ProfessorJimmyBell

Thomas EL, Collins AL, McCarthy J, Fitzpatrick J, Durighel G, Goldstone AP, Bell JDet al., 2011, Estimation of abdominal fat compartments by bioelectrical impedance: the validity of the ViScan measurement system in comparison with MRI (vol 64, pg 525, 2010), EUROPEAN JOURNAL OF CLINICAL NUTRITION, Vol: 65, Pages: 284-284, ISSN: 0954-3007

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• Citations: 1

Kenny GD, Kamaly N, Kalber TL, Brody LP, Sahuri M, Shamsaei E, Miller AD, Bell JDet al., 2011, Novel multifunctional nanoparticle mediates siRNA tumour delivery, visualisation and therapeutic tumour reduction <i>in vivo</i>, JOURNAL OF CONTROLLED RELEASE, Vol: 149, Pages: 111-116, ISSN: 0168-3659

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• Citations: 76

Modi N, Bell JD, 2011, Human Milk Fortifier with High Protein and Long Chain Polyunsaturated fatty acids for Improving Body Tissue Distribution

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Surman AJ, Bonnet CS, Lowe MP, Kenny GD, Bell JD, Tóth E, Vilar Ret al., 2011, A pyrophosphate-responsive gadolinium(III) MRI contrast agent., Chemistry, Vol: 17, Pages: 223-230

This study shows that the relaxivity and optical properties of functionalised lanthanide-DTPA-bis-amide complexes (lanthanide=Gd(3+) and Eu(3+) , DTPA=diethylene triamine pentaacetic acid) can be successfully modulated by addition of specific anions, without direct Ln(3+) /anion coordination. Zinc(II)-dipicolylamine moieties, which are known to bind strongly to phosphates, were introduced in the amide "arms" of these ligands, and the interaction of the resulting Gd-Zn(2) complexes with a range of anions was screened by using indicator displacement assays (IDAs). Considerable selectivity for polyphosphorylated species (such as pyrophosphate and adenosine-5'-triphosphate (ATP)) over a range of other anions (including monophosphorylated anions) was apparent. In addition, we show that pyrophosphate modulates the relaxivity of the gadolinium(III) complex, this modulation being sufficiently large to be observed in imaging experiments. To establish the binding mode of the pyrophosphate and gain insight into the origin of the relaxometric modulation, a series of studies including UV/Vis and emission spectroscopy, luminescence lifetime measurements in H(2) O and D(2) O, (17) O and (31) P NMR spectroscopy and nuclear magnetic resonance dispersion (NMRD) studies were carried out.

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Surman AJ, Kenny GD, Kumar DK, Bell JD, Casey DR, Vilar Ret al., 2011, Targeting of anionic membrane species by lanthanide(iii) complexes: towards improved MRI contrast agents for apoptosis, Chemical Communications, ISSN: 1359-7345

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Surman AJ, Bonnet CS, Lowe MP, Kenny GD, Bell JD, Toth E, Vilar Ret al., 2011, A Pyrophosphate-Responsive Gadolinium(III) MRI Contrast Agent, Chemistry - A European Journal, Vol: 17, Pages: 223-230, ISSN: 0947-6539

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Nunn AV, Guy GW, Brodie JS, Bell JDet al., 2010, Inflammatory modulation of exercise salience: using hormesis to return to a healthy lifestyle, NUTRITION & METABOLISM, Vol: 7

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• Citations: 21

Murgasova D, Logan K, Hyde MJ, Santhakumaran S, Thomas EL, Bell J, Modi Net al., 2010, IMPACT OF MATERNAL BODY MASS INDEX ON OFFSPRING LIVER LIPID DEPENDS ON MODE OF DELIVERY, PEDIATRIC RESEARCH, Vol: 68, Pages: 30-30, ISSN: 0031-3998

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So PW, Kalber T, Taylor-Robinson SD, Bell JDet al., 2010, The Application of Magnetic Resonance Imaging and Spectroscopy to Gene Therapy, Essential Whole Animal Imaging Methods

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Goldstone AP, de Hernandez CGP, Scholtz S, Durighel G, Ashby DR, Beckmann CF, Frost GS, Bloom SR, Bell JDet al., 2010, Ghrelin Mimics Fasting in Preferentially Increasing Reward Responses to High-Calorie Foods, 28th Annual Scientific Meeting of the Obesity, Publisher: NATURE PUBLISHING GROUP, Pages: S47-S48, ISSN: 1930-7381

