Publications
285 results found
Fiedler T, Belova IV, Murch GE, et al., 2014, A comparative study of oxygen diffusion in tissue engineering scaffolds, JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, Vol: 25, Pages: 2573-2578, ISSN: 0957-4530
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- Citations: 23
Lusquinos F, del Val J, Arias-Gonzalez F, et al., 2014, Bioceramic 3D implants produced by laser assisted additive manufacturing, 8TH INTERNATIONAL CONFERENCE ON LASER ASSISTED NET SHAPE ENGINEERING (LANE 2014), Vol: 56, Pages: 309-316, ISSN: 1875-3892
, 2014, Additions and corrections for Journal of Materials Chemistry B published 11th November 2013 to 10th June 2014., J Mater Chem B, Vol: 2, Pages: 5478-5479
Wang D, Nakamura J, Poologasundarampillai G, et al., 2014, ToF-SIMS evaluation of calcium-containing silica/γ-PGA hybrid systems for bone regeneration., APPLIED SURFACE SCIENCE, Vol: 309, Pages: 231-239, ISSN: 0169-4332
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- Citations: 7
Poologasundarampillai G, Yu B, Tsigkou O, et al., 2014, Poly(gamma-glutamic acid)/Silica Hybrids with Calcium Incorporated in the Silica Network by Use of a Calcium Alkoxide Precursor, Chemistry-A European Journal, Vol: 20, Pages: 8149-8160, ISSN: 1521-3765
Current materials used for bone regeneration are usually bioactive ceramics or glasses. Although they bond to bone, they are brittle. There is a need for new materials that can combine bioactivity with toughness and controlled biodegradation. Sol-gel hybrids have the potential to do this through their nanoscale interpenetrating networks (IPN) of inorganic and organic components. Poly(γ-glutamic acid) (γ-PGA) was introduced into the sol-gel process to produce a hybrid of γ-PGA and bioactive silica. Calcium is an important element for bone regeneration but calcium sources that are used traditionally in the sol-gel process, such as Ca salts, do not allow Ca incorporation into the silicate network during low-temperature processing. The hypothesis for this study was that using calcium methoxyethoxide (CME) as the Ca source would allow Ca incorporation into the silicate component of the hybrid at room temperature. The produced hybrids would have improved mechanical properties and controlled degradation compared with hybrids of calcium chloride (CaCl2), in which the Ca is not incorporated into the silicate network. Class II hybrids, with covalent bonds between the inorganic and organic species, were synthesised by using organosilane. Calcium incorporation in both the organic and inorganic IPNs of the hybrid was improved when CME was used. This was clearly observed by using FTIR and solid-state NMR spectroscopy, which showed ionic cross-linking of γ-PGA by Ca and a lower degree of condensation of the Si species compared with the hybrids made with CaCl2 as the Ca source. The ionic cross-linking of γ-PGA by Ca resulted in excellent compressive strength and reduced elastic modulus as measured by compressive testing and nanoindentation, respectively. All hybrids showed bioactivity as hydroxyapatite (HA) was formed after immersion in simulated body fluid (SBF).
Poologasundarampillai G, Wang D, Li S, et al., 2014, Cotton-wool-like bioactive glasses for bone regeneration, Acta Biomaterialia, Vol: 10, Pages: 3733-3746, ISSN: 1742-7061
Inorganic sol–gel solutions were electrospun to produce the first bioactive three-dimensional (3-D) scaffolds for bone tissue regeneration with a structure like cotton-wool (or cotton candy). This flexible 3-D fibrous structure is ideal for packing into complex defects. It also has large inter-fiber spaces to promote vascularization, penetration of cells and transport of nutrients throughout the scaffold. The 3-D fibrous structure was obtained by electrospinning, where the applied electric field and the instabilities exert tremendous force on the spinning jet, which is required to be viscoelastic to prevent jet break up. Previously, polymer binding agents were used with inorganic solutions to produce electrospun composite two-dimensional fibermats, requiring calcination to remove the polymer. This study presents novel reaction and processing conditions for producing a viscoelastic inorganic sol–gel solution that results in fibers by the entanglement of the intermolecularly overlapped nanosilica species in the solution, eliminating the need for a binder. Three-dimensional cotton-wool-like structures were only produced when solutions containing calcium nitrate were used, suggesting that the charge of the Ca2+ ions had a significant effect. The resulting bioactive silica fibers had a narrow diameter range of 0.5–2 μm and were nanoporous. A hydroxycarbonate apatite layer was formed on the fibers within the first 12 h of soaking in simulated body fluid. MC3T3-E1 preosteoblast cells cultured on the fibers showed no adverse cytotoxic effect and they were observed to attach to and spread in the material.
