Imperial College London
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DrJuliaSanchez Garrido

Faculty of Natural Sciences, Department of Life Sciences

Research Laboratory Manager
 
 
 
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Contact

 

julia.sanchez-garrido08

 
 
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Location

 

1.40Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sanchez:2021:10.1016/j.mib.2021.08.008,
author = {Sanchez, Garrido J and Alberdi, L and Chatterjee, S and Frankel, G and Mullineaux-Sanders, C},
doi = {10.1016/j.mib.2021.08.008},
journal = {Current Opinion in Microbiology},
pages = {19--26},
title = {Type III secretion system effector subnetworks elicit distinct host immune responses to infection},
url = {http://dx.doi.org/10.1016/j.mib.2021.08.008},
volume = {64},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Citrobacter  rodentium, a  natural  mouse  pathogen  which  colonises the  colon of immuno-competent  mice, provides a robust  model for  interrogating  host-pathogen-microbiota interactions in vivo. This  model  has  been  key  to  providing new insights  into local host responses to   enteric   infection, including   changes inintestinal epithelial cell immuno metabolism and mucosal immunity. C.  rodent iuminjects 31 bacterial effectors into epithelial cells via a type III secretion system (T3SS). Recently, these effectors were shown to be  able  to form multiple  intracellular  subnetworks  which can  withstand significant contractions whilst  maintaining  virulence. Here  we highlight recent advances in understanding gut mucosal responses to infection and effector biology, as well as potential uses for artificial intelligence (AI) in understanding infectious diseaseand speculate on the role of T3SS effector networks in host adaption.
AU  - Sanchez,Garrido J
AU  - Alberdi,L
AU  - Chatterjee,S
AU  - Frankel,G
AU  - Mullineaux-Sanders,C
DO  - 10.1016/j.mib.2021.08.008
EP  - 26
PY  - 2021///
SN  - 1369-5274
SP  - 19
TI  - Type III secretion system effector subnetworks elicit distinct host immune responses to infection
T2  - Current Opinion in Microbiology
UR  - http://dx.doi.org/10.1016/j.mib.2021.08.008
UR  - http://hdl.handle.net/10044/1/91777
VL  - 64
ER  -
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