Imperial College London
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DrJohannaRhodes

Faculty of Medicine, School of Public Health

Honorary Research Fellow
 
 
 
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Contact

 

johanna.rhodes

 
 
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Location

 

Desk 17Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Duong:2021:10.1111/1462-2920.15660,
author = {Duong, T-MN and Le, T-V and Tran, K-LH and Nguyen, P-T and Nguyen, B-PT and Nguyen, T-A and Nguyen, H-LP and Nguyen, B-NT and Fisher, MC and Rhodes, J and Marks, G and Fox, GJ and Chen, SC-A and Walsh, MG and Barrs, VR and Talbot, J and Halliday, CL and Sorrell, TC and Day, JN and Beardsley, J},
doi = {10.1111/1462-2920.15660},
journal = {Environmental Microbiology},
pages = {7632--7642},
title = {Azole-resistant Aspergillus fumigatus is highly prevalent in the environment of Vietnam, with marked variability by land use type},
url = {http://dx.doi.org/10.1111/1462-2920.15660},
volume = {23},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Azole-resistant environmental Aspergillus fumigatus presents a threat to public health but the extent of this threat in Southeast Asia is poorly described. We conducted environmental surveillance in the Mekong Delta region of Vietnam, collecting air and ground samples across key land-use types, and determined antifungal susceptibilities of Aspergillus section Fumigati (ASF) isolates and azole concentrations in soils. Of 119 ASF isolates, 55% were resistant (or non-wild type) to itraconazole, 65% to posaconazole and 50% to voriconazole. Azole resistance was more frequent in A. fumigatus sensu stricto isolates (95%) than other ASF species (32%). Resistant isolates and agricultural azole residues were overrepresented in samples from cultivated land. cyp51A gene sequence analysis showed 38/56 resistant A. fumigatus sensu stricto isolates carried known resistance mutations, with TR34/L98H most frequent (34/38).
AU  - Duong,T-MN
AU  - Le,T-V
AU  - Tran,K-LH
AU  - Nguyen,P-T
AU  - Nguyen,B-PT
AU  - Nguyen,T-A
AU  - Nguyen,H-LP
AU  - Nguyen,B-NT
AU  - Fisher,MC
AU  - Rhodes,J
AU  - Marks,G
AU  - Fox,GJ
AU  - Chen,SC-A
AU  - Walsh,MG
AU  - Barrs,VR
AU  - Talbot,J
AU  - Halliday,CL
AU  - Sorrell,TC
AU  - Day,JN
AU  - Beardsley,J
DO  - 10.1111/1462-2920.15660
EP  - 7642
PY  - 2021///
SN  - 1462-2912
SP  - 7632
TI  - Azole-resistant Aspergillus fumigatus is highly prevalent in the environment of Vietnam, with marked variability by land use type
T2  - Environmental Microbiology
UR  - http://dx.doi.org/10.1111/1462-2920.15660
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000674003300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://sfamjournals.onlinelibrary.wiley.com/doi/10.1111/1462-2920.15660
UR  - http://hdl.handle.net/10044/1/90681
VL  - 23
ER  -
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