Publications
368 results found
Chahal NS, Lim TK, Jain P, et al., 2008, Carotid intima-media thickness as a surrogate marker of atherosclerosis and cardiovascular disease risk in healthy UK Indian Asians and European whites, Annual Scientific Conference of the British-Cardiovascular-Society/British-Society-for-Cardiovascular-Research, Publisher: B M J PUBLISHING GROUP, Pages: A8-A9, ISSN: 1355-6037
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- Citations: 1
Sehmi JS, Chambers JC, Kooner JS, 2008, Inflammatory processes are associated with insulin resistance among UK Indian Asians, and not accounted for by obesity, Annual Scientific Conference of the British-Cardiovascular-Society/British-Society-for-Cardiovascular-Research, Publisher: B M J PUBLISHING GROUP, Pages: A38-A39, ISSN: 1355-6037
Chambers JC, Elliott P, Scott J, et al., 2008, Genome-wide association study identifies mlxipl as a novel determinant of trigyceride levels in man, Annual Scientific Conference of the British-Cardiovascular-Society/British-Society-for-Cardiovascular-Research, Publisher: B M J PUBLISHING GROUP, Pages: A5-A5, ISSN: 1355-6037
Chambers JC, Scott J, Meeran K, et al., 2008, Transcription factor 7-like 2, insulin action and risk of type 2 diabetes among Indian Asian and White European men, Annual Scientific Conference of the British-Cardiovascular-Society/British-Society-for-Cardiovascular-Research, Publisher: B M J PUBLISHING GROUP, Pages: A59-A59, ISSN: 1355-6037
Zhang W, Zabaneh D, Balding D, et al., 2008, Are Indian Asians genetically homogeneous? Implications for genetic association studies, Annual Scientific Conference of the British-Cardiovascular-Society/British-Society-for-Cardiovascular-Research, Publisher: B M J PUBLISHING GROUP, Pages: A65-A65, ISSN: 1355-6037
Chambers JC, Zhang W, Zabaneh D, et al., 2008, Does genetic variation in FTO account for the increased risk of obesity and type 2 diabetes in UK Indian Asians?, Annual Scientific Conference of the British-Cardiovascular-Society/British-Society-for-Cardiovascular-Research, Publisher: B M J PUBLISHING GROUP, Pages: A58-A59, ISSN: 1355-6037
Jain P, Chambers JC, Elliott P, et al., 2008, Coronary artery calcification as a predictor of increased coronary heart disease risk in UK Indian Asians, Annual Scientific Conference of the British-Cardiovascular-Society/British-Society-for-Cardiovascular-Research, Publisher: B M J PUBLISHING GROUP, Pages: A77-A77, ISSN: 1355-6037
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- Citations: 1
Chambers JC, Elliott P, Zabaneh D, et al., 2008, Common genetic variation near <i>MC4R</i> is associated with waist circumference and insulin resistance, NATURE GENETICS, Vol: 40, Pages: 716-718, ISSN: 1061-4036
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- Citations: 382
Kooner JS, Chambers JC, Aguilar-Salinas CA, et al., 2008, Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides, Nature Genetics
Chambers JC, Scott J, Hinds DA, et al., 2007, A genome-wide scan identifies novel and known DNA variants associated with component phenotypes of metabolic syndrome, 80th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 507-507, ISSN: 0009-7322
Alakakone A, Tillin T, Chambers J, et al., 2007, Do differences in lower limb blood flow explain the ethnic disparity in peripheral arterial disease incidence between South Asians and Europeans?, 12th Annual Meeting of the European Council for Cardiovascular Research, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 803-803, ISSN: 0194-911X
Lim TK, Lim E, Jain P, et al., 2007, Investigation of the relationship between Type 2 Diabetes and left ventricular function in men and women aged 35-75 years, EUROPEAN HEART JOURNAL, Vol: 28, Pages: 456-456, ISSN: 0195-668X
Zabaneh D, Chambers JC, Elliott P, et al., 2007, Estimating heritabilities and genetic correlations of insulin resistance and related metabolic traits in Indian families using a multivariate maximum likelihood approach, 16th Annual Meeting of the International-Genetic-Epidemiology-Society, Publisher: WILEY-LISS, Pages: 651-651, ISSN: 0741-0395
