182 results found
Zhang R, Lin Z, Fu M, et al., 2018, The Role of Neonatal Gr-1(+) Myeloid Cells in a Murine Model of Rhesus-Rotavirus-Induced Biliary Atresia, AMERICAN JOURNAL OF PATHOLOGY, Vol: 188, Pages: 2617-2628, ISSN: 0002-9440
Zhang R-Z, Zeng X-H, Lin Z-F, et al., 2018, Downregulation of Hes1 expression in experimental biliary atresia and its effects on bile duct structure, WORLD JOURNAL OF GASTROENTEROLOGY, Vol: 24, Pages: 3260-3272, ISSN: 1007-9327
Zhang R, Lin Z, Lui VCH, et al., 2017, Silver nanoparticle treatment ameliorates biliary atresia syndrome in rhesus rotavirus inoculated mice, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, Vol: 13, Pages: 1041-1050, ISSN: 1549-9634
Progatzky F, Cook HT, Lamb JR, et al., 2016, Mucosal inflammation at the respiratory interface: a zebrafish model, AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, Vol: 310, Pages: L551-L561, ISSN: 1040-0605
Zhang R-Z, Yu J-K, Peng J, et al., 2016, Role of CD56-expressing immature biliary epithelial cells in biliary atresia, WORLD JOURNAL OF GASTROENTEROLOGY, Vol: 22, Pages: 2545-2557, ISSN: 1007-9327
Peng J, Tsang JY, Ho DH, et al., 2015, Modulatory effects of adiponectin on the polarization of tumor-associated macrophages, INTERNATIONAL JOURNAL OF CANCER, Vol: 137, Pages: 848-858, ISSN: 0020-7136
Progatzky F, Sangha NJ, Yoshida N, et al., 2014, Dietary cholesterol directly induces acute inflammasome-dependent intestinal inflammation, Nature Communications, Vol: 5, Pages: 1-14, ISSN: 2041-1723
Prolonged ingestion of a cholesterol- or saturated fatty acid-enriched diet induces chronic, often systemic, auto-inflammatory responses resulting in significant health problems worldwide. In vivo information regarding the local and direct inflammatory effect of these dietary components in the intestine and, in particular, on the intestinal epithelium is lacking. Here we report that both mice and zebrafish exposed to high-fat (HFDs) or high-cholesterol (HCDs) diets develop acute innate inflammatory responses within hours, reflected in the localized interleukin-1β-dependent accumulation of myeloid cells in the intestine. Acute HCD-induced intestinal inflammation is dependent on cholesterol uptake via Niemann-Pick C1-like 1 and inflammasome activation involving apoptosis-associated Speck-like protein containing a caspase recruitment domain, which leads to Caspase-1 activity in intestinal epithelial cells. Extended exposure to HCD results in localized, inflammation-dependent, functional dysregulation as well as systemic pathologies. Our model suggests that dietary cholesterol initiates intestinal inflammation in epithelial cells.
