Imperial College London

ProfessorJonathanLamb

Faculty of Natural SciencesDepartment of Life Sciences

Senior Research Investigator
 
 
 
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Contact

 

+44 (0)20 7594 9723jonathan.lamb

 
 
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Location

 

6166Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

187 results found

Chang Y-Y, Huan Q-C, Peng J, Bi W-C, Zhai L-X, Chen Y, Lamb JR, Shen X-C, Bian Z-X, Wu H-Q, Cheng Y-X, Xiao H-Tet al., 2022, P2Y1R Ligation Suppresses Th17 Cell Differentiation and Alleviates Colonic Inflammation in an AMPK-Dependent Manner, FRONTIERS IN IMMUNOLOGY, Vol: 13, ISSN: 1664-3224

Journal article

Fu M, Tan L, Lin Z, Lui VCH, Tam PKH, Lamb JR, Zhang Y, Xia H, Zhang R, Chen Yet al., 2021, Down-regulation of STAT3 enhanced chemokine expression and neutrophil recruitment in biliary atresia, CLINICAL SCIENCE, Vol: 135, Pages: 865-884, ISSN: 0143-5221

Journal article

Zhang R, Lin Z, Fu M, Guan X, Yu J, Zhong W, Zeng J, Lui VCH, Tam PKH, Lamb JR, Xia H, Chen Yet al., 2018, The Role of Neonatal Gr-1(+) Myeloid Cells in a Murine Model of Rhesus-Rotavirus-Induced Biliary Atresia, AMERICAN JOURNAL OF PATHOLOGY, Vol: 188, Pages: 2617-2628, ISSN: 0002-9440

Journal article

Zhang R-Z, Zeng X-H, Lin Z-F, Ming-Fu, Tong Y-L, Lui VCH, Tam PKH, Lamb JR, Xia H-M, Chen Yet al., 2018, Downregulation of Hes1 expression in experimental biliary atresia and its effects on bile duct structure, WORLD JOURNAL OF GASTROENTEROLOGY, Vol: 24, Pages: 3260-3272, ISSN: 1007-9327

Journal article

Zhang R, Lin Z, Lui VCH, Wong KKY, Tam PKH, Lee P, Lok CN, Lamb JR, Chen Y, Xia Het al., 2017, Silver nanoparticle treatment ameliorates biliary atresia syndrome in rhesus rotavirus inoculated mice, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, Vol: 13, Pages: 1041-1050, ISSN: 1549-9634

Journal article

Progatzky F, Cook HT, Lamb JR, Bugeon L, Dallman MJet al., 2016, Mucosal inflammation at the respiratory interface: a zebrafish model, AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, Vol: 310, Pages: L551-L561, ISSN: 1040-0605

Journal article

Zhang R-Z, Yu J-K, Peng J, Wang F-H, Liu H-Y, Lui VCH, Nicholls JM, Tam PKH, Lamb JR, Chen Y, Xia H-Met al., 2016, Role of CD56-expressing immature biliary epithelial cells in biliary atresia, WORLD JOURNAL OF GASTROENTEROLOGY, Vol: 22, Pages: 2545-2557, ISSN: 1007-9327

Journal article

Peng J, Tsang JY, Ho DH, Zhang R, Xiao H, Li D, Zhu J, Wang F, Bian Z, Lui VC, Xu A, Tam PK, Lamb JR, Xia H, Chen Yet al., 2015, Modulatory effects of adiponectin on the polarization of tumor-associated macrophages, INTERNATIONAL JOURNAL OF CANCER, Vol: 137, Pages: 848-858, ISSN: 0020-7136

Journal article

Progatzky F, Sangha NJ, Yoshida N, McBrien M, Cheung J, Shia A, Scott J, Marchesi JR, Lamb JR, Bugeon L, Dallman MJet al., 2014, Dietary cholesterol directly induces acute inflammasome-dependent intestinal inflammation, Nature Communications, Vol: 5, Pages: 1-14, ISSN: 2041-1723

