My research is focused on the molecular mechanisms conferring Carbapenem resistance in Klebsiella pneumoniae and how these changes influence pathogen virulence.
Klebsiella pneumoniae is a WHO Class 1 priority pathogen as it has acquired antimicrobial resistance to many last line antibiotics agents, such as Carbapenems. It is a common cause of hospital-acquired infections such as pneumonia, urinary tract infections and septicaemia. Carbapenem resistance renders this fundamentally important group of antibiotics ineffective and results in increased mortality for patients suffering from these infections.
I am a speciality trainee (ST6) in Intensive Care Medicine. Having completed Academic Foundation training I came to Professor Gad Frankel’s laboratory (MRC Centre for Molecular Bacteriology, Department of Life Sciences) on an NIHR Academic Clinical Fellowship (2015-2018). In 2019, I was awarded an MRC Clinical Research Training Fellowship to continue this work in the Frankel lab. My PhD is co-supervised by Professor Stephen Brett and Dr Abigail Clements. The project investigates the interaction between bacterial factors (outer membrane porins) contributing to Carbapenem resistance and in vivo virulence using novel translational pneumonia models.
et al., 2019, OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo, Nature Communications, Vol:10, ISSN:2041-1723
et al., 2018, Are large randomized controlled trials in severe sepsis and septic shock statistically disadvantaged by repeated inadvertent underestimates of required sample size, Bmj Open, Vol:8, ISSN:2044-6055
et al., 2017, Citrobacter rodentium relies on commensals for colonization of the colonic mucosa, Cell Reports, Vol:21, ISSN:2211-1247, Pages:3381-3389