Imperial College London
Alternate

ProfessorJimmyBell

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 3506 4608jimmy.bell Website

 
 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Henley:2017:10.1371/journal.pone.0170917,
author = {Henley, AB and Yang, L and Chuang, K-L and Sahuri-Arisoylu, M and Wu, L-H and Bligh, SWA and Bell, JD},
doi = {10.1371/journal.pone.0170917},
journal = {PLoS ONE},
title = {Withania somnifera Root Extract Enhances Chemotherapy through ‘Priming’},
url = {http://dx.doi.org/10.1371/journal.pone.0170917},
volume = {12},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Withania somnifera extracts are known for their anti-cancerous, anti-inflammatory and antioxidativeproperties. One of their mechanisms of actions is to modulate mitochondrial functionthrough increasing oxidative stress. Recently ‘priming’ has been suggested as apotential mechanism for enhancing cancer cell death. In this study we demonstrate that‘priming’, in HT-29 colon cells, with W. somnifera root extract increased the potency of thechemotherapeutic agent cisplatin. We have also showed the W. somnifera root extractenhanced mitochondrial dysfunction and that the underlying mechanism of ‘priming’ wasselectively through increased ROS. Moreover, we showed that this effect was not seen innon-cancerous cells.
AU  - Henley,AB
AU  - Yang,L
AU  - Chuang,K-L
AU  - Sahuri-Arisoylu,M
AU  - Wu,L-H
AU  - Bligh,SWA
AU  - Bell,JD
DO  - 10.1371/journal.pone.0170917
PY  - 2017///
SN  - 1932-6203
TI  - Withania somnifera Root Extract Enhances Chemotherapy through ‘Priming’
T2  - PLoS ONE
UR  - http://dx.doi.org/10.1371/journal.pone.0170917
UR  - http://hdl.handle.net/10044/1/52999
VL  - 12
ER  -
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