Imperial College London

Dr Joseph J Boyle

Faculty of MedicineNational Heart & Lung Institute

Clinical Reader in Vascular Molecular Pathology



+44 (0)20 7594 2723joseph.boyle Website




L536ICTEM buildingHammersmith Campus





Control of inflammation by re-instructing macrophages

Macrophages are a major type of inflammatory cell. They play a key role in atherosclerosis, which causes heart attacks and strokes. They are also major players in airways and lung disease, vasculitis and renal inflammation. They contribute to tissue destruction in inflammation.

But, macrophages are also normal tissue components and are numerous in key organs such as the spleen. In the spleen, they play a key role in recycling iron from old red blood cells. They contribute to maintenance of normal tissues.

In the end-phase of inflammation, macrophages play a role in tissue restitution by promoting regrowth and eating and recycling tissue debris and removing inflammatory mediators.

So what makes macrophages do very different things in different circumstances ?

One of the key differences is the set of genes that are switched on and off.

Our goal is to understand and find new ways to alter macrophage gene expression. This will allow drugs to reduce inflammation via the new mechanism of 're-polarizing' tissue-damaging macrophages into pro-resolution macrophages.


Guido de Meyer, Univ. Antwerp, Role of Atf1 in intraplaque hemorrhage in mice, 2018

Anna Randi, Imperial College London, Transcriptional control in inflammation, 2017

Claudio Raimondi, Imperial College London, Iron and inflammation, 2017 - 2027

Derek Gilroy, University College London, Anti-inflammatory pharmacology, 2017 - 2027

Graeme Birdsey, Imperial College London, Transcriptional control in inflammation, 2017 - 2027

Sian Harding, Imperial College London, Macrophage regulation of regeneration, 2017 - 2027

Prakash Punjabi, Imperial College London, Inflammation in heart failure, 2017

Niall Dillon, Imperial College London (MRC LMS), Gene regulation by chromatin modification, 2017 - 2022

Jan Nilsson, Isabel Goncalves, Universities of Malmo and Lund, Macrophage regulation in atherosclerosis, 2017 - 2027

Mat Daemen, AMC Amsterdam, Macrophages in atherosclerosis pathology, 2016 - 2027

Gillian Gray, University of Edinburgh, Macrophage regulation of myocardial ischemia-reperfusion damage, 2016 - 2027

James Leiper, University of Glasgow, Gene regulation by nitric oxide and cyclic-guanosine monophosphate, 2015 - 2020

Guido de Meyer, University of Antwerp, Macrophage regulation in atherosclerosis, 2014 - 2027

Nick Long, Imperial College London, Chemical biology of vascular inflammation, 2014 - 2027

Soren Moestrup, University of Aarhus, CD163, 2014 - 2027

Jorge Ferrer, Imperial College London, Genomics and gene regulation, 2014 - 2027

Mark Mercola, Pilar Luiz-Luzano, Stanford University, Cardiovascular pathology, 2012 - 2016

Prof Bart Staels, Institut Pasteur, University of Lille, INSERM 1011, Transcriptional regulation of macrophages in atherosclerosis, 2012

Ramzi Khamis, Imperial College London, Athersclerosis, 2011 - 2027

David Carling, Imperial college London, AMPK in macrophages, 2009 - 2027

Dominik Schaer, Zurich University Hospital / ETH Zurich, Macrophages, hemoglobin and anti-inflammatory approaches, 2008 - 2027

Prof Justin C Mason, Imperial College London, Heme oxygenase, anti-inflammatory mechanisms, vascular inflammation, vasculitis management and diagnosis, 2004 - 2027

James Scott, Imperial College London, Neuroinflammation

Claire Shovlin, Imperial college London, Iron and inflammation

Guest Lectures

Mhem macrophages in atherosclerosis: pathology to pharmacology and on to new cell biology. Nilsson Lab, University of Lund / Malmo, Sweden Feb 2017, University of Lund, Lund / Malmo, 2017

Mhem macrophages in atherosclerosis: pathology to pharmacology and epigenetic signalling. Novartis Institute of Biomedical Research, Basel, Oct 25, 2016, Novartis Institute of Biomedical Research, Basel, 2016

Hemorrhage and atherosclerosis: pathogenesis and imaging. Vulnerable Plaque Meeting. Reykjavik, June 25-30, 2016, Vulnerable Plaque Group, Reykjavik, 2016

Mhem macrophages in atherosclerosis: from cause to cure, University of Aberdeen, Aberdeen, 2015

Mhem macrophages in atherosclerosis: from pathogenesis to prevention. University of Sheffield, Sep 22-23, 2014, University of Sheffield,, Sheffield, 2014

Tenovus Medal Lecture for outstanding biomedical science, University of Glasgow, 2014, University of Glasgow, University of Glasgow, 2014

John French Lecture (given to younger scientist of exceptional promise), British Atherosclerosis Society 2014, British Atherosclerosis Society, Manchester Central, Manchester, 2014

An AMPK-ATF1 pathway drives Mhem atheroprotective macrophages, University of Edinburgh, Edinburgh, 2013

From intraplaque hemorrhage histology to metformin repurposing: the AMPK-ATF1-Mhem pathway of macrophage atheroprotection, Novartis NIBR, Basel, 2013

ATF1 drives atheroprotective macrophages., London Vascular Biology Forum, London, 2012

ATF1 coregulation of HO-1 and LXR defines an atheroprotective coregulatorypathway and corresponding Mhem plaque macrophage phenotype., Univ. of Lille/ Institut Pasteur / INSERM U1011 Aug 2012., Institut Pasteur, Lille, 2012

Atheroprotective macrophage subset defined by CD163., Session on macrophages inatherosclerosis. American Heart Association Scientific Sessions., Chicago, 2010

A novel atheroprotective macrophage phenotype., 5th European Vascular Biology andMedicine meeting (EVBM 2009) Organisation, Marseilles, 2009

Macrophage subsets in atherosclerosis, University of Reading, Reading, 2007

Macrophage smooth muscle cell interactions in atherosclerosis, The British Atherosclerosis Society, Oxford University, 2006

Macrophage-vascular smooth muscle cell interactions, Weill Medical School, Cornell University,, Manhattan, USA, 2001

Macrophages provoke killing of vascular smooth muscle cells, European Society for Cardiology, Stockholm, 2001

Apoptosis in Cardiovascular Disease, The Histochemical Society, 2000

CD163 defines a macrophage subset in coronary atherosclerosis,, Symposium on biology and medicine of CD163, Aarhus, Denmark, 2010