Imperial College London


Faculty of Natural SciencesDepartment of Life Sciences

Senior Research Investigator



+44 (0)20 7594 9723jonathan.lamb




6166Sir Alexander Fleming BuildingSouth Kensington Campus





Jonathan Lamb returned to Imperial College in 2009 to the Chair of Immunoregulation in the Division of Cell and Molecular Biology, having previously been the Professor of Immunology at St. Mary's Hospital Medical School/Department of Biology at Imperial College from 1990 to 1997. During the interim period he was the Professor of Respiratory Science at Edinburgh University and Head of UK Human Biomarker Laboratory, GlaxoSmithKline, Addenbrooke's Hospital, Cambridge. Following undergraduate degrees at Edinburgh and Oxford Universities he completed his PhD in immunology in 1980 at London University. Jonathan has been a scientific board member for a number of organisations including the MRC, WHO, and ARC and is currently a member of the BBSRC pool of experts.

In brief Jonathan’s research interests focus on the regulation of inflammatory responses in particular how the host deciphers and integrates internal and external signals that determine the outcome of protective and pathogenic immunity. Understanding the underlying mechanisms that lead to inappropriate immune responses has potential applications in the longer-term by contributing to the development of new treatments of a variety of diseases. In order to address these scientific questions he is using zebrafish to model mammalian disease phenotypes and to study host inflammatory responses in real-time from the molecular to whole organism level.



Chang Y-Y, Huan Q-C, Peng J, et al., 2022, P2Y1R Ligation Suppresses Th17 Cell Differentiation and Alleviates Colonic Inflammation in an AMPK-Dependent Manner, Frontiers in Immunology, Vol:13, ISSN:1664-3224

Fu M, Tan L, Lin Z, et al., 2021, Down-regulation of STAT3 enhanced chemokine expression and neutrophil recruitment in biliary atresia, Clinical Science, Vol:135, ISSN:0143-5221, Pages:865-884

Zhang R, Lin Z, Fu M, et al., 2018, The Role of Neonatal Gr-1<SUP>+</SUP> Myeloid Cells in a Murine Model of Rhesus-Rotavirus-Induced Biliary Atresia, American Journal of Pathology, Vol:188, ISSN:0002-9440, Pages:2617-2628

Zhang R-Z, Zeng X-H, Lin Z-F, et al., 2018, Downregulation of Hes1 expression in experimental biliary atresia and its effects on bile duct structure, World Journal of Gastroenterology, Vol:24, ISSN:1007-9327, Pages:3260-3272

Zhang R, Lin Z, Lui VCH, et al., 2017, Silver nanoparticle treatment ameliorates biliary atresia syndrome in rhesus rotavirus inoculated mice, Nanomedicine-nanotechnology Biology and Medicine, Vol:13, ISSN:1549-9634, Pages:1041-1050

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