Publications
346 results found
Oliver M, Ahmad A, Kamaly N, et al., 2006, MAGfect: a novel liposome formulation for MRI labelling and visualization of cells, Org. Biomol. Chem., Vol: 4, Pages: 3489-3497, ISSN: 1477-0520
Cellular entry of imaging probes, such as contrast agents for magnetic resonance imaging (MRI), is a key requirement for many molecular imaging studies, particularly imaging intracellular events and cell tracking. Here, we describe the successful development and in vitro analysis of MAGfect, a novel liposome formulation containing a lipidic gadolinium contrast agent for MRI, Gd-DOTA-Chol 1, designed to enter and label cells. Liposome formulation and cell incubation time were optimised for maximum cellular uptake of the imaging probe in a variety of cell lines. MRI analysis of cells incubated with MAGfect showed them to be highly MRI active. This formulation was examined further for cytotoxicity, cell viability and mechanism of cell labelling. One of the key advantages of using MAGfect as a labelling vehicle arises from its potential for additional functions, such as concomitant drug or gene delivery and fluorescent labelling. The gadolinium liposome was found to be an effective vehicle for transport of plasmid DNA (pDNA) into cells and expression levels were comparable to the commercial transfection agent Trojene(TM).
So PW, Bell JD, 2006, The application of in vivo MRI and MRS in phenomic studies of murine models of disease, Modern Magnetic Resonance, Editors: Webb, UK, Publisher: Springer
Young IR, Bell JD, Hajnal JV, et al., 2005, Evaluation of the stability of the proton chemical shifts of some metabolites other than water during thermal cycling of normal human muscle tissue, JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol: 8, Pages: 1114-1118, ISSN: 1053-1807
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- Citations: 6
DAGNELIE PC, BELL JD, COX IJ, et al., 2005, EFFECTS OF FISH OIL ON PHOSPHOLIPID-METABOLISM IN HUMAN AND RAT-LIVER STUDIED BY P-31 NMR-SPECTROSCOPY INVIVO AND INVITRO, NMR IN BIOMEDICINE, Vol: 6, Pages: 157-162, ISSN: 0952-3480
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- Citations: 8
COX IJ, BELL JD, PEDEN CJ, et al., 2005, INVIVO AND INVITRO P-31 MAGNETIC-RESONANCE SPECTROSCOPY OF FOCAL HEPATIC MALIGNANCIES, NMR IN BIOMEDICINE, Vol: 5, Pages: 114-120, ISSN: 0952-3480
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- Citations: 41
Chung YL, Rider LG, Bell JD, et al., 2005, Muscle metabolites, detected in urine by proton spectroscopy, correlate with disease damage in juvenile idiopathic inflammatory myopathies, ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH, Vol: 53, Pages: 565-570, ISSN: 0004-3591
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- Citations: 22
Uthaya S, Thomas EL, Hamilton G, et al., 2005, Preterm infants at term show increased intrahepatocellular lipid content on proton magnetic resonance spectroscopy, 46th Annual Meeting of the European-Society-for-Paediatric-Research, Publisher: INT PEDIATRIC RESEARCH FOUNDATION, INC, Pages: 420-420, ISSN: 0031-3998
So PW, Hotee S, Herlihy AH, et al., 2005, Generic method for imaging transgene expression, MAGNETIC RESONANCE IN MEDICINE, Vol: 54, Pages: 218-221, ISSN: 0740-3194
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- Citations: 14
So PW, Herlihy AH, Bell JD, 2005, Adiposity induced by adenovirus 5 inoculation, INTERNATIONAL JOURNAL OF OBESITY, Vol: 29, Pages: 603-606, ISSN: 0307-0565
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- Citations: 56
Ostberg JE, Thomas EL, Hamilton G, et al., 2005, Excess visceral and hepatic adipose tissue in Turner syndrome determined by magnetic resonance imaging: Estrogen deficiency associated with hepatic adipose content, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 90, Pages: 2631-2635, ISSN: 0021-972X
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- Citations: 67
Kuo YT, Herlihy AH, So PW, et al., 2005, In vivo measurements of T1 relaxation times in mouse brain associated with different modes of systemic administration of manganese chloride, JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol: 21, Pages: 334-339, ISSN: 1053-1807
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- Citations: 68
Choudhury AI, Heffron H, Smith MA, et al., 2005, The role of insulin receptor substrate 2 in hypothalamic and β cell function, JOURNAL OF CLINICAL INVESTIGATION, Vol: 115, Pages: 940-950, ISSN: 0021-9738
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- Citations: 200
Goff LM, Bell JD, So PW, et al., 2005, Veganism and its relationship with insulin resistance and intramyocellular lipid, EUROPEAN JOURNAL OF CLINICAL NUTRITION, Vol: 59, Pages: 291-298, ISSN: 0954-3007
