Imperial College London
Alternate

Joanne P. Webster

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
//

Contact

 

joanne.webster Website

 
 
//

Location

 

Medical SchoolSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Liang:2022:10.1371/journal.pntd.0010389,
author = {Liang, S and Ponpetch, K and Zhou, Y-B and Guo, J and Erko, B and Stothard, JR and Murad, MH and Zhou, X-N and Satrija, F and Webster, JP and Remais, JV and Utzinger, J and Garba, A},
doi = {10.1371/journal.pntd.0010389},
journal = {PLoS Negl Trop Dis},
title = {Diagnosis of Schistosoma infection in non-human animal hosts: A systematic review and meta-analysis.},
url = {http://dx.doi.org/10.1371/journal.pntd.0010389},
volume = {16},
year = {2022}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Reliable and field-applicable diagnosis of schistosome infections in non-human animals is important for surveillance, control, and verification of interruption of human schistosomiasis transmission. This study aimed to summarize uses of available diagnostic techniques through a systematic review and meta-analysis. METHODOLOGY AND PRINCIPAL FINDINGS: We systematically searched the literature and reports comparing two or more diagnostic tests in non-human animals for schistosome infection. Out of 4,909 articles and reports screened, 19 met our inclusion criteria, four of which were considered in the meta-analysis. A total of 14 techniques (parasitologic, immunologic, and molecular) and nine types of non-human animals were involved in the studies. Notably, four studies compared parasitologic tests (miracidium hatching test (MHT), Kato-Katz (KK), the Danish Bilharziasis Laboratory technique (DBL), and formalin-ethyl acetate sedimentation-digestion (FEA-SD)) with quantitative polymerase chain reaction (qPCR), and sensitivity estimates (using qPCR as the reference) were extracted and included in the meta-analyses, showing significant heterogeneity across studies and animal hosts. The pooled estimate of sensitivity was 0.21 (95% confidence interval (CI): 0.03-0.48) with FEA-SD showing highest sensitivity (0.89, 95% CI: 0.65-1.00). CONCLUSIONS/SIGNIFICANCE: Our findings suggest that the parasitologic technique FEA-SD and the molecular technique qPCR are the most promising techniques for schistosome diagnosis in non-human animal hosts. Future studies are needed for validation and standardization of the techniques for real-world field applications.
AU  - Liang,S
AU  - Ponpetch,K
AU  - Zhou,Y-B
AU  - Guo,J
AU  - Erko,B
AU  - Stothard,JR
AU  - Murad,MH
AU  - Zhou,X-N
AU  - Satrija,F
AU  - Webster,JP
AU  - Remais,JV
AU  - Utzinger,J
AU  - Garba,A
DO  - 10.1371/journal.pntd.0010389
PY  - 2022///
TI  - Diagnosis of Schistosoma infection in non-human animal hosts: A systematic review and meta-analysis.
T2  - PLoS Negl Trop Dis
UR  - http://dx.doi.org/10.1371/journal.pntd.0010389
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35522699
VL  - 16
ER  -
Download