Imperial College London
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ProfessorJulianGriffin

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 3220julian.griffin

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Imanikia:2019:10.1016/j.celrep.2019.06.057,
author = {Imanikia, S and Sheng, M and Castro, C and Griffin, JL and Taylor, RC},
doi = {10.1016/j.celrep.2019.06.057},
journal = {Cell Reports},
pages = {581--589.e4},
title = {XBP-1 remodels lipid metabolism to extend longevity},
url = {http://dx.doi.org/10.1016/j.celrep.2019.06.057},
volume = {28},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The endoplasmic reticulum unfolded protein response (UPRER) is a cellular stress response that maintains homeostasis within the secretory pathway, regulates glucose and lipid metabolism, and influences longevity. To ask whether this role in lifespan determination depends upon metabolic intermediaries, we metabotyped C. elegans expressing the active form of the UPRER transcription factor XBP-1, XBP-1s, and found many metabolic changes. These included reduced levels of triglycerides and increased levels of oleic acid (OA), a monounsaturated fatty acid associated with lifespan extension in C. elegans. Here, we show that constitutive XBP-1s expression increases the activity of lysosomal lipases and upregulates transcription of the Δ9 desaturase FAT-6, which is required for the full lifespan extension induced by XBP-1s. Dietary OA supplementation increases the lifespan of wild-type, but not xbp-1s-expressing animals and enhances proteostasis. These results suggest that modulation of lipid metabolism by XBP-1s contributes to its downstream effects on protein homeostasis and longevity.
AU  - Imanikia,S
AU  - Sheng,M
AU  - Castro,C
AU  - Griffin,JL
AU  - Taylor,RC
DO  - 10.1016/j.celrep.2019.06.057
EP  - 589
PY  - 2019///
SN  - 2211-1247
SP  - 581
TI  - XBP-1 remodels lipid metabolism to extend longevity
T2  - Cell Reports
UR  - http://dx.doi.org/10.1016/j.celrep.2019.06.057
UR  - https://www.sciencedirect.com/science/article/pii/S2211124719308307?via%3Dihub
UR  - http://hdl.handle.net/10044/1/72154
VL  - 28
ER  -
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