citations: 1
BRENNER RE, MUNRO PMG, WILLIAMS SCR, et al., 1993, THE PROTON NMR-SPECTRUM IN ACUTE EAE - THE SIGNIFICANCE OF THE CHANGE IN THE CHO-CR RATIO, MAGNETIC RESONANCE IN MEDICINE, Vol: 29, Pages: 737-745, ISSN: 0740-3194
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- Citations: 173
DAGNELIE PC, BELL JD, WILLIAMS SCR, et al., 1993, ALTERED PHOSPHORYLATION STATUS, PHOSPHOLIPID-METABOLISM AND GLUCONEOGENESIS IN THE HOST LIVER OF RATS WITH PROSTATE-CANCER - A P-31 MAGNETIC-RESONANCE SPECTROSCOPY STUDY, BRITISH JOURNAL OF CANCER, Vol: 67, Pages: 1303-1309, ISSN: 0007-0920
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- Citations: 15
BELL JD, KUBAL G, RADULOVIC S, et al., 1993, DETECTION OF ALUMINUM(III) BINDING TO CITRATE IN HUMAN BLOOD-PLASMA BY PROTON NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY, ANALYST, Vol: 118, Pages: 241-244, ISSN: 0003-2654
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- Citations: 36
Cunnane SC, Allman T, Bell J, et al., 1993, In vivo fatty acid analysis in humans and animals using carbon-13 nuclear magnetic resonance spectroscopy., Pages: 355-358
DAGNELIE PC, MENON DK, COX IJ, et al., 1992, EFFECT OF L-ALANINE INFUSION ON P-31 NUCLEAR-MAGNETIC-RESONANCE SPECTRA OF NORMAL HUMAN LIVER - TOWARDS BIOCHEMICAL PATHOLOGY INVIVO, CLINICAL SCIENCE, Vol: 83, Pages: 183-190, ISSN: 0143-5221
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- Citations: 32
COX IJ, MENON DK, SARGENTONI J, et al., 1992, P-31 MAGNETIC-RESONANCE SPECTROSCOPY OF THE HUMAN LIVER USING CHEMICAL-SHIFT IMAGING TECHNIQUES, JOURNAL OF HEPATOLOGY, Vol: 14, Pages: 265-275, ISSN: 0168-8278
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- Citations: 53
BELL JD, COX IJ, WILLIAMS SCR, et al., 1991, INVIVO DETECTION OF METABOLIC CHANGES IN A MOUSE MODEL OF SCRAPIE USING NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY, JOURNAL OF GENERAL VIROLOGY, Vol: 72, Pages: 2419-2423, ISSN: 0022-1317
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- Citations: 18
Bell JD, Cox IJ, Williams SC, et al., 1991, In vivo detection of metabolic changes in a mouse model of scrapie using nuclear magnetic resonance spectroscopy., J Gen Virol, Vol: 72 ( Pt 10), Pages: 2419-2423, ISSN: 0022-1317
In vivo proton nuclear magnetic resonance (NMR) spectroscopy studies of scrapie in a mouse model have shown the appearance of an abnormal peak in the brain early in the incubation period. This abnormal peak was detected weeks before the detection of a protease-resistant form of a membrane protein and vacuolar histopathology in vitro, and several months before clinical signs, and the signal increased in intensity as the disease progressed. In the chronic stage of the disease, a reduction in N-acetyl aspartate levels was observed using in vivo and in vitro proton NMR spectroscopy.
Bell JD, Evans RW, Kiang W, et al., 1991, Aluminium speciation: NMR studies of blood plasma, transferrin and citrate complexes, Journal of Inorganic Biochemistry, Vol: 43, Pages: 488-488, ISSN: 0162-0134
RAFTER JEM, BATES TE, BELL JD, et al., 1991, METABOLITES IN THE DEVELOPING RAT-LIVER - A PROTON NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPIC STUDY, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 1074, Pages: 263-269, ISSN: 0006-3002
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- Citations: 14
GADIAN DG, BATES TE, WILLIAMS SR, et al., 1991, APPROACHES TO EDITING, ASSIGNMENT AND INTERPRETATION OF PROTON SPECTRA, NMR IN BIOMEDICINE, Vol: 4, Pages: 85-89, ISSN: 0952-3480
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- Citations: 22
BELL JD, LEE JA, LEE HA, et al., 1991, NUCLEAR-MAGNETIC-RESONANCE STUDIES OF BLOOD-PLASMA AND URINE FROM SUBJECTS WITH CHRONIC-RENAL-FAILURE - IDENTIFICATION OF TRIMETHYLAMINE-N-OXIDE, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 1096, Pages: 101-107, ISSN: 0006-3002
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- Citations: 128
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