Publications
165 results found
Iqbal MB, Johns M, Laffan MA, et al., 2010, Dexamethasone reduces monocyte thrombogenecity via tissue factor-dependent and tissue factor-independent pathways, Publisher: ELSEVIER IRELAND LTD, Pages: E6-E6, ISSN: 0021-9150
Sperone A, Dryden N, Birdsey GM, et al., 2010, The transcription factor Erg represses ICAM-1 expression and vascular inflammation, Publisher: ELSEVIER IRELAND LTD, Pages: E17-E17, ISSN: 0021-9150
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- Citations: 1
Stangou M, Bhangal G, Lai P-C, et al., 2010, Effect of IL-11 on glomerular expression of TGF-beta and extracellular matrix in nephrotoxic nephritis in Wistar Kyoto rats, JOURNAL OF NEPHROLOGY, Vol: 24, Pages: 106-111, ISSN: 1121-8428
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- Citations: 9
Gaemperli O, Boyle JJ, Rimoldi OE, et al., 2010, Molecular imaging of vascular inflammation, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol: 37, Pages: 1236-1236, ISSN: 1619-7070
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- Citations: 13
Abdul-Salam VB, Ramrakha P, Krishnan U, et al., 2010, Identification and Assessment of Plasma Lysozyme as a Putative Biomarker of Atherosclerosis, ARTERIOSCL THROM VAS, Vol: 30, Pages: 1027-U306, ISSN: 1079-5642
Keenan NG, Sheppard MN, Grasso A, et al., 2010, Validation of Carotid Arterial Wall Volume Measurement by Cardiovascular Magnetic Resonance, JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol: 31, Pages: 935-941, ISSN: 1053-1807
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- Citations: 5
Chan CF, Keenan NG, Nielles-Vallespin S, et al., 2010, Ultra-short echo time cardiovascular magnetic resonance of atherosclerotic carotid plaque, Journal of Cardiovascular Magnetic Resonance, Vol: 12, ISSN: 1097-6647
BackgroundMulti-contrast weighted cardiovascular magnetic resonance (CMR) allows detailed plaque characterisation and assessment of plaque vulnerability. The aim of this preliminary study was to show the potential of Ultra-short Echo Time (UTE) subtraction MR in detecting calcification.Methods14 ex-vivo human carotid arteries were scanned using CMR and CT, prior to histological slide preparation. Two images were acquired using a double-echo 3D UTE pulse, one with a long TE and the second with an ultra-short TE, with the same TR. An UTE subtraction (ΔUTE) image containing only ultra-short T2 (and T2*) signals was obtained by post-processing subtraction of the 2 UTE images. The ΔUTE image was compared to the conventional 3D T1-weighted sequence and CT scan of the carotid arteries.ResultsIn atheromatous carotid arteries, there was a 71% agreement between the high signal intensity areas on ΔUTE images and CT scan. The same areas were represented as low signal intensity on T1W and areas of void on histology, indicating focal calcification. However, in 15% of all the scans there were some incongruent regions of high intensity on ΔUTE that did not correspond with a high intensity signal on CT, and histology confirmed the absence of calcification.ConclusionsWe have demonstrated that the UTE sequence has potential to identify calcified plaque. Further work is needed to fully understand the UTE findings.
Ali F, Ali NS, Bauer A, et al., 2010, PPARδ and PGC1α act cooperatively to induce haem oxygenase-1 and enhance vascular endothelial cell resistance to stress, CARDIOVASCULAR RESEARCH, Vol: 85, Pages: 701-710, ISSN: 0008-6363
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- Citations: 49
Chaudhury H, Zakkar M, Boyle J, et al., 2010, c-Jun N-Terminal Kinase Primes Endothelial Cells at Atheroprone Sites for Apoptosis, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol: 30, Pages: 546-U393, ISSN: 1079-5642
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- Citations: 56
Boyle JJ, Leung VWY, Rizvi H, et al., 2009, MATRIX-BOUND AGGREGATED IGM DRIVES MACROPHAGE CYTOTOXICITY VIA MACROPHAGE SCAVENGER RECEPTOR A AND IS INCREASED IN RUPTURED PLAQUES, Spring Meeting of the British-Society-for-Cardiovascular-Research, Publisher: B M J PUBLISHING GROUP, ISSN: 1355-6037
Boyle JJ, Johns M, Mason JC, et al., 2009, MONOCYTE DIFFERENTIATION TO AN ATHEROPROTECTIVE PHENOTYPE EXPRESSING HEME OXYGENASE-1 PIVOTALLY REQUIRES A HEME-INDUCIBLE TRANS-ACTIVATING FACTOR AND IS COUNTERACTED BY THE NUCLEAR RECEPTOR REVERB, Spring Meeting of the British-Society-for-Cardiovascular-Research, Publisher: B M J PUBLISHING GROUP, ISSN: 1355-6037
Sperone A, Birdsey GM, Dryden N, et al., 2009, THE TRANSCRIPTION FACTOR ERG PREVENTS VASCULAR INFLAMMATION BY REPRESSING ICAM-1 EXPRESSION, Spring Meeting of the British-Society-for-Cardiovascular-Research, Publisher: B M J PUBLISHING GROUP, ISSN: 1355-6037
Chaudhury HA, Zakkar M, Boyle J, et al., 2009, ENDOTHELIAL CELLS AT ATHEROSUSCEPTIBLE SITES EXPRESS ACTIVATED C-JUN N-TERMINAL KINASE WHICH INDUCES PRO-APOPTOTIC MOLECULES, Spring Meeting of the British-Society-for-Cardiovascular-Research, Publisher: B M J PUBLISHING GROUP, ISSN: 1355-6037
