Imperial College London
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ProfessorJulianGriffin

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 3220julian.griffin

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{McMurran:2019:10.1073/pnas.1905787116,
author = {McMurran, CE and Guzman, de la Fuente A and Penalva, R and Ben, Menachem-Zidon O and Dombrowski, Y and Falconer, J and Gonzalez, GA and Zhao, C and Krause, FN and Young, AMH and Griffin, JL and Jones, CA and Hollins, C and Heimesaat, MM and Fitzgerald, DC and Franklin, RJM},
doi = {10.1073/pnas.1905787116},
journal = {Proceedings of the National Academy of Sciences},
pages = {25311--25321},
title = {The microbiota regulates murine inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remyelination},
url = {http://dx.doi.org/10.1073/pnas.1905787116},
volume = {116},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The microbiota is now recognized as a key influence on the host immune response in the central nervous system (CNS). As such, there has been some progress toward therapies that modulate the microbiota with the aim of limiting immune-mediated demyelination, as occurs in multiple sclerosis. However, remyelination—the regeneration of myelin sheaths—also depends upon an immune response, and the effects that such interventions might have on remyelination have not yet been explored. Here, we show that the inflammatory response during CNS remyelination in mice is modulated by antibiotic or probiotic treatment, as well as in germ-free mice. We also explore the effect of these changes on oligodendrocyte progenitor cell differentiation, which is inhibited by antibiotics but unaffected by our other interventions. These results reveal that high combined doses of oral antibiotics impair oligodendrocyte progenitor cell responses during remyelination and further our understanding of how mammalian regeneration relates to the microbiota.
AU  - McMurran,CE
AU  - Guzman,de la Fuente A
AU  - Penalva,R
AU  - Ben,Menachem-Zidon O
AU  - Dombrowski,Y
AU  - Falconer,J
AU  - Gonzalez,GA
AU  - Zhao,C
AU  - Krause,FN
AU  - Young,AMH
AU  - Griffin,JL
AU  - Jones,CA
AU  - Hollins,C
AU  - Heimesaat,MM
AU  - Fitzgerald,DC
AU  - Franklin,RJM
DO  - 10.1073/pnas.1905787116
EP  - 25321
PY  - 2019///
SN  - 0027-8424
SP  - 25311
TI  - The microbiota regulates murine inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remyelination
T2  - Proceedings of the National Academy of Sciences
UR  - http://dx.doi.org/10.1073/pnas.1905787116
UR  - https://www.pnas.org/content/early/2019/11/15/1905787116
UR  - http://hdl.handle.net/10044/1/75251
VL  - 116
ER  -
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