Imperial College London
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ProfessorJulianGriffin

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 3220julian.griffin

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Whitehead:2021:10.1038/s41467-021-22272-3,
author = {Whitehead, A and Krause, FN and Moran, A and MacCannell, ADV and Scragg, JL and McNally, BD and Boateng, E and Murfitt, SA and Virtue, S and Wright, J and Garnham, J and Davies, GR and Dodgson, J and Schneider, JE and Murray, AJ and Church, C and Vidal-Puig, A and Witte, KK and Griffin, JL and Roberts, LD},
doi = {10.1038/s41467-021-22272-3},
journal = {Nat Commun},
title = {Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis.},
url = {http://dx.doi.org/10.1038/s41467-021-22272-3},
volume = {12},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid, 5-oxoproline, and β-hydroxyisobutyric acid as small molecule metabokines synthesized in browning adipocytes and secreted via monocarboxylate transporters. 3-methyl-2-oxovaleric acid, 5-oxoproline and β-hydroxyisobutyric acid induce a brown adipocyte-specific phenotype in white adipocytes and mitochondrial oxidative energy metabolism in skeletal myocytes both in vitro and in vivo. 3-methyl-2-oxovaleric acid and 5-oxoproline signal through cAMP-PKA-p38 MAPK and β-hydroxyisobutyric acid via mTOR. In humans, plasma and adipose tissue 3-methyl-2-oxovaleric acid, 5-oxoproline and β-hydroxyisobutyric acid concentrations correlate with markers of adipose browning and inversely associate with body mass index. These metabolites reduce adiposity, increase energy expenditure and improve glucose and insulin homeostasis in mouse models of obesity and diabetes. Our findings identify beige adipose-brown adipose-muscle physiological metabokine crosstalk.
AU  - Whitehead,A
AU  - Krause,FN
AU  - Moran,A
AU  - MacCannell,ADV
AU  - Scragg,JL
AU  - McNally,BD
AU  - Boateng,E
AU  - Murfitt,SA
AU  - Virtue,S
AU  - Wright,J
AU  - Garnham,J
AU  - Davies,GR
AU  - Dodgson,J
AU  - Schneider,JE
AU  - Murray,AJ
AU  - Church,C
AU  - Vidal-Puig,A
AU  - Witte,KK
AU  - Griffin,JL
AU  - Roberts,LD
DO  - 10.1038/s41467-021-22272-3
PY  - 2021///
TI  - Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis.
T2  - Nat Commun
UR  - http://dx.doi.org/10.1038/s41467-021-22272-3
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33772024
VL  - 12
ER  -
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