Imperial College London
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DrJohannaRhodes

Faculty of Medicine, School of Public Health

Honorary Research Fellow
 
 
 
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Contact

 

johanna.rhodes

 
 
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Location

 

Desk 17Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Brackin:2021:10.1007/s11046-021-00573-x,
author = {Brackin, A and Hemmings, S and Fisher, M and Rhodes, J},
doi = {10.1007/s11046-021-00573-x},
journal = {Mycopathologia},
pages = {589--608},
title = {Fungal genomics in respiratory medicine: what, how and when?},
url = {http://dx.doi.org/10.1007/s11046-021-00573-x},
volume = {186},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Respiratory infections caused by fungal pathogens present a growing global healthconcern and are a major cause of death in immunocompromised patients. Worryingly,coronavirus disease-19 (COVID-19) resulting in acute respiratory distress syndrome,has been shown to predispose some patients to fungal co-infection and secondarypulmonary aspergillosis. Aspergillosis is most commonly caused by the fungalpathogen  Aspergillus fumigatus  and primarily treated using the triazole drug group,however in recent years, this fungus has been rapidly gaining resistance against theseantifungals. This is of serious clinical concern as multi-azole resistant forms ofaspergillosis have a higher risk of mortality when compared against azole-susceptibleinfections. With the increasing numbers of COVID-19 and other classes ofimmunocompromised patients, early diagnosis of fungal infections is critical to ensuringpatient survival. However, time-limited diagnosis is difficult to achieve with currentculture-based methods. Advances within fungal genomics have enabled moleculardiagnostic methods to become a fast, reproducible, and cost-effective alternative fordiagnosis of respiratory fungal pathogens and detection of antifungal resistance. Herewe describe what techniques are currently available within molecular diagnostics, howthey work and when they have been used.
AU  - Brackin,A
AU  - Hemmings,S
AU  - Fisher,M
AU  - Rhodes,J
DO  - 10.1007/s11046-021-00573-x
EP  - 608
PY  - 2021///
SN  - 0301-486X
SP  - 589
TI  - Fungal genomics in respiratory medicine: what, how and when?
T2  - Mycopathologia
UR  - http://dx.doi.org/10.1007/s11046-021-00573-x
UR  - https://link.springer.com/article/10.1007%2Fs11046-021-00573-x
UR  - http://hdl.handle.net/10044/1/91386
VL  - 186
ER  -
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