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Lee L-W, So P-W, Price AN, Parkinson JRC, Larkman DJ, Halliday J, Poucher SM, Pugh JAT, Cox AG, McLeod CW, Bell JDet al., 2010, Manganese enhancement in non-CNS organs, NMR IN BIOMEDICINE, Vol: 23, Pages: 931-938, ISSN: 0952-3480

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• Citations: 8

Kalber TL, Kamaly N, So PW, Pugh JA, Bunch J, McLeod CW, Jorgensen MR, Miller AD, Bell JDet al., 2010, A Low Molecular Weight Folate Receptor Targeted Contrast Agent for Magnetic Resonance Tumor Imaging, Mol Imaging Biol

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Nunn AVW, Guy GW, Bell JD, 2010, Endocannabinoids, FOXO and the metabolic syndrome: Redox, function and tipping point - The view from two systems, IMMUNOBIOLOGY, Vol: 215, Pages: 617-628, ISSN: 0171-2985

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• Citations: 12

Watson RA, Pride NB, Thomas EL, Fitzpatrick J, Durighel G, McCarthy J, Morin SX, Ind PW, Bell JDet al., 2010, Reduction of total lung capacity in obese men: comparison of total intrathoracic and gas volumes, JOURNAL OF APPLIED PHYSIOLOGY, Vol: 108, Pages: 1605-1612, ISSN: 8750-7587

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• Citations: 59

Goldstone AP, de Hernandez CGP, Scholtz S, Durighel G, Deliran SS, Wong T, Ashby D, Frost G, Bloom SR, Bell JDet al., 2010, Ghrelin Mimics Fasting in Biasing Food Appeal towards High-Calorie Foods, 92nd Meeting and Expo of the Endocrine Society (ENDO 2010), Publisher: ENDOCRINE SOC, Pages: S2537-S2537, ISSN: 0163-769X

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Zeeni N, Nadkarni N, Bell JD, Even PC, Fromentin G, Tome D, Darcel Net al., 2010, Peripherally injected cholecystokinin-induced neuronal activation is modified by dietary composition in mice, NEUROIMAGE, Vol: 50, Pages: 1560-1565, ISSN: 1053-8119

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• Citations: 13

Kuo Y-T, So P-W, Parkinson JR, Yu WS, Hankir M, Herlihy AH, Goldstone AP, Frost GS, Wasserfall C, Bell JDet al., 2010, The combined effects on neuronal activation and blood-brain barrier permeability of time and n-3 polyunsaturated fatty acids in mice, as measured <i>in vivo</i> using MEMRI, NEUROIMAGE, Vol: 50, Pages: 1384-1391, ISSN: 1053-8119

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• Citations: 16

Thomas EL, Collins AL, McCarthy J, Fitzpatrick J, Durighel G, Goldstone AP, Bell JDet al., 2010, Estimation of abdominal fat compartments by bioelectrical impedance: the validity of the ViScan measurement system in comparison with MRI, EUROPEAN JOURNAL OF CLINICAL NUTRITION, Vol: 64, Pages: 525-533, ISSN: 0954-3007

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• Citations: 53

Kamaly N, Miller AD, Bell JD, 2010, Chemistry of Tumour Targeted T(1) Based MRI Contrast Agents., Current Topics in Medicinal Chemistry, ISSN: 1873-4294

For effective tumour imaging by magnetic resonance imaging (MRI) there is a clear need to develop organ, tissue and cell specific contrast agents that can selectively bind to tumour biomarkers. The versatility of a range of bioconjugation techniques and facile coupling chemistries has facilitated the synthesis of MRI contrast agents bearing tumour targeting moieties that comprise small molecule affinity ligands, peptides, antibodies and even proteins. The aim of this review is to describe the development and implementation of tumour targeted T(1) MRI contrast agents, with an emphasis on the chemistry used to modify pre-existing clinical MRI contrast agents for targeted tumour imaging.

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Johnston KL, Thomas EL, Bell JD, Frost GS, Robertson MDet al., 2010, Resistant starch improves insulin sensitivity in metabolic syndrome, DIABETIC MEDICINE, Vol: 27, Pages: 391-397, ISSN: 0742-3071

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• Citations: 187

Mehta SR, Thomas EL, Patel N, Crofton ME, McCarthy J, Eliahoo J, Morin SX, Fitzpatrick J, Durighel G, Goldstone AP, Johnston DG, Bell JD, Taylor-Robinson SDet al., 2010, Proton magnetic resonance spectroscopy and ultrasound for hepatic fat quantification, HEPATOLOGY RESEARCH, Vol: 40, Pages: 399-406, ISSN: 1386-6346

