Imperial College London

Kok Meng John Chan

Faculty of MedicineNational Heart & Lung Institute

Honorary Senior Clinical Research Fellow
 
 
 
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Contact

 

+44 (0)20 7351 8530john.chan98 Website

 
 
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Assistant

 

Mr John Pepper +44 (0)20 7351 8530

 
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Location

 

Prof Pepper's OfficeChelsea WingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

28 results found

Dulguerov F, Marcacci C, Alexandrescu C, Chan KM, Dreyfus GDet al., 2016, Hypertrophic obstructive cardiomyopathy: the mitral valve could be the key., European Journal of Cardio-Thoracic Surgery, ISSN: 1010-7940

OBJECTIVES: As we strongly believe that treating the mitral valve abnormalities is a key feature of hypertrophic obstructive cardiomyopathy (HOCM), we have systematically corrected both the anterior and posterior leaflet (PL) size and geometry. We have analysed our immediate results and at mid-term follow-up. METHODS: From March 2010 until June 2015, 16 patients with HOCM underwent surgical correction of obstruction. The mean age was 51 years old (range, 32-72 years). All were symptomatic being New York Heart Association (NYHA) class 3 (n = 4) or 4 (n = 12). All had systolic anterior motion at echocardiogram with severe mitral regurgitation (MR). Intraventricular gradient preoperatively was 73.5 mmHg (range, 50-120 mmHg). All patients underwent a double-stage procedure: first septal resection through (i) the aortic valve and (ii) the detached anterior leaflet (AL) of the mitral valve and at second, mitral valve repair by (i) reducing PL height (leaflet resection or artificial neochordae) (ii) increasing AL height with pericardial patch. RESULTS: There was no in-hospital or late death. All patients were Class 1 NYHA at latest follow-up. Control echocardiography showed no MR, mean rest intraventricular gradient was 15 mmHg (range, 9-18 mmHg). CONCLUSIONS: Our good mid-term results support the concept that HOCM is not only a septal disease and that the mitral valve pathology is a key component that should be addressed. For most patients, the ideal surgical treatment should consist in a two-step procedure. It is even necessary to be studied whether treating the mitral valve alone could not suffice.

Journal article

Dreyfus GD, Martin RP, Chan KMJ, Dulguerov F, Alexandrescu Cet al., 2015, Functional Tricuspid Regurgitation A Need to Revise Our Understanding, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 65, Pages: 2331-2336, ISSN: 0735-1097

Journal article

Chan KMJ, Pepper JR, 2015, Surgical Treatment of Moderate Ischemic Mitral Regurgitation, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 372, Pages: 1770-1771, ISSN: 0028-4793

Journal article

Chan K, Dreyfus G, 2014, Tricuspid Valve Surgery, Cardiac Surgery: Recent Advances and Techniques, Editors: Moorjani, Ohri, Wechsler, Boca Raton, FL, USA, Publisher: CRC Press, Pages: 67-75, ISBN: 978-1-4441-3756-9

Book chapter

Chan KMJ, 2013, Ischaemic mitral regurgitation: randomised evaluation of surgical treatment and study of its pathophysiology and predictors of outcome

Thesis dissertation

Punjabi PP, Chan KMJ, 2012, Technique for Chordae Replacement in Mitral Valve Repair, ANNALS OF THORACIC SURGERY, Vol: 94, Pages: 2139-2140, ISSN: 0003-4975

Journal article

Chan KMJ, Punjabi PP, Flather M, Wage R, Symmonds K, Roussin I, Rahman-Haley S, Pennell DJ, Kilner PJ, Dreyfus GD, Pepper JRet al., 2012, Coronary Artery Bypass Surgery With or Without Mitral Valve Annuloplasty in Moderate Functional Ischemic Mitral Regurgitation Final Results of the Randomized Ischemic Mitral Evaluation (RIME) Trial, CIRCULATION, Vol: 126, Pages: 2502-+, ISSN: 0009-7322

