Imperial College London
Alternate

ProfessorJimmyBell

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 3506 4608jimmy.bell Website

 
 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Brody:2017:10.2147/IJN.S135968,
author = {Brody, LP and Sahuri-Arisoylu, M and Parkinson, JR and Parkes, HG and So, PW and Hajji, N and Thomas, EL and Frost, GS and Miller, AD and Bell, JD},
doi = {10.2147/IJN.S135968},
journal = {International Journal of Nanomedicine},
pages = {6677--6685},
title = {Cationic lipid-based nanoparticles mediate functional delivery of acetate to tumor cells in vivo leading to significant anticancer effects},
url = {http://dx.doi.org/10.2147/IJN.S135968},
volume = {12},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Metabolic reengineering using nanoparticle delivery represents an innovative therapeutic approach to normalizing the deregulation of cellular metabolism underlying many diseases, including cancer. Here, we demonstrated a unique and novel application to the treatment of malignancy using a short-chain fatty acid (SCFA)-encapsulated lipid-based delivery system – liposome-encapsulated acetate nanoparticles for cancer applications (LITA-CAN). We assessed chronic in vivo administration of our nanoparticle in three separate murine models of colorectal cancer. We demonstrated a substantial reduction in tumor growth in the xenograft model of colorectal cancer cell lines HT-29, HCT-116 p53+/+ and HCT-116 p53-/-. Nanoparticle-induced reductions in histone deacetylase gene expression indicated a potential mechanism for these anti-proliferative effects. Together, these results indicated that LITA-CAN could be used as an effective direct or adjunct therapy to treat malignant transformation in vivo.
AU  - Brody,LP
AU  - Sahuri-Arisoylu,M
AU  - Parkinson,JR
AU  - Parkes,HG
AU  - So,PW
AU  - Hajji,N
AU  - Thomas,EL
AU  - Frost,GS
AU  - Miller,AD
AU  - Bell,JD
DO  - 10.2147/IJN.S135968
EP  - 6685
PY  - 2017///
SN  - 1176-9114
SP  - 6677
TI  - Cationic lipid-based nanoparticles mediate functional delivery of acetate to tumor cells in vivo leading to significant anticancer effects
T2  - International Journal of Nanomedicine
UR  - http://dx.doi.org/10.2147/IJN.S135968
UR  - http://hdl.handle.net/10044/1/54014
VL  - 12
ER  -
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