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• Citations: 26

So P-W, Kalber T, Hunt D, Farquharson M, Al-Ebraheem A, Parkes HG, Simon R, Bell JDet al., 2010, Efficient and Rapid Labeling of Transplanted Cell Populations With Superparamagnetic Iron Oxide Nanoparticles Using Cell Surface Chemical Biotinylation for In Vivo Monitoring by MRI, CELL TRANSPLANTATION, Vol: 19, Pages: 419-429, ISSN: 0963-6897

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• Citations: 24

Morin SHX, Cobbold JFL, Lim AKP, Eliahoo J, Thomas EL, Mehta SR, Durighel G, Fitzpatrick J, Bell JD, Taylor-Robinson SDet al., 2009, Incidental findings in healthy control research subjects using whole-body MRI, EUROPEAN JOURNAL OF RADIOLOGY, Vol: 72, Pages: 529-533, ISSN: 0720-048X

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• Citations: 57

O'Donovan G, Thomas EL, McCarthy JP, Fitzpatrick J, Durighel G, Mehta S, Morin SX, Goldstone AP, Bell JDet al., 2009, Fat distribution in men of different waist girth, fitness level and exercise habit, INTERNATIONAL JOURNAL OF OBESITY, Vol: 33, Pages: 1356-1362, ISSN: 0307-0565

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• Citations: 30

Kamaly N, Pugh JA, Kalber TL, Bunch J, Miller AD, McLeod CW, Bell JDet al., 2009, Imaging of Gadolinium Spatial Distribution in Tumor Tissue by Laser Ablation Inductively Coupled Plasma Mass Spectrometry., Mol. Imaging. Biol., ISSN: 1860-2002

PURPOSE: Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) was utilized in postmortem imaging of gadolinium (Gd) spatial distribution in a mouse tumor model postadministration of PEGylated Gd liposomal nanoparticles. PROCEDURES: PEGylated liposomal nanoparticles were formulated using a paramagnetic lipid incorporating Gd, in addition to a fluorescent lipid, and injected intravenously into Balb/C nude mice bearing IGROV-1 tumors. At postinjection (2 h), the tumors and selective organs were imaged by magnetic resonance imaging (MRI) and, after excision, by histology and LA-ICP-MS. RESULTS: The presence of Gd within tumor tissue was confirmed by LA-ICP-MS and when correlated to histology was found to be prevalent in regions of higher vascularity. The presence of Gd in the kidneys was also confirmed. CONCLUSIONS: We have demonstrated, in a novel manner, the use of LA-ICP-MS for the spatial detection of Gd in tumor tissue. LA-ICP-MS is valuable in providing spatio-specific information of MRI contrast agents and more importantly Gd in tumor tissue.

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Al-Qassab H, Smith MA, Irvine EE, Guillermet-Guibert J, Claret M, Choudhury AI, Selman C, Piipari K, Clements M, Lingard S, Chandarana K, Bell JD, Barsh GS, Smith AJH, Batterham RL, Ashford MLJ, Vanhaesebroeck B, Withers DJet al., 2009, Dominant Role of the p110β Isoform of PI3K over p110α in Energy Homeostasis Regulation by POMC and AgRP Neurons, CELL METABOLISM, Vol: 10, Pages: 343-354, ISSN: 1550-4131

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• Citations: 132

Goldstone AP, de Hernandez CGP, Bell JD, Beaver JD, Croese C, Muhammed K, Bell G, Giuliana D, Hughes E, Waldman AD, Gary Fet al., 2009, Fasting Biases Brain Reward Systems Towards High-Calorie Foods, 27th Annual Scientific Meeting of the Obesity-Society, Publisher: NATURE PUBLISHING GROUP, Pages: S84-S84, ISSN: 1930-7381

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So PW, Bhakoo KK, Cox IJ, Taylor-Robinson SD, Bell JDet al., 2009, The application of magnetic resonance imaging and spectroscopy to gene therapy., Essential Bioimaging Methods, Editors: Conn, Burlington, Publisher: Academic Press, Pages: 373-397, ISBN: 9780123750433

Part of the Reliable Lab Solution series, this volume provides clear advice and explicitprotocols, providing updates to classic, tried-and-true methods and an ...

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Vasu V, Thomas EL, Durighel G, Uthaya S, Bell JD, Modi Net al., 2009, LEAN BODY MASS IS REDUCED IN PRETERM INFANTS AT TERM AGE, ACTA PAEDIATRICA, Vol: 98, Pages: 63-63, ISSN: 0803-5253

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• Citations: 2

, 2009, Abstracts of the 50th Annual Meeting of the European Society for Paediatric Research. October 9-12, 2009. Hamburg, Germany., Acta Paediatr, Vol: 98, Pages: 1-278

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