Imperial College London
Alternate

Joanne P. Webster

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

joanne.webster Website

 
 
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Location

 

Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Platt:2021:10.1101/2021.10.25.465783,
author = {Platt, RN and Le, Clech W and Chevalier, FD and McDew-White, M and LoVerde, PT and de, Assis RR and Oliveira, G and Kinunghi, S and Djirmay, AG and Steinauer, ML and Gouvras, A and Rabone, M and Allan, F and Webster, BL and Webster, JP and Emery, A and Rollinson, D and Anderson, TJC},
doi = {10.1101/2021.10.25.465783},
title = {Genomic analysis of a parasite invasion: colonization of the Americas by the blood fluke, <i>Schistosoma mansoni</i>},
url = {http://dx.doi.org/10.1101/2021.10.25.465783},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p><jats:italic>Schistosoma mansoni,</jats:italic> a snail-vectored, blood fluke that infects humans, was introduced into the Americas from Africa during the Trans-Atlantic slave trade. As this parasite shows strong specificity to the snail intermediate host, we expected that adaptation to S. American <jats:italic>Biomphalaria</jats:italic> spp. snails would result in population bottlenecks and strong signatures of selection. We scored 475,081 single nucleotide variants (SNVs) in 143 <jats:italic>S. mansoni</jats:italic> from the Americas (Brazil, Guadeloupe, and Puerto Rico) and Africa (Cameroon, Niger, Senegal, Tanzania, and Uganda), and used these data to ask: (i) Was there a population bottleneck during colonization? (ii) Can we identify signatures of selection associated with colonization? And (iii) what were the source populations for colonizing parasites? We found a 2.4-2.9-fold reduction in diversity and much slower decay in linkage disequilibrium (LD) in parasites from East to West Africa. However, we observed similar nuclear diversity and LD in West Africa and Brazil, suggesting no strong bottlenecks and limited barriers to colonization. We identified five genome regions showing selection in the Americas, compared with three in West Africa and none in East Africa, which we speculate may reflect adaptation during colonization. Finally, we infer that unsampled African populations from central African regions between Benin and Angola, with contributions from Niger, are likely the major source(s) for Brazilian <jats:italic>S. mansoni</jats:italic>. The absence of a bottleneck suggests that this is a rare case of a serendipitous invasion, where <jats:italic>S. mansoni</jats:italic> parasites were preadapted to the Americas and were able to establish with relative ease.</jats:p>
AU  - Platt,RN
AU  - Le,Clech W
AU  - Chevalier,FD
AU  - McDew-White,M
AU  - LoVerde,PT
AU  - de,Assis RR
AU  - Oliveira,G
AU  - Kinunghi,S
AU  - Djirmay,AG
AU  - Steinauer,ML
AU  - Gouvras,A
AU  - Rabone,M
AU  - Allan,F
AU  - Webster,BL
AU  - Webster,JP
AU  - Emery,A
AU  - Rollinson,D
AU  - Anderson,TJC
DO  - 10.1101/2021.10.25.465783
PY  - 2021///
TI  - Genomic analysis of a parasite invasion: colonization of the Americas by the blood fluke, <i>Schistosoma mansoni</i>
UR  - http://dx.doi.org/10.1101/2021.10.25.465783
ER  -
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