Imperial College London
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ProfessorJulianJones

Faculty of Engineering, Department of Materials

Professor of Biomaterials
 
 
 
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Contact

 

+44 (0)20 7594 6749julian.r.jones

 
 
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Location

 

207GoldsmithSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Barrioni:2019:10.1007/s10856-019-6288-9,
author = {Barrioni, BR and Norris, E and Li, S and Naruphontjirakul, P and Jones, JR and Pereira, MDM},
doi = {10.1007/s10856-019-6288-9},
journal = {Journal of Materials Science: Materials in Medicine},
title = {Osteogenic potential of sol-gel bioactive glasses containing manganese},
url = {http://dx.doi.org/10.1007/s10856-019-6288-9},
volume = {30},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Bioactive glasses (BGs) are widely used for bone regeneration, and allow the incorporation of different ions with therapeutic properties into the glass network. Amongst the different ions with therapeutic benefits, manganese (Mn) has been shown to influence bone metabolism and activate human osteoblasts integrins, improving cell adhesion, proliferation and spreading. Mn has also been incorporated into bioceramics as a therapeutic ion for improved osteogenesis. Here, up to 4.4 mol% MnO was substituted for CaO in the 58S composition (60 mol% SiO2, 36 mol% CaO, 4 mol% P2O5) and its effects on the glass properties and capability to influence the osteogenic differentiation were evaluated. Mn-containing BGs with amorphous structure, high specific surface area and nanoporosity were obtained. The presence of Mn2+ species was confirmed by X-ray photoelectron spectroscopy (XPS). Mn-containing BGs presented no cytotoxic effect on human mesenchymal stem cells (hMSCs) and enabled sustained ion release in culture medium. hMSCs osteogenic differentiation stimulation and influence on the mineralisation process was also confirmed through the alkaline phosphatase (ALP) activity, and expression of osteogenic differentiation markers, such as collagen type I, osteopontin and osteocalcin, which presented higher expression in the presence of Mn-containing samples compared to control. Results show that the release of manganese ions from bioactive glass provoked human mesenchymal stem cell (hMSC) differentiation down a bone pathway, whereas hMSCs exposed to the Mn-free glass did not differentiate. Mn incorporation offers great promise for obtaining glasses with superior properties for bone tissue regeneration.
AU  - Barrioni,BR
AU  - Norris,E
AU  - Li,S
AU  - Naruphontjirakul,P
AU  - Jones,JR
AU  - Pereira,MDM
DO  - 10.1007/s10856-019-6288-9
PY  - 2019///
SN  - 0957-4530
TI  - Osteogenic potential of sol-gel bioactive glasses containing manganese
T2  - Journal of Materials Science: Materials in Medicine
UR  - http://dx.doi.org/10.1007/s10856-019-6288-9
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000475588800002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/72304
VL  - 30
ER  -
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