Connell LS, Romer F, Suárez Menéndez M, et al., 2014, Chemical characterisation and fabrication of Chitosan-Silica hybrid scaffolds with 3-glycidoxypropyl trimethoxysilane, Journal of Materials Chemistry B
Wang D, Poologasundarampillai G, van den Bergh W, et al., 2014, Strategies for the chemical analysis of highly porous bone scaffolds using secondary ion mass spectrometry, BIOMEDICAL MATERIALS, Vol: 9, ISSN: 1748-6041
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- Citations: 11
Mahony O, Yue S, Turdean-Ionescu C, et al., 2014, Silica-gelatin hybrids for tissue regeneration: inter-relationships between the process variables, JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY, Vol: 69, Pages: 288-298, ISSN: 0928-0707
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- Citations: 52
Ahmad NE, Jones JR, Lee WE, 2014, Durability studies of simulated UK high level waste glass, Pages: 291-296, ISSN: 0272-9172
A simulated Magnox glass which is Mg- and Al- rich was subjected to aqueous corrosion in static mode with deionised water at 90 °C for 7-28 days and assessed using X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM) with Energy X-Ray Dispersive Spectroscopy (EDS) and Inductively Coupled Plasma - Optical Emission Spectroscopy (ICP-OES). XRD revealed both amorphous phase and crystals in the glass structure. The crystals were Ni and Cr rich spinels and ruthenium oxide. After two weeks of incubation in deionised water, the glass surface was covered by a ∼ 11 μm thick Si-rich layer whilst mobile elements and transition metals like Na, B, and Fe were strongly depleted. The likely corrosion mechanism and in particular the role of Mg and Al in the glass structure are discussed. Keywords: high level waste glass, durability, corrosion mechanism.
Tsigkou O, Labbaf S, Stevens MM, et al., 2014, Monodispersed Bioactive Glass Submicron Particles and Their Effect on Bone Marrow and Adipose Tissue-Derived Stem Cells, ADVANCED HEALTHCARE MATERIALS, Vol: 3, Pages: 115-125, ISSN: 2192-2640
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- Citations: 98
Obata A, Ito S, Iwanaga N, et al., 2014, Poly(γ-glutamic acid)-silica hybrids with fibrous structure: effect of cation and silica concentration on molecular structure, degradation rate and tensile properties, RSC ADVANCES, Vol: 4, Pages: 52491-52499, ISSN: 2046-2069
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- Citations: 13
Connell LS, Romer F, Suarez M, et al., 2014, Chemical characterisation and fabrication of chitosan-silica hybrid scaffolds with 3-glycidoxypropyl trimethoxysilane (vol 2, pg 668, 2014), JOURNAL OF MATERIALS CHEMISTRY B, Vol: 2, Pages: 5479-5479, ISSN: 2050-750X
Gabrielli L, Connell LS, Russo L, et al., 2013, Exploring GPTMS reactivity against simple nucleophiles: chemistry beyond hybrid materials fabrication, RSC Advances, Vol: 4, Pages: 1841-1848
Midha S, Kim TB, van den Bergh W, et al., 2013, Preconditioned 70S30C bioactive glass foams promote osteogenesis in vivo, ACTA BIOMATERIALIA, Vol: 9, Pages: 9169-9182, ISSN: 1742-7061
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- Citations: 97
Zhang Z, Jones D, Yue S, et al., 2013, Hierarchical tailoring of strut architecture to control permeability of additive manufactured titanium implants, MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, Vol: 33, Pages: 4055-4062, ISSN: 0928-4931
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- Citations: 72
Valliant EM, Romer F, Wang D, et al., 2013, Bioactivity in silica/poly(γ-glutamic acid) sol-gel hybrids through calcium chelation, ACTA BIOMATERIALIA, Vol: 9, Pages: 7662-7671, ISSN: 1742-7061
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- Citations: 49
Obata A, Ozasa H, Kasuga T, et al., 2013, Cotton wool-like poly(lactic acid)/vaterite composite scaffolds releasing soluble silica for bone tissue engineering, JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, Vol: 24, Pages: 1649-1658, ISSN: 0957-4530
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- Citations: 22
Russo L, Gabrielli L, Valliant EM, et al., 2013, Novel silica/bis(3-aminopropyl) polyethylene glycol inorganic/organic hybrids by sol-gel chemistry, MATERIALS CHEMISTRY AND PHYSICS, Vol: 140, Pages: 168-175, ISSN: 0254-0584