Progatzky F, Sangha NJ, Yoshida N, et al., 2014, Intestinal inflammation induced by dietary cholesterol in Zebrafish, 9th European-Mucosal-Immunology-Group Meeting, Publisher: WILEY-BLACKWELL, Pages: 27-28, ISSN: 0019-2805
Liu Y-H, Tan KAL, Morrison IW, et al., 2013, Macrophage migration is controlled by Tribbles 1 through the interaction between C/EBP beta and TNF-alpha, VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, Vol: 155, Pages: 67-75, ISSN: 0165-2427
Peng J, Tsang JYS, Li D, et al., 2013, Inhibition of TGF-beta signaling in combination with TLR7 ligation re-programs a tumoricidal phenotype in tumor-associated macrophages, CANCER LETTERS, Vol: 331, Pages: 239-249, ISSN: 0304-3835
Taylor HB, Liepe J, Barthen C, et al., 2012, P38 and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish, Immunology and Cell Biology, Vol: 91, Pages: 60-69, ISSN: 1440-1711
The recruitment and migration of macrophages and neutrophils is an important process during the early stages of the innate immune system in response to acute injury. Transgenic pu.1:EGFP zebrafish permit the acquisition of leukocyte migration trajectories during inflammation. Currently, these high-quality live-imaging data are mainly analysed using general statistics, for example, cell velocity. Here, we present a spatio-temporal analysis of the cell dynamics using transition matrices, which provide information of the type of cell migration. We find evidence that leukocytes exhibit types of migratory behaviour, which differ from previously described random walk processes. Dimethyl sulfoxide treatment decreased the level of persistence at early time points after wounding and ablated temporal dependencies observed in untreated embryos. We then use pharmacological inhibition of p38 and c-Jun N-terminal kinase mitogen-activated protein kinases to determine their effects on in vivo leukocyte migration patterns and discuss how they modify the characteristics of the cell migration process. In particular, we find that their respective inhibition leads to decreased and increased levels of persistent motion in leukocytes following wounding. This example shows the high level of information content, which can be gained from live-imaging data if appropriate statistical tools are used.
Peng J, Li D, Chan YK, et al., 2012, Effects of water uptake on melamine renal stone formation in mice, NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol: 27, Pages: 2225-2231, ISSN: 0931-0509
Chen L, McGinty J, Taylor HB, et al., 2012, Incorporation of an experimentally determined MTF for spatial frequency filtering and deconvolution during optical projection tomography reconstruction, OPTICS EXPRESS, Vol: 20, Pages: 7323-7337, ISSN: 1094-4087
Liepe J, Taylor H, Barnes CP, et al., 2012, Calibrating spatio-temporal models of leukocyte dynamics against in vivo live-imaging data using approximate Bayesian computation, INTEGRATIVE BIOLOGY, Vol: 4, Pages: 335-345, ISSN: 1757-9694
Chen L, McGinty J, Taylor HB, et al., 2012, Improved OPT reconstructions based on the MTF and extension to FLIM-OPT
We demonstrate the improved reconstruction of OPT datasets by incorporating the measured MTF in the reconstruction process. We also extend OPT to FLIM-OPT and demonstrate its use for imaging live zebrafish embryos displaying autofluorescence. © 2012 OSA.
Chen Y, Li D, Tsang JYS, et al., 2011, PPAR-gamma signaling and IL-5 inhibition together prevent chronic rejection of MHC Class II mismatched cardiac grafts, JOURNAL OF HEART AND LUNG TRANSPLANTATION, Vol: 30, Pages: 698-706, ISSN: 1053-2498
Pridgeon C, Bugeon L, Donnelly L, et al., 2011, Regulation of IL-17 in chronic inflammation in the human lung., Clin Sci (Lond), Vol: 120, Pages: 515-524
The regulation of human Th17 cell effector function by Treg cells (regulatory T-cells) is poorly understood. In the present study, we report that human Treg (CD4(+)CD25(+)) cells inhibit the proliferative response of Th17 cells but not their capacity to secrete IL (interleukin)-17. However, they could inhibit proliferation and cytokine production by Th1 and Th2 cells as determined by IFN-γ (interferon-γ) and IL-5 biosynthesis. Currently, as there is interest in the role of IL-17-producing cells and Treg cells in chronic inflammatory diseases in humans, we investigated the presence of CD4(+)CD25(+) T-cells and IL-17 in inflammation in the human lung. Transcripts for IL-17 were expressed in mononuclear cells and purified T-cells from lung tissue of patients with chronic pulmonary inflammation and, when activated, these cells secrete soluble protein. The T-cell-specific transcription factors RORCv2 (retinoic acid-related orphan receptor Cv2; for Th17) and FOXP3 (forkhead box P3; for Treg cells) were enriched in the T-cell fraction of lung mononuclear cells. Retrospective stratification of the patient cohort into those with COPD (chronic obstructive pulmonary disease) and non-COPD lung disease revealed no difference in the expression of IL-17 and IL-23 receptor between the groups. We observed that CD4(+)CD25(+) T-cells were present in comparable numbers in COPD and non-COPD lung tissue and with no correlation between the presence of CD4(+)CD25(+) T-cells and IL-17-producing cells. These results suggest that IL-17-expressing cells are present in chronically inflamed lung tissue, but there is no evidence to support this is due to the recruitment or expansion of Treg cells.
