Imperial College London
Portrait Picture

ProfessorJulianGriffin

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
//

Contact

 

+44 (0)20 7594 3220julian.griffin

 
 
//

Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Gallagher:2021:ecco-jcc/jjaa227,
author = {Gallagher, K and Catesson, A and Griffin, JL and Holmes, E and Williams, HRT},
doi = {ecco-jcc/jjaa227},
journal = {Journal of Crohns & Colitis},
pages = {813--826},
title = {Metabolomic analysis in inflammatory bowel disease: a systematic review},
url = {http://dx.doi.org/10.1093/ecco-jcc/jjaa227},
volume = {15},
year = {2021}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND AND AIMS: The inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis, are chronic, idiopathic gastrointestinal (GI) diseases. Whilst their precise etiology is unknown, it is thought to involve a complex interaction between genetic predisposition and an abnormal host immune response to environmental exposures, likely microbial. Microbial dysbiosis has frequently been documented in IBD. Metabolomics (the study of small molecular intermediates and end products of metabolism in biological samples) provides a unique opportunity to characterize disease-associated metabolic changes and may be of particular use in quantifying gut microbial metabolism. Numerous metabolomic studies have been undertaken in inflammatory bowel disease populations, identifying consistent alterations in a range of molecules across several biological matrices. This systematic review aims to summarize these findings. METHODS: A comprehensive, systematic search was carried out using Medline and EMBASE. All studies were reviewed by two authors independently using predefined exclusion criteria. A total of sixty-four relevant papers were quality assessed and included in the review. RESULTS: Consistent metabolic perturbations were identified, including increases in levels of branched chain amino acids and lipid classes across stool, serum, plasma and tissue biopsy samples, and reduced levels of microbially modified metabolites in both urine (such as hippurate) and stool (such as secondary bile acids). CONCLUSIONS: This review provides a summary of metabolomic research in IBD to date, highlighting underlying themes of perturbed gut microbial metabolism and mammalian-microbial co-metabolism associated with disease status.
AU  - Gallagher,K
AU  - Catesson,A
AU  - Griffin,JL
AU  - Holmes,E
AU  - Williams,HRT
DO  - ecco-jcc/jjaa227
EP  - 826
PY  - 2021///
SN  - 1873-9946
SP  - 813
TI  - Metabolomic analysis in inflammatory bowel disease: a systematic review
T2  - Journal of Crohns & Colitis
UR  - http://dx.doi.org/10.1093/ecco-jcc/jjaa227
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33175138
UR  - https://academic.oup.com/ecco-jcc/article/15/5/813/5974408
UR  - http://hdl.handle.net/10044/1/85803
VL  - 15
ER  -
Download