Imperial College London
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ProfessorJulianGriffin

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 3220julian.griffin

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Harshfield:2021:10.1186/s12916-021-02087-1,
author = {Harshfield, EL and Fauman, EB and Stacey, D and Paul, DS and Ziemek, D and Ong, RMY and Danesh, J and Butterworth, AS and Rasheed, A and Sattar, T and Zameer-Ul-Asar and Saleem, I and Hina, Z and Ishtiaq, U and Qamar, N and Mallick, NH and Yaqub, Z and Saghir, T and Rizvi, SNH and Memon, A and Ishaq, M and Rasheed, SZ and Memon, F-U-R and Jalal, A and Abbas, S and Frossard, P and Saleheen, D and Wood, AM and Griffin, JL and Koulman, A},
doi = {10.1186/s12916-021-02087-1},
journal = {BMC Med},
title = {Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci.},
url = {http://dx.doi.org/10.1186/s12916-021-02087-1},
volume = {19},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Genetic, lifestyle, and environmental factors can lead to perturbations in circulating lipid levels and increase the risk of cardiovascular and metabolic diseases. However, how changes in individual lipid species contribute to disease risk is often unclear. Moreover, little is known about the role of lipids on cardiovascular disease in Pakistan, a population historically underrepresented in cardiovascular studies. METHODS: We characterised the genetic architecture of the human blood lipidome in 5662 hospital controls from the Pakistan Risk of Myocardial Infarction Study (PROMIS) and 13,814 healthy British blood donors from the INTERVAL study. We applied a candidate causal gene prioritisation tool to link the genetic variants associated with each lipid to the most likely causal genes, and Gaussian Graphical Modelling network analysis to identify and illustrate relationships between lipids and genetic loci. RESULTS: We identified 253 genetic associations with 181 lipids measured using direct infusion high-resolution mass spectrometry in PROMIS, and 502 genetic associations with 244 lipids in INTERVAL. Our analyses revealed new biological insights at genetic loci associated with cardiometabolic diseases, including novel lipid associations at the LPL, MBOAT7, LIPC, APOE-C1-C2-C4, SGPP1, and SPTLC3 loci. CONCLUSIONS: Our findings, generated using a distinctive lipidomics platform in an understudied South Asian population, strengthen and expand the knowledge base of the genetic determinants of lipids and their association with cardiometabolic disease-related loci.
AU  - Harshfield,EL
AU  - Fauman,EB
AU  - Stacey,D
AU  - Paul,DS
AU  - Ziemek,D
AU  - Ong,RMY
AU  - Danesh,J
AU  - Butterworth,AS
AU  - Rasheed,A
AU  - Sattar,T
AU  - Zameer-Ul-Asar
AU  - Saleem,I
AU  - Hina,Z
AU  - Ishtiaq,U
AU  - Qamar,N
AU  - Mallick,NH
AU  - Yaqub,Z
AU  - Saghir,T
AU  - Rizvi,SNH
AU  - Memon,A
AU  - Ishaq,M
AU  - Rasheed,SZ
AU  - Memon,F-U-R
AU  - Jalal,A
AU  - Abbas,S
AU  - Frossard,P
AU  - Saleheen,D
AU  - Wood,AM
AU  - Griffin,JL
AU  - Koulman,A
DO  - 10.1186/s12916-021-02087-1
PY  - 2021///
TI  - Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci.
T2  - BMC Med
UR  - http://dx.doi.org/10.1186/s12916-021-02087-1
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34503513
VL  - 19
ER  -
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