Prolonged ingestion of a cholesterol- or saturated fatty acid-enriched diet induces chronic, often systemic, auto-inflammatory responses resulting in significant health problems worldwide. In vivo information regarding the local and direct inflammatory effect of these dietary components in the intestine and, in particular, on the intestinal epithelium is lacking. Here we report that both mice and zebrafish exposed to high-fat (HFDs) or high-cholesterol (HCDs) diets develop acute innate inflammatory responses within hours, reflected in the localized interleukin-1β-dependent accumulation of myeloid cells in the intestine. Acute HCD-induced intestinal inflammation is dependent on cholesterol uptake via Niemann-Pick C1-like 1 and inflammasome activation involving apoptosis-associated Speck-like protein containing a caspase recruitment domain, which leads to Caspase-1 activity in intestinal epithelial cells. Extended exposure to HCD results in localized, inflammation-dependent, functional dysregulation as well as systemic pathologies. Our model suggests that dietary cholesterol initiates intestinal inflammation in epithelial cells.

Journal article

Progatzky F, Sangha NJ, Yoshida N, McBrien M, Cheung J, Shia A, Scott J, Marchesi JR, Lamb JR, Bugeon L, Dallman MJet al., 2014, Intestinal inflammation induced by dietary cholesterol in Zebrafish, 9th European-Mucosal-Immunology-Group Meeting, Publisher: WILEY-BLACKWELL, Pages: 27-28, ISSN: 0019-2805

Conference paper

Liu Y-H, Tan KAL, Morrison IW, Lamb JR, Argyle DJet al., 2013, Macrophage migration is controlled by Tribbles 1 through the interaction between C/EBP beta and TNF-alpha, VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, Vol: 155, Pages: 67-75, ISSN: 0165-2427

Journal article

Peng J, Tsang JYS, Li D, Niu N, Ho DHH, Lau KF, Lui VCH, Lamb JR, Chen Y, Tam PKHet al., 2013, Inhibition of TGF-beta signaling in combination with TLR7 ligation re-programs a tumoricidal phenotype in tumor-associated macrophages, CANCER LETTERS, Vol: 331, Pages: 239-249, ISSN: 0304-3835

Journal article

Taylor HB, Liepe J, Barthen C, Bugeon L, Huvet M, Kirk PDW, Brown SB, Lamb JR, Stumpf MPH, Dallman MJet al., 2012, P38 and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish, Immunology and Cell Biology, Vol: 91, Pages: 60-69, ISSN: 1440-1711

The recruitment and migration of macrophages and neutrophils is an important process during the early stages of the innate immune system in response to acute injury. Transgenic pu.1:EGFP zebrafish permit the acquisition of leukocyte migration trajectories during inflammation. Currently, these high-quality live-imaging data are mainly analysed using general statistics, for example, cell velocity. Here, we present a spatio-temporal analysis of the cell dynamics using transition matrices, which provide information of the type of cell migration. We find evidence that leukocytes exhibit types of migratory behaviour, which differ from previously described random walk processes. Dimethyl sulfoxide treatment decreased the level of persistence at early time points after wounding and ablated temporal dependencies observed in untreated embryos. We then use pharmacological inhibition of p38 and c-Jun N-terminal kinase mitogen-activated protein kinases to determine their effects on in vivo leukocyte migration patterns and discuss how they modify the characteristics of the cell migration process. In particular, we find that their respective inhibition leads to decreased and increased levels of persistent motion in leukocytes following wounding. This example shows the high level of information content, which can be gained from live-imaging data if appropriate statistical tools are used.

Journal article

Progatzky F, Taylor H, Bugeon L, Cassidy S, Radbruch A, Dallman MJ, Lamb JRet al., 2012, The role of Nfil3 in zebrafish hematopoiesis, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, Vol: 38, Pages: 187-192, ISSN: 0145-305X

Journal article

Peng J, Li D, Chan YK, Chen Y, Lamb JR, Tam PKH, El-Nezami Het al., 2012, Effects of water uptake on melamine renal stone formation in mice, NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol: 27, Pages: 2225-2231, ISSN: 0931-0509

Journal article

Chen L, McGinty J, Taylor HB, Bugeon L, Lamb JR, Dallman MJ, French PMWet al., 2012, Incorporation of an experimentally determined MTF for spatial frequency filtering and deconvolution during optical projection tomography reconstruction, OPTICS EXPRESS, Vol: 20, Pages: 7323-7337, ISSN: 1094-4087

