Publications
165 results found
Summers SA, Dorling A, Boyle JJ, et al., 2005, Cure of disseminated cryptococcal infection in a renal allograft recipient after addition of γ-interferon to anti-fungal therapy, AMERICAN JOURNAL OF TRANSPLANTATION, Vol: 5, Pages: 2067-2069, ISSN: 1600-6135
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- Citations: 21
Brown M, Noursadeghi M, Boyle J, et al., 2005, Successful liposomal amphotericin B treatment of <i>Leishmania braziliensis</i> cutaneous leishmaniasis, BRITISH JOURNAL OF DERMATOLOGY, Vol: 153, Pages: 203-205, ISSN: 0007-0963
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- Citations: 55
Haskard DO, Bhatia V, Boyle JJ, et al., 2005, Role of complement and complement regulatory proteins in atherosclerosis, 75th Congress of the European-Atherosclerosis-Society, Publisher: ELSEVIER IRELAND LTD, Pages: 39-39, ISSN: 1567-5688
Yeh JS, Tracy S, Drescher KM, et al., 2005, Expression of E-selectin in coxsackievirus B3 myocarditis, 54th Annual Scientific Session of the American-College-of-Cardiology, Publisher: ELSEVIER SCIENCE INC, Pages: 142A-142A, ISSN: 0735-1097
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- Citations: 1
Boyle JJ, 2005, Macrophage activation in atherosclerosis: pathogenesis and pharmacology of plaque rupture., Curr Vasc Pharmacol, Vol: 3, Pages: 63-68, ISSN: 1570-1611
Atherosclerosis is still an important disease. It accounts for 39% of deaths in the U.K. and 12 million U.S citizens have atherosclerosis-associated disease. Atherosclerosis may exert clinical effects by slow narrowing, producing stable angina or dramatic rupture, producing acute coronary syndromes such as unstable angina or myocardial infarction and death. Macrophages are abundant in ruptured atherosclerotic plaques. Macrophages are innate immune effectors, i.e. they are activated without antigenic specificity. This may make them liable to indiscriminate tissue damage, since they are less selective than lymphocytes. Macrophages are recruited and activated by many signals and have an impressive armamentarium of molecules to promote tissue damage. Macrophage recruitment by abnormal endothelium over developing atherosclerotic plaques, is aided by endothelial expression of adhesion molecules (ICAM-1, VCAM, ELAM). Use of knockout mice has implicated the chemoattractant cytokine (chemokine) MCP-1 in attracting macrophage recruitment in atherosclerosis. Macrophage-activation stimuli associated with atherosclerotic risk factors include oxidised low density lipoprotein (oxLDL, "bad cholesterol"), advanced glycosylation end products (AGEs) of diabetes, angiotensin II and endothelin. Substantial work has clarified macrophage activation by OxLDL via macrophage scavenger receptors (MSRs), especially MSRA and CD36. Activated macrophages express effector molecules that kill cells and degrade extracellular matrix. These include Fas-L and nitric oxide (NO). Macrophage NO is derived from the high output inducible nitric oxide synthase (iNOS) pathway and upregulates vascular smooth muscle (VSMC) cell surface Fas, priming them for apoptosis. Activated macrophages express surface Fas-L, similar to cytotoxic T-lymphocytes and natural killer cells. Since VSMCs promote plaque stability, VSMC apoptosis may promote plaque rupture. Macrophages express multiple metalloproteinases (e
Elkington PT, Emerson JE, Lopez-Pascua LD, et al., 2005, <i>Mycobacterium tuberculosis</i>-infected monocytes drive a matrix degrading phenotype in pulmonary epithelial cells via a p38 switch, 38th Annual Meeting of the Society-for-Leukocyte-Biology, Publisher: FEDERATION AMER SOC EXP BIOL, Pages: 62-63, ISSN: 0741-5400
Landis C, Philippidis P, Boyle JJ, et al., 2005, Hemoglobin scavenging (CD163+) macrophages in atherosclerosis: an anti-inflammatory checkpoint?, 38th Annual Meeting of the Society-for-Leukocyte-Biology, Publisher: FEDERATION AMER SOC EXP BIOL, Pages: 41-41, ISSN: 0741-5400
Elkington PTG, O'Kane CM, Boyle JJ, et al., 2004, Mechanisms regulating matrix metalloproteinase gene expression and secretion in pulmonary tuberculosis, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: 2-2, ISSN: 0040-6376
Haywood MEK, Rogers NJ, Rose SJ, et al., 2004, Dissection of BXSB lupus phenotype using mice congenic for chromosome 1 demonstrates that separate intervals direct different aspects of disease, JOURNAL OF IMMUNOLOGY, Vol: 173, Pages: 4277-4285, ISSN: 0022-1767
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- Citations: 39
Lee NJ, Rigby RJ, Gill H, et al., 2004, Multiple loci are linked with anti-red blood cell antibody production in NZB mice -- comparison with other phenotypes implies complex modes of action., Clin Exp Immunol, Vol: 138, Pages: 39-46
Boyle JJ, 2004, Human macrophages kill human mesangial cells by Fas-L-induced apoptosis when triggered by antibody via CD16, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 137, Pages: 529-537, ISSN: 0009-9104
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- Citations: 18
Rigby RJ, Rozzo SJ, Boyle JJ, et al., 2004, New loci from New Zealand Black and New Zealand White on chromosomes 4 and 12 contribute to lupus-like disease in the context of BALB/c, JOURNAL OF IMMUNOLOGY, Vol: 172, Pages: 4609-4617, ISSN: 0022-1767