Journal article

Shiina Y, Chan KM, Pennell DJ, Pepper J, Kilner PJet al., 2012, Late systolic mitral prolapse and regurgitation is associated with impaired papillary muscle and enhanced inferolateral wall long axis function measured by magnetic resonance, Congress of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 213-213, ISSN: 0195-668X

Conference paper

Treasure T, Crowe S, Chan KMJ, Ranasinghe A, Attia R, Lees B, Utley M, Golesworthy T, Pepper Jet al., 2012, A method for early evaluation of a recently introduced technology by deriving a comparative group from existing clinical data: a case study in external support of the Marfan aortic root, BMJ OPEN, Vol: 2, ISSN: 2044-6055

Journal article

Chan KMJ, Wage R, Symmonds K, Roussin I, Flather M, Pennell DJ, Prasad SK, Kilner PJ, Pepper JRet al., 2011, Mitral Valve Annuloplasty in Addition to Coronary Artery Bypass Grafting in Moderate Functional Ischemic Mitral Regurgitation Reverses Left Ventricular Remodelling and Restores Left Ventricular Geometry: Preliminary Results of the Randomised Ischemic Mitral Evaluation Trial, CIRCULATION, Vol: 124, ISSN: 0009-7322

Journal article

Chan KMJ, Wage R, Symmonds K, Roussin I, Flather M, Pennell DJ, Prasad SK, Kilner PJ, Pepper JRet al., 2011, Mitral Valve Annular, Leaflet and Papillary Muscle Geometry and Function in Functional Ischemic Mitral Regurgitation: New Insights from Cardiovascular Magnetic Resonance, CIRCULATION, Vol: 124, ISSN: 0009-7322

Journal article

Nawaz MA, Patni R, Chan KMJ, Lockwood G, Punjabi PPet al., 2011, Hyperinflation of lungs during redo-sternotomy, a safer technique, Heart Lung and Circulation, Vol: 20, Pages: 722-723

Journal article

Jarral OA, Jarral RA, Chan KMJ, Punjabi PPet al., 2011, Use of a purse string suture in proximal coronary anastomosis to reduce size mismatch between conduit and aortotomy, Annals of the Royal College of Surgeons of England, Vol: 93, Pages: 415-416

Journal article

Chan KMJ, Rahman-Haley S, Mittal TK, Gavino JTA, Dreyfus GDet al., 2011, Truly stentless autologous pericardial aortic valve replacement: an alternative to standard aortic valve replacement., Journal of Thoracic and Cardiovascular Surgery, Pages: 276-283

Journal article

Pepper J, Chan KMJ, Gavino J, Golesworthy T, Mohiaddin R, Treasure Tet al., 2010, External aortic root support for Marfan syndrome: early clinical results in the first 20 recipients with a bespoke implant, JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, Vol: 103, Pages: 370-375, ISSN: 0141-0768

Journal article

Pepper J, Golesworthy T, Utley M, Chan J, Ganeshalingam S, Lamperth M, Mohiaddin R, Treasure Tet al., 2010, Manufacturing and placing a bespoke support for the Marfan aortic root: description of the method and technical results and status at one year for the first ten patients, INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, Vol: 10, Pages: 360-365, ISSN: 1569-9293

Journal article

Zakkar M, Chan KMJ, Amirak E, Herrey A, Punjabi PPet al., 2009, Infective Endocarditis of the Mitral Valve: Optimal Management, PROGRESS IN CARDIOVASCULAR DISEASES, Vol: 51, Pages: 472-477, ISSN: 0033-0620

Journal article

Chan KMJ, Zakkar M, Amirak E, Punjabi PPet al., 2009, Tricuspid Valve Disease: Pathophysiology and Optimal Management, PROGRESS IN CARDIOVASCULAR DISEASES, Vol: 51, Pages: 482-486, ISSN: 0033-0620

Journal article

Amirak E, Chan KMJ, Zakkar M, Punjabi PPet al., 2009, Current Status of Surgery for Degenerative Mitral Valve Disease, PROGRESS IN CARDIOVASCULAR DISEASES, Vol: 51, Pages: 454-459, ISSN: 0033-0620