Journal article

Liepe J, Taylor H, Barnes CP, Huvet M, Bugeon L, Thorne T, Lamb JR, Dallman MJ, Stumpf MPHet al., 2012, Calibrating spatio-temporal models of leukocyte dynamics against in vivo live-imaging data using approximate Bayesian computation, INTEGRATIVE BIOLOGY, Vol: 4, Pages: 335-345, ISSN: 1757-9694

Journal article

Chen L, McGinty J, Taylor HB, Bugeon L, Lamb JR, Dallman MJ, French Pet al., 2012, Improved OPT reconstructions based on the MTF and extension to FLIM-OPT

We demonstrate the improved reconstruction of OPT datasets by incorporating the measured MTF in the reconstruction process. We also extend OPT to FLIM-OPT and demonstrate its use for imaging live zebrafish embryos displaying autofluorescence. © 2012 OSA.

Conference paper

Li D, Tsang JYS, Peng J, Ho DHH, Chan YK, Zhu J, Lui VCH, Xu A, Lamb JR, Tam PKH, Chen Yet al., 2012, Adiponectin mediated MHC class II mismatched cardiac graft rejection in mice is IL-4 dependent., PLoS One, Vol: 7

BACKGROUND: Adiponectin regulates glucose and fatty-acid metabolism but its role in chronic graft rejection mediated by Th2 cytokines remains ill-defined. METHODOLOGY/PRINCIPAL FINDINGS: Wild type and adiponectin-null mice were used as graft recipients in mouse MHC class II disparate cardiac transplantation (bm12 toB6) and the graft rejection was monitored. In adiponectin-null mice we observed that the cellular infiltrate of eosinophils, CD4(+) and CD8(+) T cells was reduced in grafts compared to the controls as was collagen deposition and vessel occlusion. A similar outcome was observed for skin transplants except that neutrophil infiltration was increased. Low levels of IL-4 were detected in the grafts and serum. The effect of adiponectin signaling on IL-4 expression was further investigated. Treatment with AMPK and p38 MAPK inhibitors blocked adiponectin enhanced T cell proliferation in mixed lymphocyte reactions. Inhibition of AMPK reduced eosinophil infiltration in skin grafts in wild type recipients and in contrast AMPK activation increased eosinophils in adiponectin-null recipients. The addition of adiponectin increased IL-4 production by the T cell line EL4 with augmented nuclear GATA-3 and phospho-STAT6 expression which were suppressed by knockdown of adiponectin receptor 1 and 2. CONCLUSIONS: Our results demonstrate a direct effect of adiponectin on IL-4 expression which contributes to Th2 cytokine mediated rejection in mouse MHC class II histoincompatible transplants. These results add to our understanding of the interrelationship of metabolism and immune regulation and raise the possibility that AMPK inhibitors may be beneficial in selected types of rejection.

Journal article

Lara R, Mauri FA, Taylor H, Derua R, Shia A, Gray C, Nicols A, Shiner RJ, Schofield E, Bates PA, Waelkens E, Dallman M, Lamb J, Zicha D, Downward J, Seckl MJ, Pardo OEet al., 2011, An siRNA screen identifies RSK1 as a key modulator of lung cancer metastasis, ONCOGENE, Vol: 30, Pages: 3513-3521, ISSN: 0950-9232

Journal article

Chen Y, Li D, Tsang JYS, Niu N, Peng J, Zhu J, Hui K, Xu A, Lui VCH, Lamb JR, Tam PKHet al., 2011, PPAR-gamma signaling and IL-5 inhibition together prevent chronic rejection of MHC Class II mismatched cardiac grafts, JOURNAL OF HEART AND LUNG TRANSPLANTATION, Vol: 30, Pages: 698-706, ISSN: 1053-2498

Journal article

Weller CL, Collington SJ, Williams T, Lamb JRet al., 2011, Mast cells in health and disease, CLINICAL SCIENCE, Vol: 120, Pages: 473-484, ISSN: 0143-5221

Journal article

Pridgeon C, Bugeon L, Donnelly L, Straschil U, Tudhope SJ, Fenwick P, Lamb JR, Barnes PJ, Dallman MJet al., 2011, Regulation of IL-17 in chronic inflammation in the human lung., Clin Sci (Lond), Vol: 120, Pages: 515-524

