Imperial College London
Alternate

ProfessorJimmyBell

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 3506 4608jimmy.bell Website

 
 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ji:2019:10.2337/db18-0708,
author = {Ji, Y and Yiorkas, AM and Frau, F and Mook-Kanamori, D and Staiger, H and Thomas, EL and Atabaki-Pasdar, N and Campbell, A and Tyrrell, J and Jones, SE and Beaumont, RN and Wood, AR and Tuke, MA and Ruth, KS and Mahajan, A and Murray, A and Freathy, RM and Weedon, MN and Hattersley, AT and Hayward, C and Machann, J and Haering, H-U and Franks, P and de, Mutsert R and Pearson, E and Stefan, N and Frayling, TM and Allebrandt, KV and Bell, JD and Blakemore, AI and Yaghootkar, H},
doi = {10.2337/db18-0708},
journal = {Diabetes},
pages = {207--219},
title = {Genome-wide and abdominal MRI data provide evidence that a genetically determined favorable adiposity phenotype is characterized by lower ectopic liver fat and lower risk of type 2 diabetes, heart disease, and hypertension},
url = {http://dx.doi.org/10.2337/db18-0708},
volume = {68},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Recent genetic studies have identified alleles associated with opposite effects on adiposity and risk of type 2 diabetes. We aimed to identify more of these variants and test the hypothesis that such favorable adiposity alleles are associated with higher subcutaneous fat and lower ectopic fat. We combined MRI data with genome-wide association studies of body fat percentage (%) and metabolic traits. We report 14 alleles, including 7 newly characterized alleles, associated with higher adiposity but a favorable metabolic profile. Consistent with previous studies, individuals carrying more favorable adiposity alleles had higher body fat % and higher BMI but lower risk of type 2 diabetes, heart disease, and hypertension. These individuals also had higher subcutaneous fat but lower liver fat and a lower visceral-to-subcutaneous adipose tissue ratio. Individual alleles associated with higher body fat % but lower liver fat and lower risk of type 2 diabetes included those in PPARG, GRB14, and IRS1, whereas the allele in ANKRD55 was paradoxically associated with higher visceral fat but lower risk of type 2 diabetes. Most identified favorable adiposity alleles are associated with higher subcutaneous and lower liver fat, a mechanism consistent with the beneficial effects of storing excess triglycerides in metabolically low-risk depots.
AU  - Ji,Y
AU  - Yiorkas,AM
AU  - Frau,F
AU  - Mook-Kanamori,D
AU  - Staiger,H
AU  - Thomas,EL
AU  - Atabaki-Pasdar,N
AU  - Campbell,A
AU  - Tyrrell,J
AU  - Jones,SE
AU  - Beaumont,RN
AU  - Wood,AR
AU  - Tuke,MA
AU  - Ruth,KS
AU  - Mahajan,A
AU  - Murray,A
AU  - Freathy,RM
AU  - Weedon,MN
AU  - Hattersley,AT
AU  - Hayward,C
AU  - Machann,J
AU  - Haering,H-U
AU  - Franks,P
AU  - de,Mutsert R
AU  - Pearson,E
AU  - Stefan,N
AU  - Frayling,TM
AU  - Allebrandt,KV
AU  - Bell,JD
AU  - Blakemore,AI
AU  - Yaghootkar,H
DO  - 10.2337/db18-0708
EP  - 219
PY  - 2019///
SN  - 0012-1797
SP  - 207
TI  - Genome-wide and abdominal MRI data provide evidence that a genetically determined favorable adiposity phenotype is characterized by lower ectopic liver fat and lower risk of type 2 diabetes, heart disease, and hypertension
T2  - Diabetes
UR  - http://dx.doi.org/10.2337/db18-0708
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000453906300020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://diabetes.diabetesjournals.org/content/68/1/207
UR  - http://hdl.handle.net/10044/1/72183
VL  - 68
ER  -
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