Tillin T, Chambers J, Malik I, et al., 2007, Measurement of pulse wave velocity: site matters, JOURNAL OF HYPERTENSION, Vol: 25, Pages: 383-389, ISSN: 0263-6352
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- Citations: 65
Chambers JC, Frazer KA, Hinds DA, et al., 2006, Transcription factor 7-like-2 polymorphisms and risk of type 2 diabetes in Indian Asians and Northern Europeans, 79th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 888-888, ISSN: 0009-7322
Chambers JC, Elliott P, Scott J, et al., 2006, Physical activity and risk of type 2 diabetes in UK Indian Asian and Northern European subjects in the London Life Sciences Population (LOLIPOP) study, 79th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 894-895, ISSN: 0009-7322
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- Citations: 1
Chambers JC, Lim E, Elliott P, et al., 2006, The age and gender related patterns of insulin resistance in UK Indian Asians and Northern Europeans: The London Life Sciences Population (LOLIPOP) Study, 79th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 902-903, ISSN: 0009-7322
Lim TK, Lim E, Jain P, et al., 2006, Investigation of the relationship between type 2 diabetes and left ventricular function in men and women aged 35-75 years, 79th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 895-895, ISSN: 0009-7322
Chambers JC, Elliott P, Scott J, et al., 2006, Obesity and risk of Type 2 diabetes in UK Indian Asians and Northern Europeans in the London Life Sciences Population (LOLIPOP) Study, 79th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 854-854, ISSN: 0009-7322
Tillin T, Dhutia H, Chambers J, et al., 2006, British South Asian men have more adverse plaque morphology despite equivalent atherosclerotic burden to White Europeans, 14th International Symposium on Atherosclerosis, Publisher: ELSEVIER IRELAND LTD, Pages: 80-80, ISSN: 1567-5688
Tillin T, Dhutia H, Chambers J, et al., 2006, South Asians have narrower coronary arteries and different remodelling responses to disease compared to white Europeans, 14th International Symposium on Atherosclerosis, Publisher: ELSEVIER IRELAND LTD, Pages: 80-80, ISSN: 1567-5688
Chambers J, Lim E, Jain P, et al., 2006, The age and gender related prevalence of the metabolic syndrome among UK Indian Asians and European whites: First results from the London Life Sciences Population (LOLIPOP) Study, Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health, Publisher: B M J PUBLISHING GROUP, Pages: A11-A12, ISSN: 1355-6037
Chambers J, Lim E, Singh D, et al., 2006, Investigation of cardiovascular risk factors among UK Indian Asians and European whites: The London Life Sciences Population (LOLIPOP) Study, Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health, Publisher: B M J PUBLISHING GROUP, Pages: A12-A12, ISSN: 1355-6037
Lim E, Lightstone L, Chambers J, et al., 2006, Chronic kidney disease as a cardiovascular risk factor in UK Indian Asians compared to UK Northern Europeans: The London Life Sciences Prospective Population Study (LOLIPOP), Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health, Publisher: B M J PUBLISHING GROUP, Pages: A12-A12, ISSN: 1355-6037
Chambers JC, Pepper JR, 2003, Surgical options in the management of heart failure, Continuing Medical Education - Cardiology, Vol: 2, Pages: 166-176, ISSN: 1463-0486
Chambers JC, Wander GS, Hooper J, et al., 2003, Plasma homocysteine and coronary heart disease mortality in India, Annual Scientific Conference of the British-Cardiac-Society, Publisher: B M J PUBLISHING GROUP, Pages: A58-A58, ISSN: 1355-6037
Chambers JC, Kooner JS, 2002, Diagnosis and risk stratification of unstable angina and non ST-segment elevation myocardial infarction, Continuing Medical Education - Cardiology, Vol: 2, Pages: 15-29, ISSN: 1463-0486