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- Citations: 21
Haywood MEK, Rose J, Boyle J, et al., 2004, GENETIC DISSECTION OF BXSB LUPUS PHENOTYPE USING MICE CONGENIC FOR CHROMOSOME 1 DEMONSTRATES THAT SEPARATE INTERVALS DIRECT DIFFERENT ASPECTS OF DISEASE, RHEUMATOLOGY, Vol: 43, Pages: 24-24, ISSN: 1462-0324
Barakat MT, Ashrafian H, Todd JF, et al., 2004, Renal magnesium loss causing hypomagnesaemia and autonomous hyperparathyroidism, NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol: 19, Pages: 977-980, ISSN: 0931-0509
FitzGerald AJ, Pu M, Marckbank T, et al., 2004, Synergistic effects of systemic trefoil factor family 1 and epidermal growth factor in a rat model of colitis, Annual Meeting of the British-Society-of-Gastroenterology, Publisher: B M J PUBLISHING GROUP, Pages: A96-A96, ISSN: 0017-5749
Elkington PTG, Nutall RK, Boyle JJ, et al., 2004, <i>Mycobacterium tuberculosis</i> (MTb) stimulates matrix metalloproteinase-1 and-7 expression in human monocytic cells regulated by divergent mechanisms, 37th Annual Meeting of the Society-for-Leukocyte-Biology, Publisher: FEDERATION AMER SOC EXP BIOL, Pages: 40-40, ISSN: 0741-5400
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- Citations: 1
Fitzgerald AJ, Pu M, Marchbank T, et al., 2004, Synergistic effects of systemic trefoil factor family 1 (TFF1) peptide and epidermal growth factor in a rat model of colitis., Peptides, Vol: 25, Pages: 793-801
Cooke FJ, Terpos E, Boyle J, et al., 2003, Disseminated <i>Aspergillus terreus</i> infection arising from cutaneous inoculation treated with caspofungin, CLINICAL MICROBIOLOGY AND INFECTION, Vol: 9, Pages: 1238-1241, ISSN: 1198-743X
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- Citations: 14
Sullivan DC, Huminiecki L, Moore JW, et al., 2003, EndoPDI, a novel protein-disulfide isomerase-like protein that is preferentially expressed in endothelial cells acts as a stress survival factor, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 278, Pages: 47079-47088, ISSN: 0021-9258
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- Citations: 143
Boyle JJ, Weissberg PL, Bennett MR, 2003, Tumor necrosis factor-α promotes macrophage-induced vascular smooth muscle cell apoptosis by direct and autocrine mechanisms, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol: 23, Pages: 1553-1558, ISSN: 1079-5642
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- Citations: 148
Bhatia VK, Boyle JJ, Roberts CE, et al., 2003, Influence of complement C1Q deficiency on early lesion formation in LDL receptor knock-out mice, Joint Meeting of the British-Atherosclerosis-Society/British-Society-for-Haemostasis-and-Thrombosis, Publisher: ELSEVIER SCI IRELAND LTD, Pages: S3-S3, ISSN: 0021-9150
Charakida A, Seaton ED, Boyle JJ, et al., 2003, A novel case of primary metaplastic carcinoma of the skin, 83rd Annual Meeting of the British Association of Dermatologists, Publisher: BLACKWELL PUBLISHING LTD, Pages: 16-16, ISSN: 0007-0963
Boyle J, 2003, Histological measurement of tumour angiogenesis, EUROPEAN JOURNAL OF CANCER, Vol: 39, Pages: 859-860, ISSN: 0959-8049
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- Citations: 4
FitzGerald AJ, Marchbank T, Boyle J, et al., 2003, The nutriceutical bovine colostrum for the treatment of dextran sulfate sodium induced colitis in rats, Annual meeting of the British-Society-of-Gastroenterology, Publisher: BRITISH MED JOURNAL PUBL GROUP, Pages: A64-A64, ISSN: 0017-5749
Soilleux EJ, Morris LS, Trowsdale J, et al., 2002, Human atherosclerotic plaques express DC-SIGN, a novel protein found on dendritic cells and macrophages, JOURNAL OF PATHOLOGY, Vol: 198, Pages: 511-516, ISSN: 0022-3417
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- Citations: 42
Boyle JJ, Weissberg PL, Bennett MR, 2002, Human macrophage-induced vascular smooth muscle cell apoptosis requires NO enhancement of Fas/Fas-L interactions, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol: 22, Pages: 1624-1630, ISSN: 1079-5642
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- Citations: 85
Boyle JJ, 2002, A non-isotopic fluorescence microscopy assay-for human macrophage-mesangial cell ADCC identifies Fc-γ -RIII, phospholipase C and Fas-L mediated apoptosis., JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Vol: 13, Pages: 97A-97A, ISSN: 1046-6673
Boyle JJ, Smith J, Pusey CD, et al., 2002, Susceptibility of WKY rats to glomerulonephritis is associated with enhanced macrophage killing of mesangial cells mediated via nitric oxide and phospholipase C., JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Vol: 13, Pages: 49A-49A, ISSN: 1046-6673
Berlanga J, Prats P, Remirez D, et al., 2002, Prophylactic use of epidermal growth factor reduces ischemia/reperfusion intestinal damage, AMERICAN JOURNAL OF PATHOLOGY, Vol: 161, Pages: 373-379, ISSN: 0002-9440
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- Citations: 63
Boyle JJ, Bowyer DE, Weissberg PL, et al., 2001, Human blood-derived macrophages induce apoptosis in human plaque-derived vascular smooth muscle cells by Fass-ligand/Fas interactions, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol: 21, Pages: 1402-1407, ISSN: 1079-5642
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- Citations: 115
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