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- Citations: 50
Holdcroft A, Hall L, Hamilton G, et al., 2005, Phosphorus-31 brain MR spectroscopy in women during and after pregnancy compared with nonpregnant control subjects, AMERICAN JOURNAL OF NEURORADIOLOGY, Vol: 26, Pages: 352-356, ISSN: 0195-6108
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- Citations: 12
Uthaya S, Thomas EL, Hamilton G, et al., 2005, Altered adiposity after extremely preterm birth, PEDIATRIC RESEARCH, Vol: 57, Pages: 211-215, ISSN: 0031-3998
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- Citations: 188
Thomas EL, Hamilton G, Patel N, et al., 2005, Hepatic triglyceride content and its relation to body adiposity:: a magnetic resonance imaging and proton magnetic resonance spectroscopy study, GUT, Vol: 54, Pages: 122-127, ISSN: 0017-5749
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- Citations: 256
Robson MD, Gatehouse PD, So PW, et al., 2004, Contrast enhancement of short T2 tissues using ultrashort TE (UTE) pulse sequences, CLINICAL RADIOLOGY, Vol: 59, Pages: 720-726, ISSN: 0009-9260
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- Citations: 35
, 2004, 40th EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004., Diabetologia, Vol: 47, Pages: A1-A464
Goldstone AP, Thomas EL, Brynes AE, et al., 2004, Elevated fasting plasma ghrelin in Prader-Willi syndrome adults is not solely explained by their reduced visceral adiposity and insulin resistance, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 89, Pages: 1718-1726, ISSN: 0021-972X
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- Citations: 83
Savage DB, Soos MA, Powlson A, et al., 2004, Familial partial lipodystrophy associated with compound heterozygosity for novel mutations in the <i>LMNA</i> gene, DIABETOLOGIA, Vol: 47, Pages: 753-756, ISSN: 0012-186X
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- Citations: 37
Harrington TAM, Thomas EL, Frost G, et al., 2004, Distribution of adipose tissue in the newborn, PEDIATRIC RESEARCH, Vol: 55, Pages: 437-441, ISSN: 0031-3998
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- Citations: 97
Uthaya S, Bell J, Modi N, 2004, Adipose tissue magnetic resonance imaging in the newborn, HORMONE RESEARCH, Vol: 62, Pages: 143-148, ISSN: 0301-0163
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- Citations: 13
Leonardsson G, Steel JH, Christian M, et al., 2004, Nuclear receptor corepressor RIP140 regulates fat accumulation, Proceedings of the National Academy of Sciences of the United States of America, Vol: 101, Pages: 8437-8442, ISSN: 0027-8424
Bhakoo KK, Bell JD, Cox IJ, et al., 2004, The application of magnetic resonance imaging and spectroscopy to gene therapy, IMAGING IN BIOLOGICAL RESEARCH, PT B, Vol: 386, Pages: 303-313, ISSN: 0076-6879
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- Citations: 4
Chung YL, Barr J, Bhakoo K, et al., 2003, <i>N</i>-acetyl aspartate estimation:: a potential method for determining neuronal loss in the transmissible spongiform encephalopathies, NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol: 29, Pages: 445-450, ISSN: 0305-1846
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- Citations: 7
Savage DB, Tan GD, Acerini CL, et al., 2003, Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-γ, DIABETES, Vol: 52, Pages: 910-917, ISSN: 0012-1797
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- Citations: 331
Goff LM, Frost GS, Hamilton G, et al., 2003, Carbohydrate-induced manipulation of insulin sensitivity independently of intramyocellular lipids, BRITISH JOURNAL OF NUTRITION, Vol: 89, Pages: 365-374, ISSN: 0007-1145
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- Citations: 21
Chung YL, Wassif WS, Bell JD, et al., 2003, Urinary levels of creatine and other metabolites in the assessment of polymyositis and dermatomyositis, RHEUMATOLOGY, Vol: 42, Pages: 298-303, ISSN: 1462-0324
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- Citations: 22
Thomas EL, Bell JD, 2003, Influence of undersampling on magnetic resonance imaging measurements of intra-abdominal adipose tissue, INTERNATIONAL JOURNAL OF OBESITY, Vol: 27, Pages: 211-218, ISSN: 0307-0565
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- Citations: 89
Lim AKP, Hamilton G, Patel N, et al., 2003, <SUP>1</SUP>H MR spectroscopy in the evaluation of the severity of chronic liver disease, RADIOLOGY, Vol: 226, Pages: 288-289, ISSN: 0033-8419
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- Citations: 9
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