Imperial College London
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ProfessorJulianGriffin

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 3220julian.griffin

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Timm:2020:10.1038/s42003-020-01440-z,
author = {Timm, KN and Perera, C and Ball, V and Henry, JA and Miller, JJ and Kerr, M and West, JA and Sharma, E and Broxholme, J and Logan, A and Savic, D and Dodd, MS and Griffin, JL and Murphy, MP and Heather, LC and Tyler, DJ},
doi = {10.1038/s42003-020-01440-z},
journal = {Commun Biol},
title = {Early detection of doxorubicin-induced cardiotoxicity in rats by its cardiac metabolic signature assessed with hyperpolarized MRI.},
url = {http://dx.doi.org/10.1038/s42003-020-01440-z},
volume = {3},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Doxorubicin (DOX) is a widely used chemotherapeutic agent that can cause serious cardiotoxic side effects culminating in congestive heart failure (HF). There are currently no clinical imaging techniques or biomarkers available to detect DOX-cardiotoxicity before functional decline. Mitochondrial dysfunction is thought to be a key factor driving functional decline, though real-time metabolic fluxes have never been assessed in DOX-cardiotoxicity. Hyperpolarized magnetic resonance imaging (MRI) can assess real-time metabolic fluxes in vivo. Here we show that cardiac functional decline in a clinically relevant rat-model of DOX-HF is preceded by a change in oxidative mitochondrial carbohydrate metabolism, measured by hyperpolarized MRI. The decreased metabolic fluxes were predominantly due to mitochondrial loss and additional mitochondrial dysfunction, and not, as widely assumed hitherto, to oxidative stress. Since hyperpolarized MRI has been successfully translated into clinical trials this opens up the potential to test cancer patients receiving DOX for early signs of cardiotoxicity.
AU  - Timm,KN
AU  - Perera,C
AU  - Ball,V
AU  - Henry,JA
AU  - Miller,JJ
AU  - Kerr,M
AU  - West,JA
AU  - Sharma,E
AU  - Broxholme,J
AU  - Logan,A
AU  - Savic,D
AU  - Dodd,MS
AU  - Griffin,JL
AU  - Murphy,MP
AU  - Heather,LC
AU  - Tyler,DJ
DO  - 10.1038/s42003-020-01440-z
PY  - 2020///
TI  - Early detection of doxorubicin-induced cardiotoxicity in rats by its cardiac metabolic signature assessed with hyperpolarized MRI.
T2  - Commun Biol
UR  - http://dx.doi.org/10.1038/s42003-020-01440-z
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33214680
VL  - 3
ER  -
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