In order to find out more about my research activities or to find out about openings, please visit my group website: http://www3.imperial.ac.uk/edelgroup
Joshua's research publications can be found at the tab above, or on GoogleScholar.
Analytical Sensors plays a crucial role in today’s highly demanding exploration and development of new detection strategies. Whether it be medicine, biochemistry, bioengineering, or analytical chemistry the goals are essentially the same: 1) improve selectivity & sensitivity, 2) maximize throughput, 3) and reduce the instrumental footprint. In order to address these key challenges, the analytical community has borrowed technologies and design philosophies which has been used by the semiconductor industry over the past 20 years. By doing so, key technological advances have been made which include the miniaturization of sensors and signal processing components which allows for the efficient detection of nanoscale object. One can imagine that by decreasing the dimensions of a sensor to a scale similar to that of a nanoscale object, the ultimate in sensitivity can potentially be achieved - the detection of single molecules.
Research activities within the Edel group runs at the interface between chemistry, chemical biology, physics, and medicine in order to improve and develop new classes of sensors based on these principles. As such expertise within our group includes an array of techniques and methods which includes micro and nanofabrication, material processing, surface modification chemistries, semiconductor processing and characterization techniques, confocal microscopy, plasmonics, surface enhanced Raman spectroscopy, and single molecule techniques using both optical and electrical methods.
Prof. Joshua Edel received his PhD on the development of single molecule detection within microfluidic systems at Imperial College London in 2003. He then performed postdoctoral research in nanobiotechnology at Cornell University within the School of Applied and Engineering Physics. In 2005 he was awarded a research fellowship in single molecule biophysics at the Rowland Institute at Harvard University. In July 2006 he joined Imperial College London within the Department of Chemistry and Institute of Biomedical Engineering as a lecturer. Joshua is currently a Professor in the Department of Chemistry and in 2011 he was awarded a prestigious ERC Starting Grant on “Nanoporous Membranes for High Throughput Rare Event Bioanalysis” and in 2016 he was awarded an ERC Consolidator Grant related to the development of selective single molecule biosensors.
et al., 2017, Single Molecule Trapping and Sensing Using Dual Nanopores Separated by a Zeptoliter Nanobridge., Nano Letters, ISSN:1530-6984
et al., 2017, Low-noise Plasmonic Nanopore Biosensors for Single Molecule Detection at Elevated Temperatures, Acs Photonics, ISSN:2330-4022
et al., 2017, Quantitative Affinity Determination by Fluorescence Anisotropy Measurements of Individual Nanoliter Droplets, Analytical Chemistry, Vol:89, ISSN:0003-2700, Pages:1092-1101
et al., 2017, 3D Confocal Raman Tomography to Probe Field Enhancements inside Supercluster Metamaterials, Acs Photonics, Vol:4, ISSN:2330-4022, Pages:2070-2077
Lin X, Ivanov AP, Edel JB, 2017, Selective single molecule nanopore sensing of proteins using DNA aptamer-functionalised gold nanoparticles, Chemical Science, Vol:8, ISSN:2041-6520, Pages:3905-3912