The regulation of human Th17 cell effector function by Treg cells (regulatory T-cells) is poorly understood. In the present study, we report that human Treg (CD4(+)CD25(+)) cells inhibit the proliferative response of Th17 cells but not their capacity to secrete IL (interleukin)-17. However, they could inhibit proliferation and cytokine production by Th1 and Th2 cells as determined by IFN-γ (interferon-γ) and IL-5 biosynthesis. Currently, as there is interest in the role of IL-17-producing cells and Treg cells in chronic inflammatory diseases in humans, we investigated the presence of CD4(+)CD25(+) T-cells and IL-17 in inflammation in the human lung. Transcripts for IL-17 were expressed in mononuclear cells and purified T-cells from lung tissue of patients with chronic pulmonary inflammation and, when activated, these cells secrete soluble protein. The T-cell-specific transcription factors RORCv2 (retinoic acid-related orphan receptor Cv2; for Th17) and FOXP3 (forkhead box P3; for Treg cells) were enriched in the T-cell fraction of lung mononuclear cells. Retrospective stratification of the patient cohort into those with COPD (chronic obstructive pulmonary disease) and non-COPD lung disease revealed no difference in the expression of IL-17 and IL-23 receptor between the groups. We observed that CD4(+)CD25(+) T-cells were present in comparable numbers in COPD and non-COPD lung tissue and with no correlation between the presence of CD4(+)CD25(+) T-cells and IL-17-producing cells. These results suggest that IL-17-expressing cells are present in chronically inflamed lung tissue, but there is no evidence to support this is due to the recruitment or expansion of Treg cells.

Journal article

McGinty J, Taylor HB, Chen L, Bugeon L, Lamb JR, Dallman MJ, French PMWet al., 2011, In vivo fluorescence lifetime optical projection tomography, Biomedical Optics Express, Vol: 2, Pages: 1340-1350, ISSN: 2156-7085

We demonstrate the application of fluorescence lifetime optical projection tomography (FLIM-OPT) to in vivo imaging of lysC:GFP transgenic zebrafish embryos (Danio rerio). This method has been applied to unambiguously distinguish between the fluorescent protein (GFP) signal in myeloid cells from background autofluorescence based on the fluorescence lifetime. The combination of FLIM, an inherently ratiometric method, in conjunction with OPT results in a quantitative 3-D tomographic technique that could be used as a robust method for in vivo biological and pharmaceutical research, for example as a readout of Förster resonance energy transfer based interactions.

Journal article

Urbanowicz RA, Lamb JR, Todd I, Corne JM, Fairclough LCet al., 2010, Enhanced effector function of cytotoxic cells in the induced sputum of COPD patients, RESPIRATORY RESEARCH, Vol: 11

Journal article

Urbanowicz RA, Lamb JR, Todd I, Corne JM, Fairclough LCet al., 2009, Altered effector function of peripheral cytotoxic cells in COPD, RESPIRATORY RESEARCH, Vol: 10, ISSN: 1465-993X

Journal article

Mellanby RJ, Thomas DC, Lamb J, 2009, Role of regulatory T-cells in autoimmunity, CLINICAL SCIENCE, Vol: 116, Pages: 639-649, ISSN: 0143-5221

Journal article

Lockhart A, Lamb JR, Osredkar T, Sue LI, Joyce JN, Ye L, Libri V, Leppert D, Beach TGet al., 2007, PIB is a non-specific imaging marker of amyloid-beta (A beta) peptide-related cerebral amyloidosis, BRAIN, Vol: 130, Pages: 2607-2615, ISSN: 0006-8950

Journal article

Chen Y, Liu Y, Yuan Z, Tian L, Dallman MJ, Thompson PW, Tam PKH, Lamb JRet al., 2007, Rosiglitazone suppresses cyclosporin-induced chronic transplant dysfunction and prolongs survival of rat cardiac allografts, TRANSPLANTATION, Vol: 83, Pages: 1602-1610, ISSN: 0041-1337

Journal article

Chen Y, Li X, Tian L, Lui VCH, Dallman MJ, Lamb JR, Tam PKHet al., 2007, Inhibition of sonic hedgehog signaling reduces chronic rejection and prolongs allograft survival in a rat orthotopic small bowel transplantation model, TRANSPLANTATION, Vol: 83, Pages: 1351-1357, ISSN: 0041-1337

Journal article

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