Imperial College London
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Professor Joshua B. Edel

Faculty of Natural Sciences, Department of Chemistry

Professor of Biosensing & Analytical Sciences
 
 
 
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Contact

 

+44 (0)20 7594 0754joshua.edel Website

 
 
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Assistant

 

Mr John Murrell +44 (0)20 7594 2845

 
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Location

 

110cMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Tang:2021:10.1038/s41467-021-21101-x,
author = {Tang, L and Paulose, Nadappuram B and Cadinu, P and Zhao, Z and Xue, L and Yi, L and Ren, R and Wang, J and Ivanov, A and Edel, J},
doi = {10.1038/s41467-021-21101-x},
journal = {Nature Communications},
pages = {1--8},
title = {Combined quantum tunnelling and dielectrophoretic trapping for molecular analysis at ultra-low analyte concentrations},
url = {http://dx.doi.org/10.1038/s41467-021-21101-x},
volume = {12},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Quantum tunnelling offers a unique opportunity to study nanoscale objects with atomic resolution using electrical readout. However, practical implementation is impeded by the lack of simple, stable probes, that are required for successful operation. Existing platforms offer low throughput and operate in a limited range of analyte concentrations, as there is no active control to transport molecules to the sensor. We report on a standalone tunnelling probe based on double-barrelled capillary nanoelectrodes that do not require a conductive substrate to operate unlike other techniques, such as scanning tunnelling microscopy. These probes can be used to efficiently operate in solution environments and detect single molecules, including mononucleotides, oligonucleotides, and proteins. The probes are simple to fabricate, exhibit remarkable stability, and can be combined with dielectrophoretic trapping, enabling active analyte transport to the tunnelling sensor. The latter allows for up to 5-orders of magnitude increase in event detection rates and sub-femtomolar sensitivity.
AU  - Tang,L
AU  - Paulose,Nadappuram B
AU  - Cadinu,P
AU  - Zhao,Z
AU  - Xue,L
AU  - Yi,L
AU  - Ren,R
AU  - Wang,J
AU  - Ivanov,A
AU  - Edel,J
DO  - 10.1038/s41467-021-21101-x
EP  - 8
PY  - 2021///
SN  - 2041-1723
SP  - 1
TI  - Combined quantum tunnelling and dielectrophoretic trapping for molecular analysis at ultra-low analyte concentrations
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-021-21101-x
UR  - https://www.nature.com/articles/s41467-021-21101-x
UR  - http://hdl.handle.net/10044/1/86548
VL  - 12
ER  -
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