McGinty J, Taylor HB, Chen L, et al., 2011, In vivo fluorescence lifetime optical projection tomography, Biomedical Optics Express, Vol: 2, Pages: 1340-1350, ISSN: 2156-7085
We demonstrate the application of fluorescence lifetime optical projection tomography (FLIM-OPT) to in vivo imaging of lysC:GFP transgenic zebrafish embryos (Danio rerio). This method has been applied to unambiguously distinguish between the fluorescent protein (GFP) signal in myeloid cells from background autofluorescence based on the fluorescence lifetime. The combination of FLIM, an inherently ratiometric method, in conjunction with OPT results in a quantitative 3-D tomographic technique that could be used as a robust method for in vivo biological and pharmaceutical research, for example as a readout of Förster resonance energy transfer based interactions.
Urbanowicz RA, Lamb JR, Todd I, et al., 2010, Enhanced effector function of cytotoxic cells in the induced sputum of COPD patients, RESPIRATORY RESEARCH, Vol: 11
Urbanowicz RA, Lamb JR, Todd I, et al., 2009, Altered effector function of peripheral cytotoxic cells in COPD, RESPIRATORY RESEARCH, Vol: 10, ISSN: 1465-993X
Lockhart A, Lamb JR, Osredkar T, et al., 2007, PIB is a non-specific imaging marker of amyloid-beta (A beta) peptide-related cerebral amyloidosis, BRAIN, Vol: 130, Pages: 2607-2615, ISSN: 0006-8950
Chen Y, Liu Y, Yuan Z, et al., 2007, Rosiglitazone suppresses cyclosporin-induced chronic transplant dysfunction and prolongs survival of rat cardiac allografts, TRANSPLANTATION, Vol: 83, Pages: 1602-1610, ISSN: 0041-1337
Chen Y, Li X, Tian L, et al., 2007, Inhibition of sonic hedgehog signaling reduces chronic rejection and prolongs allograft survival in a rat orthotopic small bowel transplantation model, TRANSPLANTATION, Vol: 83, Pages: 1351-1357, ISSN: 0041-1337
Carlin LM, Yanagi K, Verhoef A, et al., 2005, Secretion of IFN-gamma and not IL-2 by anergic human T cells correlates with assembly of an immature immune synapse, BLOOD, Vol: 106, Pages: 3874-3879, ISSN: 0006-4971
Dallman MJ, Smith E, Benson RA, et al., 2005, Notch: Control of lymphocyte differentiation in the periphery, CURRENT OPINION IN IMMUNOLOGY, Vol: 17, Pages: 259-266, ISSN: 0952-7915
Wong KK, Carpenter M, Young LL, et al., 2003, Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8(+) cell-dependent mechanism, JOURNAL OF CLINICAL INVESTIGATION, Vol: 112, Pages: 1741-1750, ISSN: 0021-9738
Faith A, Richards DF, Verhoef A, et al., 2003, Impaired secretion of interleukin-4 and interleukin-13 by allergen-specific T cells correlates with defective nuclear expression of NF-AT2 and jun B: relevance to immunotherapy, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 33, Pages: 1209-1215, ISSN: 0954-7894
Mckenzie GJ, Young LL, Briend E, et al., 2003, Notch signalling in the regulation of peripheral T-cell function, SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, Vol: 14, Pages: 127-134, ISSN: 1084-9521
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