Patients with acute coronary syndromes (ACS) are at increased risk of death, and non-fatal MI. Rapid diagnosis and accurate risk stratification facilitates delivery of prompt and appropriate therapy, improving outcomes. Patients with symptoms of myocardial ischaemia, occurring in an accelerating pattern or at rest, but without ST-segment elevation or new LBBB on the electrocardiogram (ECG), should be considered to have unstable angina/non ST-segment elevation myocardial infarction (UA/NSTEMI) until proven otherwise. This is true even if the initial ECG and cardiac enzymes are normal. An ischaemic ECG or elevated cardiac enzymes confirms the diagnosis. Patients with definite UA/NSTEMI should be stratified as high, intermediate or low risk. Risk stratification guides both the pace of further investigation, and the selection of therapy. Risk stratification starts at the time of admission, and uses clinical, ECG and cardiac markers. High risk patients (recurrent pain, ST-segment shift, or positive cardiac markers) benefit from an invasive management strategy, and should proceed to early angiography. Patients initially considered at low or intermediate risk do not necessarily benefit from an early invasive management strategy, and their prognosis may be better with medical therapy. These patients should be repeatedly reassessed for changes in symptoms, ECG, and cardiac markers, and have non-invasive functional tests in order to identify the subset of patients who are at high risk of cardiac events.
Chambers JC, Anand IS, Wander GS, et al., 2002, Plasma homocysteine and coronary heart disease mortality in India, American-Heart-Association Abstracts From Scientific Sessions, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 732-733, ISSN: 0009-7322
Clarke R, Collins R, Lewington S, et al., 2002, Homocysteine and risk of ischemic heart disease and stroke -: A meta-analysis, JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Vol: 288, Pages: 2015-2022, ISSN: 0098-7484
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- Citations: 1682
Klerk M, Verhoef P, Clarke R, et al., 2002, MTHFR 677C-->T polymorphism and risk of coronary heart disease: a meta-analysis., JAMA, Vol: 288, Pages: 2023-2031, ISSN: 0098-7484
CONTEXT: In observational studies, individuals with elevated levels of plasma homocysteine tend to have moderately increased risk of coronary heart disease (CHD). The MTHFR 677C-->T polymorphism is a genetic alteration in an enzyme involved in folate metabolism that causes elevated homocysteine concentrations, but its relevance to risk of CHD is uncertain. OBJECTIVE: To assess the relation of MTHFR 677C-->T polymorphism and risk of CHD by conducting a meta-analysis of individual participant data from all case-control observational studies with data on this polymorphism and risk of CHD. DATA SOURCES: Studies were identified by searches of the electronic literature (MEDLINE and Current Contents) for relevant reports published before June 2001 (using the search terms MTHFR and coronary heart disease), hand searches of reference lists of original studies and review articles (including meta-analyses) on this topic, and contact with investigators in the field. STUDY SELECTION: Studies were included if they had data on the MTHFR 677C-->T genotype and a case-control design (retrospective or nested case-control) and involved CHD as an end point. Data were obtained from 40 (34 published and 6 unpublished) observational studies involving a total of 11 162 cases and 12 758 controls. DATA EXTRACTION: Data were collected on MTHFR 677C-->T genotype, case-control status, and plasma levels of homocysteine, folate, and other cardiovascular risk factors. Data were checked for consistency with the published article or with information provided by the investigators and converted into a standard format for incorporation into a central database. Combined odds ratios (ORs) for the association between the MTHFR 677C-->T polymorphism and CHD were assessed by logistic regression. DATA SYNTHESIS: Individuals with the MTHFR 677 TT genotype had a 16% (OR, 1.16; 95% confidence interval [CI], 1.05-1.28) higher odds of CHD compared with individuals with the CC genotype. There was sig
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