Imperial College London
Alternate

ProfessorJimmyBell

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 3506 4608jimmy.bell Website

 
 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wilman:2017:10.1371/journal.pone.0172921,
author = {Wilman, HR and Kelly, M and Garratt, S and Matthews, PM and Milanesi, M and Herlihy, A and Gyngell, M and Neubauer, S and Bell, JD and Banerjee, R and Thomas, EL},
doi = {10.1371/journal.pone.0172921},
journal = {PLOS ONE},
title = {Characterisation of liver fat in the UK Biobank cohort},
url = {http://dx.doi.org/10.1371/journal.pone.0172921},
volume = {12},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Non-alcoholicfattyliverdiseaseandtheriskof progressionto steatohepatitis,cirrhosisandhepatocellularcarcinomahavebeenidentifiedasmajorpublichealthconcerns.Wehavedemonstratedthefeasibilityandpotentialvalueof measuringliverfatcontentbymagneticresonanceimaging(MRI)in a largepopulationin thisstudyof 4,949participants(aged45–73years)in theUKBiobankimagingenhancement. Despiterequirementsforonlya single( 3min)scanof eachsubject,liverfatwasableto bemeasuredastheMRIprotondensityfatfraction(PDFF)withanoverallsuccessrateof 96.4%.Theoverallhepaticfatdistributionwascentredbetween1–2%,andwashighlyskewedtowardshigherfatcontent.ThemeanPDFFwas3.91%,andmedian2.11%.Analysisof PDFFin conjunctionwithotherdatafieldsavailablefromtheUKBiobankResourceshowedassociationsof increasedliverfatwithgreaterage,BMI,weightgain,highbloodpressureandType2 diabetes.SubjectswithBMIlessthan25kg/m2hada lowrisk(5%)of highliverfat(PDFF>5.5%),whereasin thehigherBMIpopulation(>30kg/m2) theprevalenceof highliverfatwasapproximately1 in 3. Thesedatasuggestthatpopulationscreeningto identifypeoplewithhighPDFFis possibleandcouldbecosteffective.MRIbasedPDFFis aneffectivemethodforthis.Finally,althoughcrosssectional,thisstudysuggeststheutilityof thePDFFmeasurement withinUKBiobank,particularlyforapplicationsto elucidatingriskfactorsthroughassociationswithprospec-tivelyacquireddataonclinicaloutcomesof liverdiseases,includingnon-alcoholicfattyliverdisease.
AU  - Wilman,HR
AU  - Kelly,M
AU  - Garratt,S
AU  - Matthews,PM
AU  - Milanesi,M
AU  - Herlihy,A
AU  - Gyngell,M
AU  - Neubauer,S
AU  - Bell,JD
AU  - Banerjee,R
AU  - Thomas,EL
DO  - 10.1371/journal.pone.0172921
PY  - 2017///
SN  - 1932-6203
TI  - Characterisation of liver fat in the UK Biobank cohort
T2  - PLOS ONE
UR  - http://dx.doi.org/10.1371/journal.pone.0172921
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000395934400050&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/45831
VL  - 12
ER  -
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