Journal article

Chan KMJ, Amirak E, Zakkar M, Flather M, Pepper JR, Punjabi PPet al., 2009, Ischemic Mitral Regurgitation: In Search of the Best Treatment for a Common Condition, PROGRESS IN CARDIOVASCULAR DISEASES, Vol: 51, Pages: 460-471, ISSN: 0033-0620

Journal article

Zakkar M, Amirak E, Chan KMJ, Punjabi PPet al., 2009, Rheumatic Mitral Valve Disease: Current Surgical Status, PROGRESS IN CARDIOVASCULAR DISEASES, Vol: 51, Pages: 478-481, ISSN: 0033-0620

Journal article

Dreyfus GD, Chan KMJ, 2009, Functional tricuspid regurgitation: a more complex entity than it appears., Heart, Pages: 868-869

Journal article

Chan KM, Wage R, Symmonds K, Rahman-Haley S, Mohiaddin RH, Firmin DN, Pepper JR, Pennell DJ, Kilner PJet al., 2008, Towards comprehensive assessment of mitral regurgitation using cardiovascular magnetic resonance. Chan KM, Wage, J Cardiovasc Magn Reson., Vol: 22

Journal article

Dreyfus GD, Raja S, Chan KMJ, 2008, Tricuspid leaflet augmentation to address severe tethering in functional tricuspid regurgitation., European Journal of Cardiothoracic Surgery, Pages: 908-910

Journal article

Dreyfus GD, Corbi PJ, Chan KMJ, Bahrami Tet al., 2005, Secondary tricuspid regurgitation or dilatation: which should be the criteria for surgical repair?, Ann Thorac Surg, Vol: 79, Pages: 127-132

BACKGROUND: Secondary tricuspid dilatation may or not be accompanied by tricuspid regurgitation (TR). Tricuspid dilatation can be objectively measured whereas TR can vary according to the preload, afterload, and right ventricular function. The purpose of this prospective study was to determine whether surgical repair of the tricuspid valve based on tricuspid dilatation rather than TR could lead to potential benefits. METHODS: Between 1989 and 2001, 311 patients underwent mitral valve repair (MVR). The tricuspid valve was examined in each patient. Tricuspid annuloplasty was performed only if the tricuspid annular diameter was greater than twice the normal size (> or = 70 mm) regardless of the grade of regurgitation. Patients in group 1 (163 patients; 52.4%) received MVR alone. Patients in group 2 (148 patients; 47.6%) received MVR plus tricuspid annuloplasty. RESULTS: Although not significant there was a difference with regard to hospital mortality (group 1 = 1.8%, group 2 = 0.7%) and actuarial survival rate (Kaplan-Meier: group 1 = 97.3%, 96.2%, and 85.5%; group 2 = 98.5%, 98.5%, and 90.3% at 3, 5, and 10 years, respectively). The New York Heart Association (NYHA) functional class was significantly improved in group 2 (group 1 = 1.59 +/- 0.84; group 2 = 1.11 +/- 0.31; p1). TR increased by more than two grades in 48% of the patients in group 1 and in only 2% of the patients in group 2 (p < 0.001). CONCLUSIONS: Remodeling annuloplasty of the tricuspid valve based on tricuspid dilation improves functional status irrespective of the grade of regurgitation. Considerable tricuspid dilatation can be present even in the absence of substantial TR. Tricuspid dilatation is an ongoing disease process that will, with time, lead to severe TR.

Journal article

Dixon K, Agrawal B, Chan KMJ, 2002, Determining the influence of biocompatible oxygenators during cardiopulmonary bypass by 99mTc-DTPA aerosol assessment of pulmonary permeability., Nuclear Medicine Communications, Vol: 23, Pages: 275-282

Journal article

Graham A, Chan KMJ, Pastorino U, Goldstraw Pet al., 1999, Systematic nodal dissection in the intra-thoracic staging of patients with non-small cell lung cancer., Journal of Thoracic and Cardiovascular Surgery, Vol: 117, Pages: 246-251

Journal article

Patel S, Chan KMJ, Hosking D, 1996, Fluoride pharmacokinetics and changes in lumbar spine and hip bone mineral density, Bone, Pages: 651-655

Journal article

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