Imperial College London
Alternate

Dr Joseph J Boyle

Faculty of Medicine, National Heart & Lung Institute

Clinical Reader in Vascular Molecular Pathology
 
 
 
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Contact

 

+44 (0)20 7594 2723joseph.boyle Website

 
 
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Location

 

L536ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Koskeridis:2022:10.1038/s41467-022-34688-6,
author = {Koskeridis, F and Evangelou, E and Said, S and Boyle, J and Elliott, P and Dehghan, A and Tzoulaki, I},
doi = {10.1038/s41467-022-34688-6},
journal = {Nature Communications},
title = {Pleiotropic genetic architecture and novel loci for C-reactive protein levels},
url = {http://dx.doi.org/10.1038/s41467-022-34688-6},
volume = {13},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - C-reactive protein is involved in a plethora of pathophysiological conditions. Many genetic loci associated with C-reactive protein are annotated to lipid and glucose metabolism genes supporting common biological pathways between inflammation and metabolic traits. To identify novel pleiotropic loci, we perform multi-trait analysis of genome-wide association studies on C-reactive protein levels along with cardiometabolic traits, followed by a series of in silico analyses including colocalization, phenome-wide association studies and Mendelian randomization. We find 41 novel loci and 19 gene sets associated with C-reactive protein with various pleiotropic effects. Additionally, 41 variants colocalize between C-reactive protein and cardiometabolic risk factors and 12 of them display unexpected discordant effects between the shared traits which are translated into discordant associations with clinical outcomes in subsequent phenome-wide association studies. Our findings provide insights into shared mechanisms underlying inflammation and lipid metabolism, representing potential preventive and therapeutic targets.
AU  - Koskeridis,F
AU  - Evangelou,E
AU  - Said,S
AU  - Boyle,J
AU  - Elliott,P
AU  - Dehghan,A
AU  - Tzoulaki,I
DO  - 10.1038/s41467-022-34688-6
PY  - 2022///
SN  - 2041-1723
TI  - Pleiotropic genetic architecture and novel loci for C-reactive protein levels
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-022-34688-6
UR  - http://hdl.handle.net/10044/1/101538
VL  - 13
ER  -
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