Leung VWY, Yun S, Botto M, et al., 2009, Decay-Accelerating Factor Suppresses Complement C3 Activation and Retards Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice, AMERICAN JOURNAL OF PATHOLOGY, Vol: 175, Pages: 1757-1767, ISSN: 0002-9440
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- Citations: 37
Lewis MJ, Malik TH, Ehrenstein MR, et al., 2009, Immunoglobulin M Is Required for Protection Against Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice, CIRCULATION, Vol: 120, Pages: 417-U101, ISSN: 0009-7322
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- Citations: 192
ALI F, Zakkar M, Karu K, et al., 2009, Induction of the cytoprotective enzyme heme oxygenase-1 by statins is enhanced in vascular endothelium exposed to laminar shear stress and impaired by disturbed flow., Journal of Biological Chemistry
Boyle JJ, Harrington HA, Piper E, et al., 2009, Coronary Intraplaque Hemorrhage Evokes a Novel Atheroprotective Macrophage Phenotype, AMERICAN JOURNAL OF PATHOLOGY, Vol: 174, Pages: 1097-1108, ISSN: 0002-9440
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- Citations: 247
Lutz J, Luong LA, Strobl M, et al., 2008, The A20 gene protects kidneys from ischaemia/reperfusion injury by suppressing pro-inflammatory activation, JOURNAL OF MOLECULAR MEDICINE-JMM, Vol: 86, Pages: 1329-1339, ISSN: 0946-2716
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- Citations: 40
Yun S, Leung VWY, Botto M, et al., 2008, Brief report: Accelerated atherosclerosis in low-density lipoprotein receptor-deficient mice lacking the membrane-bound complement regulator CD59, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol: 28, Pages: 1714-1716, ISSN: 1079-5642
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- Citations: 34
Haskard DO, Boyle JJ, Mason JC, 2008, The role of complement in atherosclerosis, CURRENT OPINION IN LIPIDOLOGY, Vol: 19, Pages: 478-482, ISSN: 0957-9672
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- Citations: 62
Lewis MJ, Malik TH, Ehrenstein MR, et al., 2008, IgM deficiency accelerates atherosclerosis: A potential adverse consequence of B cell depletion therapy?, 72nd Annual Scientific Meeting of the American-College-of-Rheumatology/43rd Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals, Publisher: WILEY-LISS, Pages: S934-S934, ISSN: 0004-3591
Enesa K, Ito K, Luong LA, et al., 2008, Hydrogen peroxide prolongs nuclear localization of NF-κB in activated cells by suppressing negative regulatory mechanisms, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 283, Pages: 18582-18590
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- Citations: 56
Yeh JSM, Sennoga C, McConnell E, et al., 2008, Echo identification and quantification of inflammatory molecules in the heart, Annual Scientific Conference of the British-Cardiovascular-Society/British-Society-for-Cardiovascular-Research, Publisher: B M J PUBLISHING GROUP, Pages: A21-A22, ISSN: 1355-6037
Kinderlerer AR, Ali F, Johns M, et al., 2008, KLF2-dependent, shear stress-induced expression of CD59 - A novel cytoprotective mechanism against complement-mediated injury in the vasculature, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 283, Pages: 14636-14644, ISSN: 0021-9258
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- Citations: 43
Ali F, Kinderlerer AR, Johns M, et al., 2008, KLF-2-dependent, shear stress-induced expression of CD59: A novel cytoprotective mechanism against complement-mediated injury in the vasculature., Journal of Biological Chemistry, Vol: 283, Pages: 14636-44
Boyle JJ, Philippidis P, Horncastle D, et al., 2008, Atherosclerotic intralesional haemorrhage moulds monocyte differentiation into a macrophage antioxidant phenotype bearing the hemoglobin scavenger receptor CD163, Publisher: FEDERATION AMER SOC EXP BIOL, ISSN: 0892-6638
Yun S, Leung V, Botto M, et al., 2008, Accelerated Atherosclerosis in Low Density Lipoprotein Receptor Deficient mice lacking the membrane complement regulator CD59, Publisher: FEDERATION AMER SOC EXP BIOL, ISSN: 0892-6638
Leung VWY, Yun S, Mason J, et al., 2008, Decay-Accelerating Factor plays a critical atheroprotective role in Low Density Lipoprotein deficient (ldlr-/-) mice, Publisher: FEDERATION AMER SOC EXP BIOL, ISSN: 0892-6638
Leung V, Yun S, Mason J, et al., 2008, Decay-Accelerating Factor plays a critical atheroprotective role in Low Density Lipoprotein deficient (ldlr-/-) mice, Publisher: FEDERATION AMER SOC EXP BIOL, ISSN: 0892-6638
Lewis MJ, Malik TH, Ehrenstein MR, et al., 2008, Hierarchical contributions of IgM and complement C1q in protection against murine atherosclerosis, FASEB JOURNAL, Vol: 22, ISSN: 0892-6638
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- Citations: 1
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