Imperial College London
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ProfessorJulianGriffin

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 3220julian.griffin

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Belcastro:2021:10.3390/nu13082768,
author = {Belcastro, L and Ferreira, CS and Saraiva, MA and Mucci, DB and Murgia, A and Lai, C and Vigor, C and Oger, C and Galano, J-M and Pinto, GDA and Griffin, JL and Torres, AG and Durand, T and Burton, GJ and Sardinha, FLC and El-Bacha, T},
doi = {10.3390/nu13082768},
journal = {Nutrients},
title = {Decreased Fatty Acid Transporter FABP1 and Increased Isoprostanes and Neuroprostanes in the Human Term Placenta: Implications for Inflammation and Birth Weight in Maternal Pre-Gestational Obesity.},
url = {http://dx.doi.org/10.3390/nu13082768},
volume = {13},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The rise in prevalence of obesity in women of reproductive age in developed and developing countries might propagate intergenerational cycles of detrimental effects on metabolic health. Placental lipid metabolism is disrupted by maternal obesity, which possibly affects the life-long health of the offspring. Here, we investigated placental lipid metabolism in women with pre-gestational obesity as a sole pregnancy complication and compared it to placental responses of lean women. Open profile and targeted lipidomics were used to assess placental lipids and oxidised products of docosahexaenoic (DHA) and arachidonic acid (AA), respectively, neuroprostanes and isoprostanes. Despite no overall signs of lipid accumulation, DHA and AA levels in placentas from obese women were, respectively, 2.2 and 2.5 times higher than those from lean women. Additionally, a 2-fold increase in DHA-derived neuroprostanes and a 1.7-fold increase in AA-derived isoprostanes were seen in the obese group. These changes correlated with a 70% decrease in placental FABP1 protein. Multivariate analyses suggested that neuroprostanes and isoprostanes are associated with maternal and placental inflammation and with birth weight. These results might shed light on the molecular mechanisms associated with altered placental fatty acid metabolism in maternal pre-gestational obesity, placing these oxidised fatty acids as novel mediators of placental function.
AU  - Belcastro,L
AU  - Ferreira,CS
AU  - Saraiva,MA
AU  - Mucci,DB
AU  - Murgia,A
AU  - Lai,C
AU  - Vigor,C
AU  - Oger,C
AU  - Galano,J-M
AU  - Pinto,GDA
AU  - Griffin,JL
AU  - Torres,AG
AU  - Durand,T
AU  - Burton,GJ
AU  - Sardinha,FLC
AU  - El-Bacha,T
DO  - 10.3390/nu13082768
PY  - 2021///
TI  - Decreased Fatty Acid Transporter FABP1 and Increased Isoprostanes and Neuroprostanes in the Human Term Placenta: Implications for Inflammation and Birth Weight in Maternal Pre-Gestational Obesity.
T2  - Nutrients
UR  - http://dx.doi.org/10.3390/nu13082768
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34444927
VL  - 13
ER  -
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