Imperial College London
Alternate

Joanne P. Webster

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

joanne.webster Website

 
 
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Location

 

Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Easton:2020:10.7554/eLife.61562,
author = {Easton, A and Gao, S and Lawton, SP and Bennuru, S and Khan, A and Dahlstrom, E and Oliveira, RG and Kepha, S and Porcella, SF and Webster, J and Anderson, R and Grigg, ME and Davis, RE and Wang, J and Nutman, TB},
doi = {10.7554/eLife.61562},
journal = {eLife},
title = {Molecular evidence of hybridization between pig and human Ascaris indicates an interbred species complex infecting humans},
url = {http://dx.doi.org/10.7554/eLife.61562},
volume = {9},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Human ascariasis is a major neglected tropical disease caused by the nematode Ascaris lumbricoides. We report a 296 megabase (Mb) reference-quality genome comprised of 17,902 protein-coding genes derived from a single, representative Ascaris worm. An additional 68 worms were collected from 60 human hosts in Kenyan villages where pig husbandry is rare. Notably, the majority of these worms (63/68) possessed mitochondrial genomes that clustered closer to the pig parasite Ascaris suum than to A. lumbricoides. Comparative phylogenomic analyses identified over 11 million nuclear-encoded SNPs but just two distinct genetic types that had recombined across the genomes analyzed. The nuclear genomes had extensive heterozygosity, and all samples existed as genetic mosaics with either A. suum-like or A. lumbricoides-like inheritance patterns supporting a highly interbred Ascaris species genetic complex. As no barriers appear to exist for anthroponotic transmission of these 'hybrid' worms, a one-health approach to control the spread of human ascariasis will be necessary.
AU  - Easton,A
AU  - Gao,S
AU  - Lawton,SP
AU  - Bennuru,S
AU  - Khan,A
AU  - Dahlstrom,E
AU  - Oliveira,RG
AU  - Kepha,S
AU  - Porcella,SF
AU  - Webster,J
AU  - Anderson,R
AU  - Grigg,ME
AU  - Davis,RE
AU  - Wang,J
AU  - Nutman,TB
DO  - 10.7554/eLife.61562
PY  - 2020///
SN  - 2050-084X
TI  - Molecular evidence of hybridization between pig and human Ascaris indicates an interbred species complex infecting humans
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.61562
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33155980
UR  - http://hdl.handle.net/10044/1/84891
VL  - 9
ER  -
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