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- Citations: 18
Gabrielli L, Russo L, Poveda A, et al., 2013, Epoxide Opening versus Silica Condensation during Sol-Gel Hybrid Biomaterial Synthesis, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 19, Pages: 7856-7864, ISSN: 0947-6539
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- Citations: 61
Midha S, van den Bergh W, Kim TB, et al., 2013, Bioactive Glass Foam Scaffolds are Remodelled by Osteoclasts and Support the Formation of Mineralized Matrix and Vascular Networks In Vitro, ADVANCED HEALTHCARE MATERIALS, Vol: 2, Pages: 490-499, ISSN: 2192-2640
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- Citations: 49
Jones JR, 2013, Porous bioactive ceramic and glass scaffolds for bone regeneration, An Introduction to Bioceramics, Second Edition, Pages: 463-485, ISBN: 9781908977151
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- Citations: 4
Jones JR, 2013, Review of bioactive glass: From Hench to hybrids, ACTA BIOMATERIALIA, Vol: 9, Pages: 4457-4486, ISSN: 1742-7061
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- Citations: 1559
Nakamura J, Poologasundarampillai G, Jones JR, et al., 2013, Tracking the formation of vaterite particles containing aminopropyl-functionalized silsesquioxane and their structure for bone regenerative medicine, JOURNAL OF MATERIALS CHEMISTRY B, Vol: 1, Pages: 4446-4454, ISSN: 2050-750X
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- Citations: 35
Yu B, Turdean-Ionescu CA, Martin RA, et al., 2012, Effect of Calcium Source on Structure and Properties of Sol-Gel Derived Bioactive Glasses, LANGMUIR, Vol: 28, Pages: 17465-17476, ISSN: 0743-7463
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- Citations: 71
Obata A, Hasegawa D, Nakamura J, et al., 2012, Induction of hydroxycarbonate apatite formation on polyethylene or alumina substrates by spherical vaterite particles deposition, MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, Vol: 32, Pages: 1976-1981, ISSN: 0928-4931
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- Citations: 2
Jones J, Clare A, 2012, Bio-Glasses: An Introduction, Publisher: Wiley, ISBN: 9780470711613
This new work is dedicated to glasses and their variants which can be used as biomaterials to repair diseased and damaged tissues. Bio–glasses are superior to other biomaterials in many applications, such as healing bone by signaling stem cells to become bone cells. Key features: First book on biomaterials to focus on bio–glasses Edited by a leading authority on bio–glasses trained by one of its inventors, Dr Larry Hench Supported by the International Commission on Glass (ICG) Authored by members of the ICG Biomedical Glass Committee, with the goal of creating a seamless textbook Written in an accessible style to facilitate rapid absorption of information Covers all types of glasses, their properties and applications, and demonstrates how glass is an attractive improvement to current procedures Of interest to the biomedical as well as the materials science community. The book covers all types of glasses: traditional glasses, bioactive glasses, sol–gel glasses, phosphate glasses, glass–ceramics, composites and hybrids. Alongside discussion on how bio–glasses are made, their properties, and the reasons for their use, the authors also cover their applications in dentistry, bone regeneration and tissue engineering and cancer treatment. Its solid guidance describes the steps needed to take a new material from concept to clinic, covering the essentials of patenting, scale–up, quality assurance and FDA approval.
Jones JR, 2012, Sol-Gel Derived Glasses for Medicine, Bio-Glasses: An Introduction, Pages: 29-44, ISBN: 9780470711613
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- Citations: 16
Boccaccini AR, Jones JR, Chen QZ, 2012, Composites Containing Bioactive Glass, Bio-Glasses: An Introduction, Pages: 121-138, ISBN: 9780470711613
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- Citations: 9
Jones JR, 2012, Bioactive Glass as Synthetic Bone Grafts and Scaffolds for Tissue Engineering, Bio-Glasses: An Introduction, Pages: 177-201, ISBN: 9780470711613
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- Citations: 3
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